Article
Chemistry, Physical
Olatunji Ajiteru, Ok Joo Lee, Jung-Ho Kim, Young Jin Lee, Ji Seung Lee, Hanna Lee, Md. Tipu Sultan, Chan Hum Park
Summary: Wound dressings play a critical role in wound healing. Hydrocolloid wound dressings have been developed as effective solutions for wound fluid control, adhering to the wound site, and preventing infection. This study aimed to enhance wound healing and improve the mechanical characteristics of hydrocolloid dressings by fabricating Mirderm, a hydrocolloid dressing infused with myrrh resin. The study found that Mirderm demonstrated superior wound healing and mechanical capabilities compared to commercially available hydrocolloid dressings and medical gauze, suggesting it may be an improvement over standard dressings.
COLLOID AND INTERFACE SCIENCE COMMUNICATIONS
(2022)
Article
Engineering, Environmental
Shuang Liu, Yingsong Zhao, Ming Li, Lei Nie, Qianqian Wei, Oseweuba Valentine Okoro, Hafez Jafari, Siyuan Wang, Jun Deng, Jianghai Chen, Amin Shavandi, Lihong Fan
Summary: Bioactive composite hydrogels were created using decellularized extracellular matrix (ECM), GelMA, and Polydopamine-loaded Asiaticoside (AC@PDA) nanoparticles as wound dressings. The hydrogels showed good mechanical properties and moisture retention, and the addition of nanoparticles improved their elasticity and shape recovery. In vitro and in vivo testing demonstrated their biocompatibility and ability to promote wound healing, with the AC@PDA/ECM-G hydrogel showing the best performance in terms of wound closure and hair follicle formation.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Biotechnology & Applied Microbiology
Victor Alfonso Solarte David, Viviana Raquel Guiza-Argueello, Martha L. Arango-Rodriguez, Claudia L. Sossa, Silvia M. Becerra-Bayona
Summary: The absence or damage of tissue is a major cause of diseases, and novel therapeutic alternatives aim to recover lost functions through tissue regeneration. Chronic cutaneous lesions are common wounds that require regenerative medicine and tissue engineering interventions to develop bioactive medical products for proper healing and prevention of complications. The coordination of cells, extracellular matrix (ECM), and biomolecules is crucial in tissue repair and regeneration, with ECM acting as a biological platform for their interactions. Tissue engineering utilizes synthetic polymers and decellularized tissues to mimic native ECM and provide necessary functionalities for cell differentiation.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Zhengzhe Han, Lanlan Dong, Ang Li, Zongyue Li, Landie Fu, Zhichang Zhang, Xiang Li, Xiaolin Li
Summary: This study designed a P-sEVs@hydrogel wound dressing that accelerates angiogenesis and wound healing, achieving fast healing in a full-thickness defect wound model.
MATERIALS TODAY BIO
(2022)
Article
Engineering, Biomedical
Huimin Xiao, Xin Chen, Xuanzhe Liu, Gen Wen, Yaling Yu
Summary: The skin is an important organ that protects the body and interacts with the external environment. Decellularized biomaterials derived from the extracellular matrix have shown potential in promoting wound healing and skin regeneration. This article reviews the wound healing process, the role of extracellular matrix constituents in wound healing, and the various types of decellularized materials used in clinical practice. The challenges and future research directions in utilizing decellularized biomaterials for wound treatment are also discussed.
MATERIALS TODAY BIO
(2023)
Review
Chemistry, Multidisciplinary
Yongping Liang, Jiahui He, Baolin Guo
Summary: Hydrogels have shown promising advantages as wound dressings due to their excellent biochemical and mechanical properties. This review summarizes the advanced functions of hydrogel dressings, such as antimicrobial, adhesion, hemostasis, anti-inflammatory, substance delivery, self-healing, stimulus response, and conductivity, as well as the emerging wound monitoring feature. The potential applications for different types of wounds, including chronic wounds and focus on infected, burn, and diabetic wounds, are discussed, along with proposed future directions for hydrogel wound dressings in wound healing.
Review
Polymer Science
Pavel Yudaev, Yaroslav Mezhuev, Evgeniy Chistyakov
Summary: This review examines the use of dressings containing nanoparticles for wound repair and evaluates their antimicrobial effects and healing actions. The analysis of 31 sources published between 2021 and 2022 demonstrates a trend towards the development of modern antibacterial wound-healing nanomaterials.
Article
Cell Biology
Kellen Chen, Dharshan Sivaraj, Michael F. Davitt, Melissa C. Leeolou, Dominic Henn, Sydney R. Steele, Savana L. Huskins, Artem A. Trotsyuk, Hudson C. Kussie, Autumn H. Greco, Jagannath Padmanabhan, David P. Perrault, Alsu Zamaleeva, Michael T. Longaker, Geoffrey C. Gurtner
Summary: This study compared the effects of different collagen hydrogel dressings on wound healing and found that the material properties of hydrogel dressings can significantly influence healing time, cellular response, and resulting scar architecture.
WOUND REPAIR AND REGENERATION
(2022)
Article
Chemistry, Physical
Nhien Nguyen, Zong-Hong Lin, Snigdha Roy Barman, Chiranjeevi Korupalli, Ji-Yen Cheng, Ni-Xuan Song, Yen Chang, Fwu-Long Mi, Hsiang-Lin Song, Hsing-Wen Sung, Yu-Jung Lin
Summary: This study developed an engineered electroactive dressing that promotes wound healing and monitors the progress in real-time. The dressing transmits bioelectrical signals to stimulate cells and accelerate tissue restoration, while an electrode detects electrical resistance or output current to monitor the overall healing process. The system can be connected to a smartphone for wireless data transmission to medical staff and provide early warnings of potential infections.
Article
Biotechnology & Applied Microbiology
Dong Jun Park, Erika Duggan, Kayla Ho, Robert A. Dorschner, Marek Dobke, John P. Nolan, Brian P. Eliceiri
Summary: Chronic metabolic diseases such as diabetes is associated with delayed wound healing and dysregulated inflammatory phase of wound repair. This study focuses on the changes in extracellular vesicles (EVs) payload that mediates communication between immune cells and stromal cells in the wound bed, which regulate the rate of wound closure. By transferring EVs from genetically defined mouse models, the functional and molecular basis for differences in the pro-reparative biological activity of diabetic (db/db) vs. wildtype EVs in wound healing is demonstrated. This study establishes a novel therapeutic approach by engineering the payload of EVs, aiming to rescue the Serpin deficiency identified by proteomics and promote wound healing in db/db mice.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Lipeng Qiao, Yongping Liang, Jueying Chen, Ying Huang, Saeed A. Alsareii, Abdulrahman Manaa Alamri, Farid A. Harraz, Baolin Guo
Summary: In this study, adhesive self-healing conductive antibacterial hydrogel dressings were prepared for the repair of infected wounds. The hydrogel exhibited self-healing properties, good conductivity, photothermal anti-bacterial properties, and improved wound healing in the infected skin wound repair test. These hydrogels have potential as promising candidates for wound healing dressings for the treatment of infected skin wounds.
BIOACTIVE MATERIALS
(2023)
Article
Polymer Science
Van Anh Thi Le, Tung X. X. Trinh, Pham Ngoc Chien, Nguyen Ngan Giang, Xin-Rui Zhang, Sun-Young Nam, Chan-Yeong Heo
Summary: Hydrocolloid dressings combined with zinc oxide nanoparticles were found to accelerate wound healing rates, reduce inflammation, and promote the proliferation phase of the healing process. This cost-effective and UV-blocking treatment showed significant improvements in both in vivo and in vitro models, providing a promising approach for wound dressing.
Review
Medicine, General & Internal
Nikolai N. Potekaev, Olga B. Borzykh, German V. Medvedev, Denis V. Pushkin, Marina M. Petrova, Artem V. Petrov, Diana V. Dmitrenko, Elena I. Karpova, Olga M. Demina, Natalia A. Shnayder
Summary: Impaired wound healing is a complex issue affecting quality of life and causing economic losses, requiring further research. Understanding the biological and physiological aspects is crucial for finding new treatment methods. Research on the multifactorial role and function of extracellular matrix in skin wound healing shows promising potential for clinical practice.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Huifeng Dong, Liangyu Wang, Lin Du, Xing Wang, Qin Li, Xiaoyue Wang, Jie Zhang, Jun Nie, Guiping Ma
Summary: Developing a multifunctional hydrogel dressing that can adapt to complex and changeable environments, reconstruct skin sensory functions, and provide continuous bactericidal activity is challenging. In this study, a hydrogel dressing based on alginate and polycation was developed, which showed excellent antibacterial properties and accelerated wound healing in a rat model. The hydrogel also demonstrated multiple response modes for strain, pressure, and temperature sensing, providing a smart solution for wound healing and human health monitoring.
Article
Biophysics
Yanwei Li, Tangfeng Wu, Guozheng Zhang, Ai Fang, Yurong Li, Susu Wang, Hui Yan, Peisheng Liang, Jialin Lian, Yeshun Zhang
Summary: In this study, a novel bioactive dressing based on native nondestructive sericin was developed. The dressing was directly secreted by silkworms through regulating their spinning behaviors. It possessed natural structures and bioactivities, as well as a porous fibrous network structure with high air permeability. Furthermore, the dressing showed pH-responsive degradability, softness, super absorbency, and high mechanical strength. It also supported cell viability, proliferation, and migration, and significantly accelerated the healing process in a mouse full-thickness skin wound model. These findings suggest that the sericin wound dressing has promising application and commercial value in wound repair.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Engineering, Biomedical
Loghman Ebrahimi, Ali Samadikuchaksaraei, Mohammad Taghi Joghataei, Majid Safa, Seyyed Meysam Abtahi Froushani, Melina Ghasemian, Samira Zolfaghari, Masoud Mozafari, Peiman Brouki Milan
Summary: Activated macrophages generated by treating circulating monocytes with mesenchymal stem cell (MSC) supernatant show promise in accelerating wound healing. These macrophages not only exhibit immunomodulatory and healing properties, but also demonstrate attachment and proliferation ability on the amniotic membrane scaffold. Transplantation of these activated macrophages using an acellular amniotic membrane carrier significantly improves wound healing in an animal wound model.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2022)
Article
Chemistry, Physical
Seyed Yahya Rahnamaee, Reza Bagheri, Manouchehr Vossoughi, Mona Khafaji, Elham Asadian, Shahab Ahmadi Seyedkhani, Ali Samadikuchaksaraei
Summary: Simultaneous enhancement of osseointegration and bacterial infection prohibition through surface modifications is a challenging but promising approach. A multifunctional surface coating composed of graphene nanolayers and hierarchical well-aligned TiO2 nanotubes (cRTNT) has been shown to significantly improve the biological properties of implants, including enhanced cell activity and reduced bacterial infection.
APPLIED SURFACE SCIENCE
(2022)
Article
Engineering, Biomedical
Zahra Khosrowpour, Seyed Mahmoud Hashemi, Samira Mohammadi-Yeganeh, Mehdi Moghtadaei, Peiman Brouki Milan, Lorenzo Moroni, Subhas C. Kundu, Mazaher Gholipourmalekabadi
Summary: The decellularized placental sponge shows potential as a bone substitute and provides a platform for communication between macrophages and mesenchymal stem cells, guiding the differentiation of stem cells towards bone cells.
Article
Biotechnology & Applied Microbiology
Elnaz Sadat Mirdamadi, Zahra Khosrowpour, Davod Jafari, Mazaher Gholipourmalekabadi, Mehran Solati-Hashjin
Summary: This study used 3D printing technology to fabricate liver scaffolds and investigated the effect of scaffold geometry on liver cell performance. The results showed that the hexagonal design of the scaffold was superior to the square design in terms of cell viability, adhesion, and function. This study is of great importance for liver tissue engineering and regeneration.
BIOTECHNOLOGY AND BIOENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Sanaz Alizadeh, Paniz Farshi, Navid Farahmandian, Zahra Aliakbar Ahovan, Ali Hashemi, Mohammad Majidi, Abdolnaser Azadbakht, Mahsa Darestanifarahani, Koushan Sineh Sepehr, Subhas C. Kundu, Mazaher Gholipourmalekabadi
Summary: A nanofibrous chitosan/poly (vinyl alcohol) (CS/PVA) mat was designed for controlled delivery of antibiotics to treat wound infections. The material showed excellent antibacterial activity against resistant strains and demonstrated good biocompatibility in vitro and in vivo.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Abdolnaser Azadbakht, Sanaz Alizadeh, Zahra Aliakbar Ahovan, Zahra Khosrowpour, Mohammad Majidi, Saeedreza Pakzad, Shahrokh Shojaei, Narendra Pal Singh Chauhan, Marzieh Jafari, Mazaher Gholipourmalekabadi
Summary: A thermos-responsive hydrogel wound dressing with excellent biological properties is developed by incorporating solubilized placental extracellular matrix (ECM). The hydrogel with a higher ECM concentration demonstrates better cell adhesion and angiogenic properties.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Instruments & Instrumentation
Naser Amini, Ahmad Hivechi, Shiva Asadpour, Kaveh Ebrahimzadeh, Saeid Kargozar, Mazaher Gholipourmalekabadi, Ahvan Nasrolahi, Melina Ghasemian, Amir Shafaat, Masoud Mozafari, Peiman Brouki Milan, Alireza Rezapour
Summary: This study investigated the use of a novel biomimetic hybrid scaffold for skin regeneration, which continuously delivered stromal cell-derived factor-1 alpha (SDF-1 alpha). The scaffold demonstrated biocompatibility and its release of SDF-1 alpha was assessed. In diabetic rat models, the scaffold with SDF-1 alpha showed a significantly enhanced ability for wound regeneration and recruitment of CD31 and CXCR4-positive cells. The study concluded that the hybrid scaffold based on natural polymer offers a new option for topical administration of bioactive molecules and holds promise for skin tissue engineering.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Hatef Ghasemi Hamidabadi, Sanaz Alizadeh, Leila Mahboobi, Zahra Khosrowpour, Maryam Nazm Bojnordi, Zahra Aliakbar Ahovan, Majid Malekzadeh Shafaroudi, Maria Zahiri, Narendra Pal Singh Chauhan, Mazaher Gholipourmalekabadi
Summary: In this study, a biological-based sponge made from decellularized human placenta was loaded with different concentrations of an antimicrobial peptide to optimize an ideal antibacterial wound dressing. The sponge showed strong antibacterial activity against extensively drug-resistant bacteria, with the highest effect observed at a concentration of 64 μg/mL. Animal experiments demonstrated excellent in vivo biocompatibility of the material.
Article
Pharmacology & Pharmacy
Vahid Reisi-Vanani, Samanesadat Hosseini, Ebrahim Soleiman-Dehkordi, Sahand Noaien Boroujeni, Mahour Farzan, Valentina Virginia Ebani, Mazaher Gholipourmalekabadi, Karen Lozano, Zahra Lorigooini
Summary: This study evaluated the synergistic effect of thymus essential oil and licorice extract on wound healing applications. The developed nanocomposite fibers exhibited antibacterial activity, promoted fibroblast proliferation, and facilitated wound healing.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Engineering, Biomedical
Bahar Asadi, Hamid Mirzadeh, Nafiseh Olov, Ali Samadikuchaksaraei, Raheleh Kheirbakhsh, Roshanak Moradi, Saeid Amanpour, Shadab Bagheri-Khoulenjani
Summary: This study focuses on using cryogelation as a versatile method to fabricate biomimetic scaffolds with improved mechanical strength and larger pore size, with potential for bone tissue engineering applications.
BIOINSPIRED BIOMIMETIC AND NANOBIOMATERIALS
(2023)
Article
Genetics & Heredity
Reyhaneh Nassiri Mansour, Elham Hasanzadeh, Mozhgan Abasi, Mazaher Gholipourmalekabadi, Amir Mellati, Seyed Ehsan Enderami
Summary: Combining fetal bovine acellular dermal matrix (FADM) with human Wharton's jelly mesenchymal stem cells (hWJ-MSCs) can promote the healing of full-thickness skin wounds. The FADM-WJMSC group showed a higher wound closure rate and fewer inflammatory cells compared to the control and FADM groups. These findings suggest the potential application value of combining FADM with hWJ-MSCs in the treatment of skin wounds.
Article
Engineering, Biomedical
Zahra Bashiri, Motahareh Rajabi Fomeshi, Hatef Ghasemi Hamidabadi, Davod Jafari, Sanaz Alizadeh, Maryam Nazm Bojnordi, Gorka Orive, Alireza Dolatshahi-Pirouz, Maria Zahiri, Rui L. Reis, Subhas C. Kundu, Mazaher Gholipourmalekabadi
Summary: Extracellular matrix (ECM)-based bioinks are widely studied for 3D printing of native-like tissue constructs. In this study, a printable bioink biomimicking natural skin was prepared using different concentrations of placental ECM, sodium-alginate, and gelatin. The 5% ECM 3D printed scaffold showed the best deep wound regeneration, producing a skin replacement with a cellular structure comparable to native skin.
MATERIALS TODAY BIO
(2023)
Article
Biotechnology & Applied Microbiology
Mohammad Majidi, Saeedreza Pakzad, Maryam Salimi, Abdolnaser Azadbakht, Saieh Hajighasemlou, Moein Amoupour, Zeinab Nokhbedehghan, Shahin Bonakdar, Koushan Sineh Sepehr, Narendra Pal Singh Chauhan, Mazaher Gholipourmalekabadi
Summary: Cell morphology and topological cues have significant impacts on the functions of mesenchymal stem cells and macrophages, which are crucial for biomaterial implantation and wound healing. Study showed that cell-imprinted surfaces could induce the polarization of macrophages towards anti-inflammatory phenotypes. Therefore, wound dressings with M2 cell morphology-induced surfaces are suggested as excellent options for anti-inflammatory and anti-scarring effects.
BIOTECHNOLOGY AND BIOENGINEERING
(2023)
