Structural Dynamics of Protein Interactions Using Site-Directed Spin Labeling of Cysteines to Measure Distances and Rotational Dynamics with EPR Spectroscopy

HTS driven by fluorescence lifetime detection of FRET identifies activators and inhibitors of cardiac myosin

(2023) JM Muretta et al.   SLAS Discovery

Cyclers’ kinases in cell division: from molecules to cancer therapy

(2023) Giacomo Milletti et al.   CELL DEATH AND DIFFERENTIATION

A Large-Scale High-Throughput Screen for Modulators of SERCA Activity

(2022) Philip A. Bidwell et al.   Biomolecules

Nothing Regular about the Regulins: Distinct Functional Properties of SERCA Transmembrane Peptide Regulatory Subunits

(2021) Nishadh Rathod et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Atomistic Models from Orientation and Distance Constraints Using EPR of a Bifunctional Spin Label

(2019) Benjamin P. Binder et al.   BIOPHYSICAL JOURNAL

Myosin lever arm orientation in muscle determined with high angular resolution using bifunctional spin labels

(2019) Yahor Savich et al.   JOURNAL OF GENERAL PHYSIOLOGY

Dynamics of Dystrophin’s Actin-Binding Domain

(2018) Michael E. Fealey et al.   BIOPHYSICAL JOURNAL

A dynamic mechanism for allosteric activation of Aurora kinase A by activation loop phosphorylation

(2018) Emily F Ruff et al.   eLife

Structural dynamics of calmodulin-ryanodine receptor interactions: electron paramagnetic resonance using stereospecific spin labels

(2018) Cheng Her et al.   Scientific Reports

Quantitative conformational profiling of kinase inhibitors reveals origins of selectivity for Aurora kinase activation states

(2018) Eric W. Lake et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for high-affinity actin binding revealed by a β-III-spectrin SCA5 missense mutation

(2017) Adam W. Avery et al.   Nature Communications

Calcium-Dependent Structural Dynamics of a Spin-Labeled RyR Peptide Bound to Calmodulin

(2016) Cheng Her et al.   BIOPHYSICAL JOURNAL

A bifunctional spin label reports the structural topology of phospholamban in magnetically-aligned bicelles

(2016) Jesse E. McCaffrey et al.   JOURNAL OF MAGNETIC RESONANCE

Site-directed spectroscopy of cardiac myosin-binding protein C reveals effects of phosphorylation on protein structural dynamics

(2016) Brett A. Colson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A human β-III-spectrin spinocerebellar ataxia type 5 mutation causes high-affinity F-actin binding

(2016) Adam W. Avery et al.   Scientific Reports

Impact of methionine oxidation on calmodulin structural dynamics

(2015) Megan R. McCarthy et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

High-resolution helix orientation in actin-bound myosin determined with a bifunctional spin label

(2015) Benjamin P. Binder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Technological advances in site-directed spin labeling of proteins

(2013) Wayne L Hubbell et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

DEER Distance Measurements on Proteins

(2012) Gunnar Jeschke   Annual Review of Physical Chemistry

Conformationally Trapping the Actin-binding Cleft of Myosin with a Bifunctional Spin Label

(2012) Rebecca J. Moen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis for the Regulation of Protein Kinase A by Activation Loop Phosphorylation

(2012) Jon M. Steichen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure and dynamics of a conformationally constrained nitroxide side chain and applications in EPR spectroscopy

(2011) M. R. Fleissner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Large-scale opening of utrophin's tandem calponin homology (CH) domains upon actin binding by an induced-fit mechanism

(2011) A. Y. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation-induced structural changes in smooth muscle myosin regulatory light chain

(2010) D. Kast et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeted deletion of  III spectrin impairs synaptogenesis and generates ataxic and seizure phenotypes

(2010) M. C. Stankewich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stabilization of N-Myc Is a Critical Function of Aurora A in Human Neuroblastoma

(2009) Tobias Otto et al.   CANCER CELL

Dystrophin and utrophin have distinct effects on the structural dynamics of actin

(2009) E. Prochniewicz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural dynamics of the myosin relay helix by time-resolved EPR and FRET

(2009) R. V. Agafonov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Dynamics of the Actomyosin Complex Probed by a Bifunctional Spin Label that Cross-Links SH1 and SH2

(2008) Andrew R. Thompson et al.   BIOPHYSICAL JOURNAL

Thermodynamic and Structural Basis of Phosphorylation-Induced Disorder-to-Order Transition in the Regulatory Light Chain of Smooth Muscle Myosin

(2008) L. Michel Espinoza-Fonseca et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Actin-binding cleft closure in myosin II probed by site-directed spin labeling and pulsed EPR

(2008) J. C. Klein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA