Discovery of a novel GPR35 agonist with high and equipotent species potency for oral treatment of IBD

Aminosalicylates target GPR35, partly contributing to the prevention of DSS-induced colitis

(2023) Wuxiyar Otkur et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

GPR35: from enigma to therapeutic target

(2023) Graeme Milligan   TRENDS IN PHARMACOLOGICAL SCIENCES

Disruption of GPR35 Exacerbates Dextran Sulfate Sodium-Induced Colitis in Mice

(2018) Shukkur M. Farooq et al.   DIGESTIVE DISEASES AND SCIENCES

Ulcerative colitis

(2017) Ryan Ungaro et al.   LANCET

G protein-coupled receptor 35 contributes to mucosal repair in mice via migration of colonic epithelial cells

(2017) Takuya Tsukahara et al.   PHARMACOLOGICAL RESEARCH

Treatment of inflammatory bowel disease (IBD)

(2014) Anand B. Pithadia et al.   Pharmacological Reports

Review of the disease course among adult ulcerative colitis population-based longitudinal cohorts

(2011) Fernando Magro et al.   INFLAMMATORY BOWEL DISEASES

Identification of novel species-selective agonists of the G-protein-coupled receptor GPR35 that promote recruitment of β-arrestin-2 and activate Gα13

(2010) Laura Jenkins et al.   BIOCHEMICAL JOURNAL

Targeting of the Orphan Receptor GPR35 by Pamoic Acid: A Potent Activator of Extracellular Signal-Regulated Kinase and  -Arrestin2 with Antinociceptive Activity

(2010) P. Zhao et al.   MOLECULAR PHARMACOLOGY

Common variants at five new loci associated with early-onset inflammatory bowel disease

(2009) Marcin Imielinski et al.   NATURE GENETICS