USP16-mediated deubiquitination of calcineurin A controls peripheral T cell maintenance

Calcineurin-mediated IL-2 production by CD11chighMHCII+ myeloid cells is crucial for intestinal immune homeostasis

(2018) Andrea Mencarelli et al.   Nature Communications

Unique properties of TCR-activated p38 are necessary for NFAT-dependent T-cell activation

(2018) Muhammad S. Alam et al.   PLOS BIOLOGY

Store-Operated Ca 2+ Entry Controls Clonal Expansion of T Cells through Metabolic Reprogramming

(2017) Martin Vaeth et al.   IMMUNITY

Calcium-mediated shaping of naive CD4 T-cell phenotype and function

(2017) Vincent Guichard et al.   eLife

The Calcineurin-FoxO-MuRF1 signaling pathway regulates myofibril integrity in cardiomyocytes

(2017) Hirohito Shimizu et al.   eLife

Cooperative autoinhibition and multi-level activation mechanisms of calcineurin

(2016) Sheng-Jie Li et al.   CELL RESEARCH

Recruitment of calcineurin to the TCR positively regulates T cell activation

(2016) Debjani Dutta et al.   NATURE IMMUNOLOGY

Calcium at the Center of Cell Signaling: Interplay between Endoplasmic Reticulum, Mitochondria, and Lysosomes

(2016) Anna Raffaello et al.   TRENDS IN BIOCHEMICAL SCIENCES

USP16 Downregulation by Carboxyl-terminal Truncated HBx Promotes the Growth of Hepatocellular Carcinoma Cells

(2016) Yu Qian et al.   Scientific Reports

The Transcription Factor NFAT Promotes Exhaustion of Activated CD8 + T Cells

(2015) Gustavo J. Martinez et al.   IMMUNITY

Usp16 regulates kinetochore localization of Plk1 to promote proper chromosome alignment in mitosis

(2015) Xiaolong Zhuo et al.   JOURNAL OF CELL BIOLOGY

The histone H2A deubiquitinase Usp16 regulates hematopoiesis and hematopoietic stem cell function

(2015) Yue Gu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Carvedilol reverses cardiac insufficiency in AKAP5 knockout mice by normalizing the activities of calcineurin and CaMKII

(2014) X. Li et al.   CARDIOVASCULAR RESEARCH

Muscle-Specific RING Finger 1 Negatively Regulates Pathological Cardiac Hypertrophy Through Downregulation of Calcineurin A

(2014) Yasuhiro Maejima et al.   Circulation-Heart Failure

Chaperone-mediated autophagy regulates T cell responses through targeted degradation of negative regulators of T cell activation

(2014) Rut Valdor et al.   NATURE IMMUNOLOGY

The endoplasmic reticulum and junctional membrane communication during calcium signaling

(2013) Andy K.M. Lam et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Acute lymphoblastic leukemia in children with Down syndrome: a retrospective analysis from the Ponte di Legno study group

(2013) T. D. Buitenkamp et al.   BLOOD

The Aurora B Kinase and the Polycomb Protein Ring1B Combine to Regulate Active Promoters in Quiescent Lymphocytes

(2013) Alberto Frangini et al.   MOLECULAR CELL

Usp16 contributes to somatic stem-cell defects in Down’s syndrome

(2013) Maddalena Adorno et al.   NATURE

The Molecular Mechanism of Substrate Engagement and Immunosuppressant Inhibition of Calcineurin

(2013) Simina Grigoriu et al.   PLOS BIOLOGY

TRAF3 negatively regulates calcineurin-NFAT pathway by targeting calcineurin B subunit for degradation

(2012) Xinyu Wang et al.   IUBMB LIFE

Calcium Signaling

(2012) M. D. Bootman   Cold Spring Harbor Perspectives in Biology

Endoplasmic-Reticulum Calcium Depletion and Disease

(2011) D. Mekahli et al.   Cold Spring Harbor Perspectives in Biology

L-type Ca2+ channels: A new player in the regulation of Ca2+ signaling, cell activation and cell survival in immune cells

(2009) Yoshihiro Suzuki et al.   MOLECULAR IMMUNOLOGY

NFAT isoforms control activity-dependent muscle fiber type specification

(2009) E. Calabria et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD4 T-cell differentiation and inflammatory bowel disease

(2009) Lauren A. Zenewicz et al.   TRENDS IN MOLECULAR MEDICINE

NFAT Binding and Regulation of T Cell Activation by the Cytoplasmic Scaffolding Homer Proteins

(2008) G. N. Huang et al.   SCIENCE

NFAT signaling in neural development and axon growth

(2007) Tuan Nguyen et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE