The oxylipin analog CS585 prevents platelet activation and thrombosis through activation of the prostacyclin receptor

Heart Disease and Stroke Statistics—2023 Update: A Report From the American Heart Association

(2023) Connie W. Tsao et al.   CIRCULATION

Novel Strategy to Combat the Procoagulant Phenotype in Heparin-Induced Thrombocytopenia Using 12-LOX Inhibition

(2023) Stephanie A. Renna et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Upregulation of cAMP prevents antibody-mediated thrombus formation in COVID-19

(2022) Jan Zlamal et al.   Blood Advances

Diagnosis and Treatment of Pulmonary Arterial Hypertension

(2022) Nicole F. Ruopp et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The Antifibrotic Effects of Inhaled Treprostinil: An Emerging Option for ILD

(2022) Martin Kolb et al.   ADVANCES IN THERAPY

Dual Antiplatelet Therapy Is Associated with Increased Risk of Bleeding and Decreased Risk of Stroke Following Carotid Endarterectomy

(2022) Rohini J. Patel et al.   ANNALS OF VASCULAR SURGERY

A review of non-prostanoid, eicosanoid receptors: expression, characterization, regulation, and mechanism of action

(2021) Roger G. Biringer   Journal of Cell Communication and Signaling

Platelet ACKR3/CXCR7 Favors Anti-Platelet Lipids over an Atherothrombotic Lipidome and Regulates Thrombo-inflammation

(2021) Malgorzata Cebo et al.   BLOOD

Therapeutic strategies for thrombosis: new targets and approaches

(2020) Nigel Mackman et al.   NATURE REVIEWS DRUG DISCOVERY

Prostacyclin facilitates vascular smooth muscle cell phenotypic transformation via activating TP receptors when IP receptors are deficient

(2020) Ziqing Li et al.   Acta Physiologica

International Union of Basic and Clinical Pharmacology. CIX. Differences and Similarities between Human and Rodent Prostaglandin E2 Receptors (EP1–4) and Prostacyclin Receptor (IP): Specific Roles in Pathophysiologic Conditions

(2020) Xavier Norel et al.   PHARMACOLOGICAL REVIEWS

A Review of Prostanoid Receptors: Expression, Characterization, Regulation, and Mechanism of Action

(2020) Roger G. Biringer   Journal of Cell Communication and Signaling

Omega-6 DPA and its 12-lipoxygenase–oxidized lipids regulate platelet reactivity in a nongenomic PPARα-dependent manner

(2020) Jennifer Yeung et al.   Blood Advances

DHA 12‐LOX‐derived oxylipins regulate platelet activation and thrombus formation through a PKA‐dependent signaling pathway

(2020) Adriana Yamaguchi et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Synthetic high-density lipoproteins loaded with an antiplatelet drug for efficient inhibition of thrombosis in mice

(2020) Hongliang He et al.   Science Advances

Utility of thromboelastography for the diagnosis of von Willebrand disease

(2019) Katherine Regling et al.   PEDIATRIC BLOOD & CANCER

Selective Prostacyclin Receptor Agonist Selexipag, in Contrast to Prostacyclin Analogs, Does Not Evoke Paradoxical Vasoconstriction of the Rat Femoral Artery

(2018) Keith Morrison et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Platelet Signaling and Disease: Targeted Therapy for Thrombosis and Other Related Diseases

(2018) Jennifer Yeung et al.   PHARMACOLOGICAL REVIEWS

Blood clot parameters: Thromboelastography and scanning electron microscopy in research and clinical practice

(2017) Etheresia Pretorius et al.   THROMBOSIS RESEARCH

12(S)-HETrE, a 12-Lipoxygenase Oxylipin of Dihomo-γ-Linolenic Acid, Inhibits Thrombosis via GαsSignaling in PlateletsHighlights

(2016) Jennifer Yeung et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Assessment of platelet-derived thrombogenicity with the total thrombus-formation analysis system in coronary artery disease patients receiving antiplatelet therapy

(2016) Y. Arima et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Vorapaxar and diplopia: Possible off-target PAR-receptor mismodulation

(2016) V. L. Serebruany et al.   THROMBOSIS AND HAEMOSTASIS

Mechanism of Race-Dependent Platelet Activation Through the Protease-Activated Receptor-4 and Gq Signaling Axis

(2014) Benjamin E. Tourdot et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Off-target effects of glycoprotein IIb/IIIa receptor inhibitors

(2014) Małgorzata Ostrowska et al.   Cardiology Journal

Plasma fibronectin supports hemostasis and regulates thrombosis

(2014) Yiming Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Prostacyclin Receptor Regulation --- from Transcription to Trafficking

(2012) C. Midgett et al.   CURRENT MOLECULAR MEDICINE

Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo

(2012) Marie-Luise von Brühl et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Investigations of human platelet-type 12-lipoxygenase: role of lipoxygenase products in platelet activation

(2012) Kenneth N. Ikei et al.   JOURNAL OF LIPID RESEARCH

A novel automated microchip flow-chamber system to quantitatively evaluate thrombus formation and antithrombotic agents under blood flow conditions

(2011) K. HOSOKAWA et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS