Platelet-Derived Exosomes Alleviate Knee Osteoarthritis by Attenuating Cartilage Degeneration and Subchondral Bone Loss

Deletion of DYRK1A Accelerates Osteoarthritis Progression Through Suppression of EGFR-ERK Signaling

(2023) Zhibo Liu et al.   INFLAMMATION

Exosomes Derived From Human Urine–Derived Stem Cells Overexpressing miR-140-5p Alleviate Knee Osteoarthritis Through Downregulation of VEGFA in a Rat Model

(2022) Yuan Liu et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

Exosomes rewire the cartilage microenvironment in osteoarthritis: from intercellular communication to therapeutic strategies

(2022) Yuangang Wu et al.   International Journal of Oral Science

Efficacy and Tolerability of Topical Platelet Exosomes for Skin Rejuvenation: Six-Week Results

(2022) Sydney L Proffer et al.   Aesthetic Surgery Journal

Research progress in the use of mesenchymal stem cells and their derived exosomes in the treatment of osteoarthritis

(2022) Hongxia Yu et al.   AGEING RESEARCH REVIEWS

Platelet-Derived Extracellular Vesicles for Regenerative Medicine

(2021) Miquel Antich-Rosselló et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Characterization and Therapeutic Use of Extracellular Vesicles Derived from Platelets

(2021) Timea Spakova et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cell-autonomous inflammation of BRCA1-deficient ovarian cancers drives both tumor-intrinsic immunoreactivity and immune resistance via STING

(2021) Marine Bruand et al.   Cell Reports

Ablation of PKM2 ameliorated ER stress‐induced apoptosis and associated inflammation response in IL‐1β‐treated chondrocytes via blocking Rspo2‐mediated Wnt/β‐catenin signaling

(2020) Zhi Zhou Li et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Platelet-derived microparticles mediate the intra-articular homing of mesenchymal stem cells in early-stage cartilage lesions

(2020) Chi Liang et al.   STEM CELLS AND DEVELOPMENT

The Landscape of Coding and Non-coding RNAs in Platelets

(2020) Clemens Gutmann et al.   ANTIOXIDANTS & REDOX SIGNALING

Screening on platelet LncRNA expression profile discloses novel residual platelet reactivity biomarker

(2020) Shaodi Yan et al.   International Journal of Laboratory Hematology

Platelet microparticles load a repertory of miRNAs programmed to drive osteogenic phenotype

(2020) Marcel Rodrigues Ferreira et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Prospective Therapeutic Applications of Platelet Extracellular Vesicles

(2020) Jancy Johnson et al.   TRENDS IN BIOTECHNOLOGY

miR-100-5p-abundant exosomes derived from infrapatellar fat pad MSCs protect articular cartilage and ameliorate gait abnormalities via inhibition of mTOR in osteoarthritis

(2019) Jiangyi Wu et al.   BIOMATERIALS

Modulation of the Wnt pathway through inhibition of CLK2 and DYRK1A by lorecivivint as a novel, potentially disease-modifying approach for knee osteoarthritis treatment

(2019) V. Deshmukh et al.   OSTEOARTHRITIS AND CARTILAGE

Platelet-derived- Extracellular Vesicles Promote Hemostasis and Prevent the Development of Hemorrhagic Shock

(2019) Ernesto Lopez et al.   Scientific Reports

Platelet-Derived Exosomal MicroRNA-25-3p Inhibits Coronary Vascular Endothelial Cell Inflammation Through Adam10 via the NF-κB Signaling Pathway in ApoE−/− Mice

(2019) Ye Yao et al.   Frontiers in Immunology

Polyamine regulator AMD1 promotes cell migration in epidermal wound healing

(2018) Lim Hui Kheng et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

HSP60 critically regulates endogenous IL-1β production in activated microglia by stimulating NLRP3 inflammasome pathway

(2018) Shalini Swaroop et al.   Journal of Neuroinflammation

Early Changes of Articular Cartilage and Subchondral Bone in The DMM Mouse Model of Osteoarthritis

(2018) Hang Fang et al.   Scientific Reports

Platelet-derived Extracellular Vesicles: An Emerging Therapeutic Approach

(2017) Shi-Cong Tao et al.   International Journal of Biological Sciences

mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer

(2017) Amaia Zabala-Letona et al.   NATURE

Intra-articular injection of microRNA-140 (miRNA-140) alleviates osteoarthritis (OA) progression by modulating extracellular matrix (ECM) homeostasis in rats

(2017) H.-b. Si et al.   OSTEOARTHRITIS AND CARTILAGE

Thrombin-activated platelet-derived exosomes regulate endothelial cell expression of ICAM-1 via microRNA-223 during the thrombosis-inflammation response

(2017) Jiannan Li et al.   THROMBOSIS RESEARCH

Exosomes derived from human platelet-rich plasma prevent apoptosis induced by glucocorticoid-associated endoplasmic reticulum stress in rat osteonecrosis of the femoral head via the Akt/Bad/Bcl-2 signal pathway

(2017) Shi-Cong Tao et al.   Theranostics

Exosomes derived from platelet-rich plasma promote the re-epithelization of chronic cutaneous wounds via activation of YAP in a diabetic rat model

(2017) Shang-Chun Guo et al.   Theranostics

Osteoarthritis: toward a comprehensive understanding of pathological mechanism

(2017) Di Chen et al.   Bone Research

Plasma exosomal miR-223 expression regulates inflammatory responses during cardiac surgery with cardiopulmonary bypass

(2017) Kin-Shing Poon et al.   Scientific Reports

HSP60 plays a regulatory role in IL-1β-induced microglial inflammation via TLR4-p38 MAPK axis

(2016) Shalini Swaroop et al.   Journal of Neuroinflammation

Metabolites in stored platelets associated with platelet recoveries and survivals

(2016) James C. Zimring et al.   TRANSFUSION

The anti-inflammatory effects of platelet-derived microparticles in human plasmacytoid dendritic cells involve liver X receptor activation

(2015) A. Ceroi et al.   HAEMATOLOGICA

Osteoarthritis

(2015) S Glyn-Jones et al.   LANCET

The anti-inflammatory effects of platelet-derived microparticles in human plasmacytoid dendritic cells involve liver X receptor activation

(2015) A. Ceroi et al.   HAEMATOLOGICA

Synergistic anabolic actions of hyaluronic acid and platelet-rich plasma on cartilage regeneration in osteoarthritis therapy

(2014) Wei-Hong Chen et al.   BIOMATERIALS

Exosomes/miRNAs as mediating cell-based therapy of stroke

(2014) Hongqi Xin et al.   Frontiers in Cellular Neuroscience

Platelet-rich plasma in patients with tibiofemoral cartilage degeneration

(2013) Radek Hart et al.   ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY

Amelioration of arthritis through mobilization of peptide-specific CD8+ regulatory T cells

(2013) Jianmei W. Leavenworth et al.   JOURNAL OF CLINICAL INVESTIGATION

Applications of Leukocyte- and Platelet-Rich Plasma (L-PRP) in Trauma Surgery

(2012) Ting Yuan et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Microparticles (Ectosomes) Shed by Stored Human Platelets Downregulate Macrophages and Modify the Development of Dendritic Cells

(2011) S. Sadallah et al.   JOURNAL OF IMMUNOLOGY

Platelet Microparticles Enhance the Vasoregenerative Potential of Angiogenic Early Outgrowth Cells After Vascular Injury

(2010) Sebastian F. Mause et al.   CIRCULATION

Pharmacologic therapy for osteoarthritis—the era of disease modification

(2010) David J. Hunter   Nature Reviews Rheumatology

Osteoarthritis in the context of ageing and evolution

(2007) Peter M. van der Kraan et al.   AGEING RESEARCH REVIEWS