SMURF1 controls the PPP3/calcineurin complex and TFEB at a regulatory node for lysosomal biogenesis

The exploitation of host autophagy and ubiquitin machinery by Mycobacterium tuberculosis in shaping immune responses and host defense during infection

(2022) Mohd Shariq et al.   Autophagy

E3 ligase Smurf1 protects against misfolded SOD1 in neuronal cells by promoting its K63 ubiquitylation and aggresome formation

(2022) Lei Dong et al.   HUMAN MOLECULAR GENETICS

Autophagy in cancer cell remodeling and quality control

(2022) Grace A. Hernandez et al.   MOLECULAR CELL

Trehalose causes low-grade lysosomal stress to activate TFEB and the autophagy-lysosome biogenesis response

(2021) Se-Jin Jeong et al.   Autophagy

A NOVEL NOX/PHOX-CD38-NAADP-TFEB AXIS IMPORTANT FOR MACROPHAGE ACTIVATION DURING BACTERIAL PHAGOCYTOSIS

(2021) Mehran Najibi et al.   Autophagy

Full-coverage regulations of autophagy by ROS: from induction to maturation

(2021) Jing Zhou et al.   Autophagy

GABARAP sequesters the FLCN-FNIP tumor suppressor complex to couple autophagy with lysosomal biogenesis

(2021) Jonathan M. Goodwin et al.   Science Advances

Smurf1 silencing restores PTEN expression that ameliorates progression of human glioblastoma and sensitizes tumor cells to mTORC1/C2 inhibitor Torin1

(2021) Qin Xia et al.   iScience

mTOR at the nexus of nutrition, growth, ageing and disease

(2020) Grace Y. Liu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A substrate-specific mTORC1 pathway underlies Birt–Hogg–Dubé syndrome

(2020) Gennaro Napolitano et al.   NATURE

Oncogenic Smurf1 promotes PTEN wild-type glioblastoma growth by mediating PTEN ubiquitylation

(2020) Qin Xia et al.   ONCOGENE

LC3 lipidation is essential for TFEB activation during the lysosomal damage response to kidney injury

(2020) Shuhei Nakamura et al.   NATURE CELL BIOLOGY

ESRRA (estrogen related receptor alpha) is a critical regulator of intestinal homeostasis through activation of autophagic flux via gut microbiota

(2020) Sup Kim et al.   Autophagy

USP16-mediated deubiquitination of calcineurin A controls peripheral T cell maintenance

(2019) Yu Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Galectin-3 Coordinates a Cellular System for Lysosomal Repair and Removal

(2019) Jingyue Jia et al.   DEVELOPMENTAL CELL

Galectins Control mTOR in Response to Endomembrane Damage

(2018) Jingyue Jia et al.   MOLECULAR CELL

Cargo recognition and degradation by selective autophagy

(2018) Damián Gatica et al.   NATURE CELL BIOLOGY

TFEB and TFE3: Linking Lysosomes to Cellular Adaptation to Stress

(2016) Nina Raben et al.   Annual Review of Cell and Developmental Biology

Lysosome calcium in ROS regulation of autophagy

(2016) Xiaoli Zhang et al.   Autophagy

TRIMs and Galectins Globally Cooperate and TRIM16 and Galectin-3 Co-direct Autophagy in Endomembrane Damage Homeostasis

(2016) Santosh Chauhan et al.   DEVELOPMENTAL CELL

Control of NFAT Isoform Activation and NFAT-Dependent Gene Expression through Two Coincident and Spatially Segregated Intracellular Ca 2+ Signals

(2016) Pulak Kar et al.   MOLECULAR CELL

Lysosomal calcium regulates autophagy

(2015) Diego L Medina et al.   Autophagy

Transcriptional control of autophagy–lysosome function drives pancreatic cancer metabolism

(2015) Rushika M. Perera et al.   NATURE

Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB

(2015) Diego L. Medina et al.   NATURE CELL BIOLOGY

Chaperone-mediated autophagy regulates T cell responses through targeted degradation of negative regulators of T cell activation

(2014) Rut Valdor et al.   NATURE IMMUNOLOGY

The LxVP and PxIxIT NFAT Motifs Bind Jointly to Overlapping Epitopes on Calcineurin’s Catalytic Domain Distant to the Regulatory Domain

(2014) Maayan Gal et al.   STRUCTURE

MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB

(2012) Jose A. Martina et al.   Autophagy

Extracellular M. tuberculosis DNA Targets Bacteria for Autophagy by Activating the Host DNA-Sensing Pathway

(2012) Robert O. Watson et al.   CELL

Galectin 8 targets damaged vesicles for autophagy to defend cells against bacterial invasion

(2012) Teresa L. M. Thurston et al.   NATURE

The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis

(2012) A. Roczniak-Ferguson et al.   Science Signaling

Image-based genome-wide siRNA screen identifies selective autophagy factors

(2011) Anthony Orvedahl et al.   NATURE

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

(2011) R. Zoncu et al.   SCIENCE

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

The Proline-Rich N-Terminal Sequence of Calcineurin Aβ Determines Substrate Binding

(2009) Susann Kilka et al.   BIOCHEMISTRY

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE