Cathepsin L-mediated EGFR cleavage affects intracellular signalling pathways in cancer

Cysteine cathepsins: A long and winding road towards clinics

(2022) Monika Biasizzo et al.   MOLECULAR ASPECTS OF MEDICINE

Review on Epidermal Growth Factor Receptor (EGFR) Structure, Signaling Pathways, Interactions, and Recent Updates of EGFR Inhibitors

(2020) Dima A. Sabbah et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Cysteine Cathepsins and their Extracellular Roles: Shaping the Microenvironment

(2019) Eva Vidak et al.   Cells

Oncogenic mutations at the EGFR ectodomain structurally converge to remove a steric hindrance on a kinase-coupled cryptic epitope

(2019) Laura Orellana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Degradomics in Biomarker Discovery

(2019) Marija Grozdanić et al.   Proteomics Clinical Applications

The NAE Pathway: Autobahn to the Nucleus for Cell Surface Receptors

(2019) Shah et al.   Cells

Cetuximab for treating non-small cell lung cancer

(2018) Luca Mazzarella et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Cysteine cathepsins in extracellular matrix remodeling: Extracellular matrix degradation and beyond

(2018) Matej Vizovišek et al.   MATRIX BIOLOGY

Epidermal growth factor receptor: Structure-function informing the design of anticancer therapeutics

(2018) Ruth A. Mitchell et al.   EXPERIMENTAL CELL RESEARCH

Molecular-Targeted Therapies for Epidermal Growth Factor Receptor and Its Resistance Mechanisms

(2017) Toshimitsu Yamaoka et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

STAT3 signaling mediates tumour resistance to EGFR targeted therapeutics

(2017) Ahmad A. Zulkifli et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The Future of Cysteine Cathepsins in Disease Management

(2017) Lovro Kramer et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Clustered localization of EGFRvIII in glioblastoma cells as detected by high precision localization microscopy

(2016) Philip S. Boyd et al.   Nanoscale

Cathepsin S attenuates endosomal EGFR signalling: A mechanical rationale for the combination of cathepsin S and EGFR tyrosine kinase inhibitors

(2016) Chien-Chang Huang et al.   Scientific Reports

Ligand-Independent EGFR Signaling

(2015) G. Guo et al.   CANCER RESEARCH

Proteomic Identification of Cysteine Cathepsin Substrates Shed from the Surface of Cancer Cells

(2015) Barbara Sobotič et al.   MOLECULAR & CELLULAR PROTEOMICS

Cysteine cathepsins and their potential in clinical therapy and biomarker discovery

(2014) Marko Fonović et al.   Proteomics Clinical Applications

The EGFR Family: Not So Prototypical Receptor Tyrosine Kinases

(2014) M. A. Lemmon et al.   Cold Spring Harbor Perspectives in Biology

Constitutive and ligand-induced EGFR signalling triggers distinct and mutually exclusive downstream signalling networks

(2014) Sharmistha Chakraborty et al.   Nature Communications

The epidermal growth factor receptor variant III (EGFRvIII): where wild things are altered

(2013) Hui K. Gan et al.   FEBS Journal

The ErbB/HER family of protein-tyrosine kinases and cancer

(2013) Robert Roskoski   PHARMACOLOGICAL RESEARCH

Nuclear EGFR as a molecular target in cancer

(2013) Toni M. Brand et al.   RADIOTHERAPY AND ONCOLOGY

Nuclear Translocation of Epidermal Growth Factor Receptor by Akt-dependent Phosphorylation Enhances Breast Cancer-resistant Protein Expression in Gefitinib-resistant Cells

(2011) Wei-Chien Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selecting protein N-terminal peptides by combined fractional diagonal chromatography

(2011) An Staes et al.   Nature Protocols

Proteolytic networks in cancer

(2011) Steven D. Mason et al.   TRENDS IN CELL BIOLOGY

Cetuximab induces mitochondrial translocalization of EGFRvIII, but not EGFR: involvement of mitochondria in tumor drug resistance?

(2011) Agnieszka Dreier et al.   TUMOR BIOLOGY

Synergistic antitumor effects of combined cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in mice

(2010) L. Sevenich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear EGFR contributes to acquired resistance to cetuximab

(2009) C Li et al.   ONCOGENE

Oncogenic EGFR Signaling Networks in Glioma

(2009) P. H. Huang et al.   Science Signaling

Survival of Cancer Cells Is Maintained by EGFR Independent of Its Kinase Activity

(2008) Zhang Weihua et al.   CANCER CELL

The epidermal growth factor receptor family: Biology driving targeted therapeutics

(2008) M. J. Wieduwilt et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Inhibitory Fragment from the p41 Form of Invariant Chain Can Regulate Activity of Cysteine Cathepsins in Antigen Presentation

(2008) Marko Mihelič et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The epidermal growth factor receptor (EGFR) is proteolytically modified by the Matriptase–Prostasin serine protease cascade in cultured epithelial cells

(2007) Mengqian Chen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH