☆ 4.4 Letter

The anti-inflammatory effects of platelet-derived microparticles in human plasmacytoid dendritic cells involve liver X receptor activation

HAEMATOLOGICA (2016)

期刊

HAEMATOLOGICA

卷 101, 期 3, 页码 E72-E76

出版社

FERRATA STORTI FOUNDATION

DOI: 10.3324/haematol.2015.135459

关键词

LXR; plasmacytoid dendritic cells; ectosomes; extracellular vesicles; microvesicles; inflammation

类别

Hematology

向作者/读者索取更多资源

Protocol

Reagent

作者

我是这篇论文的作者

点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.4

评分不足

次要评分

新颖性

-

重要性

-

科学严谨性

-

评价这篇论文

推荐

Review Medicine, Research & Experimental

Extracellular Vesicles and Circulating Tumour Cells-complementary liquid biopsies or standalone concepts

Artur Slomka, Bingduo Wang, Tudor Mocan, Adelina Horhat, Arnulf G. Willms, Ingo G. H. Schmidt-Wolf, Christian P. Strassburg, Maria A. Gonzalez-Carmona, Veronika Lukacs-Kornek, Miroslaw T. Kornek

Summary: Liquid biopsies, as biomarkers in cancer diagnosis, have great potential but also limitations. This review focuses on comparing extracellular vesicles (EVs) and circulating tumor cells (CTCs) and discussing their similarities in characterization and quantification. While it is not concluded which is better between CTCs and EVs, the review provides reasons to intensify research on both.

THERANOSTICS (2022)

添加到收藏夹

Review Physiology

Extracellular Vesicles as Central Mediators of COPD Pathophysiology

Derek W. Russell, Kristopher R. Genschmer, J. Edwin Blalock

Summary: Chronic obstructive pulmonary disease (COPD) is a complex smoking-related disease driven by interrelated processes. Extracellular vesicles (EVs) are powerful effectors that could play a significant role in COPD pathogenesis.

ANNUAL REVIEW OF PHYSIOLOGY (2022)

添加到收藏夹

Article Oncology

Targeting of tumor cells by custom antigen transfer: a novel approach for immunotherapy of cancer

Ilaria Nesi, Chiara Della Bella, Maria Letizia Taddei, Alice Santi, Erica Pranzini, Paolo Paoli, Mario Milco D'Elios, Matteo Ramazzotti, Massimo Genovese, Anna Caselli, Paolo Cirri

Summary: Early-stage tumors become invisible to the immune system, and clinical treatments become ineffective when the immune system fails. Restoring the natural anti-tumor role of the immune system could be a promising approach for cancer treatment.

FRONTIERS IN ONCOLOGY (2023)

添加到收藏夹

Editorial Material Cell Biology

Updating MISEV: Evolving the minimal requirements for studies of extracellular vesicles

Kenneth W. Witwer, Deborah C. Goberdhan, Lorraine O'Driscoll, Clotilde Thery, Joshua A. Welsh, Cherie Blenkiron, Edit Buzas, Dolores Di Vizio, Uta Erdbrugger, Juan M. Falcon-Perez, Qing-Ling Fu, Andrew F. Hill, Metka Lenassi, Jan Lotvall, Rienk Nieuwland, Takahiro Ochiya, Sophie Rome, Susmita Sahoo, Lei Zheng

Summary: The MISEV initiative by ISEV aims to advance EV science globally, with the 2018 release of MISEV2018 providing comprehensive recommendations on EV nomenclature, sample processing, separation concentration, characterization, functional studies, and reporting requirements, with input from over 400 scientists. ISEV sought feedback and opinions from the community through a survey to better formulate MISEV and address key issues.

JOURNAL OF EXTRACELLULAR VESICLES (2021)

添加到收藏夹

Article Chemistry, Analytical

Anti-Tim4 Grafting Strongly Hydrophilic Metal-Organic Frameworks Immunoaffinity Flake for High-Efficiency Capture and Separation of Exosomes

Lei Zhang, Haiyan Wang, Guofa Zhao, Nan Li, Xiaofang Wang, Yumiao Li, Youchao Jia, Xiaoqiang Qiao

Summary: Exosomes, carrying a large amount of genetic materials, have become the most ideal analysis target for liquid biopsy. A novel Tim4@ILI-01 immunoaffinity material with high capture efficiency and easy release of captured exosomes has been successfully designed and developed, showing great potential for practical clinical applications in cancer diagnosis and prognosis.

ANALYTICAL CHEMISTRY (2021)

添加到收藏夹

Review Cell Biology

Extracellular Vesicles Linking Inflammation, Cancer and Thrombotic Risks

Sarah Beck, Bernhard Hochreiter, Johannes A. Schmid

Summary: Extracellular vesicles (EVs) play crucial roles in intercellular communication by transferring nucleotides and proteins, and are associated with diseases such as cancer, inflammation, and thrombosis. They have the potential to serve as biomarkers for diagnosis and as vehicles for therapeutics in the future.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

添加到收藏夹

Article Immunology

Extracellular vesicles from A23187-treated neutrophils cause cGAS-STING-dependent IL-6 production by macrophages

Edwina R. Allen, Kaitlyn M. Whitefoot-Keliin, Ellen M. Palmatier, Andrew R. Mahon, Mallary C. Greenlee-Wacker

Summary: This study demonstrates that neutrophils regulate inflammatory response by releasing extracellular vesicles (EVs) and DNA. A23187-EVs induce macrophage inflammation through cGAS-STING-dependent IL-6 production, while EVs from untreated cells do not exhibit pro-inflammatory activity.

FRONTIERS IN IMMUNOLOGY (2022)

添加到收藏夹

Review Oncology

Extracellular Vesicles in Colorectal Cancer: From Tumor Growth and Metastasis to Biomarkers and Nanomedications

Larissa Kotelevets, Eric Chastre

Summary: Extracellular vesicles, such as exosomes, ectosomes, and apoptotic bodies, play a critical role in intercellular communication and can be used for noninvasive diagnosis of cancer. They can also be engineered for efficient delivery of therapeutic agents for tumor treatment. This review highlights the importance of extracellular vesicles in colorectal cancer progression, diagnosis, and potential therapeutic approaches.

CANCERS (2023)

添加到收藏夹

Article Multidisciplinary Sciences

Effects of lysate/tissue storage at -80°C on subsequently extracted EVs of epithelial ovarian cancer tissue origins

Shizhen Shen, Zhangjin Shen, Conghui Wang, Xiaodong Wu, Lingfang Wang, Lele Ye, Songfa Zhang, Xiaodong Cheng

Summary: In this study, a method for extracting extracellular vesicles (EVs) from epithelial ovarian cancer (EOC) tissues was optimized to investigate the effect of cryopreservation on the phenotypes, contents, and biological functions of the extracted EVs. The results showed that cryopreservation affected the yield and distribution of EVs, but not their morphology or particle mass ratio. The storage of tissues at -80°C increased both small and large EV yields, while the storage of lysates at -80°C decreased large EV yield and increased small EV yield. The cryopreserved EOC tissue retained a high percentage of proteins and miRNAs, and the extracted EVs could promote angiogenesis and invasive migration ability in human endothelial cells. This suggests that cryopreserved EOC tissue has clinical value for studying tissue-derived EVs, especially those related to EV proteins.

ISCIENCE (2023)

添加到收藏夹

Article Biochemical Research Methods

Towards nanovesicle-based disease diagnostics: a rapid single-step exosome assay within one hour through in situ immunomagnetic extraction and nanophotonic label-free detection

Qinming Zhang, Hannah J. Loghry, Jingjing Qian, Michael J. Kimber, Liang Dong, Meng Lu

Summary: This paper introduces a unique exosome assay technology that combines magnetic nanoparticle-based exosome extraction and photonic crystal-based label-free exosome detection in a single vessel within one hour, with improved sensitivity and selectivity. The high specificity is achieved by functionalizing both nanoparticles and photonic crystals with specific antibodies, resulting in a low limit of detection and high enrichment factor for exosomes. The method is validated for analyzing membrane proteins of exosomes with high selectivity and sensitivity, showing great potential for exosome-based disease diagnostics.

LAB ON A CHIP (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Do Extracellular Vesicles Derived from Mesenchymal Stem Cells Contain Functional Mitochondria?

Ljubava D. Zorova, Sergei I. Kovalchuk, Vasily A. Popkov, Valery P. Chernikov, Anastasia A. Zharikova, Anastasia A. Khutornenko, Savva D. Zorov, Konstantin S. Plokhikh, Roman A. Zinovkin, Ekaterina A. Evtushenko, Valentina A. Babenko, Irina B. Pevzner, Yulia A. Shevtsova, Kirill V. Goryunov, Egor Y. Plotnikov, Denis N. Silachev, Gennady T. Sukhikh, Dmitry B. Zorov

Summary: Extracellular vesicles derived from stem cells have been widely studied for their potential use in cell therapy. This study examined two fractions of vesicles derived from mesenchymal stromal stem cells and found the presence of mitochondrial components in these vesicles. However, it is still unclear whether these mitochondria are fully functional inside the vesicles.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

添加到收藏夹

Article Engineering, Biomedical

Growth Media Conditions Influence the Secretion Route and Release Levels of Engineered Extracellular Vesicles

Jeremy P. Bost, Osama Saher, Daniel Hagey, Doste R. Mamand, Xiuming Liang, Wenyi Zheng, Giulia Corso, Oskar Gustafsson, Andre Gorgens, Ci Edvard Smith, Rula Zain, Samir El Andaloussi, Dhanu Gupta

Summary: Extracellular vesicles (EVs) are nanosized cell-derived vesicles that facilitate intercellular communication via transmitting biological cargo. The production of EVs is influenced by various pathways and external factors in the cell media, with ceramide-dependent pathway being a major contributor to engineered EV production. The study provides insights into understanding and optimizing EV production in cell culture for developing advanced methods.

ADVANCED HEALTHCARE MATERIALS (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

Extracellular Vesicles for Therapeutic Nucleic Acid Delivery: Loading Strategies and Challenges

Anastasiya Oshchepkova, Marina Zenkova, Valentin Vlassov

Summary: Extracellular vesicles (EVs) are released by cells and contain various biological cargoes, providing advantages over synthetic carriers for drug delivery. This review discusses the use of EVs as carriers for therapeutic nucleic acids (tNAs), the challenges faced in vivo, and strategies for tNA loading into EVs.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

添加到收藏夹

Article Toxicology

Microvesicle-Derived miRNAs Regulate Proinflammatory Macrophage Activation in the Lung Following Ozone Exposure

Jonathan M. Carnino, Heedoo Lee, Ley Cody Smith, Vasanthi R. Sunil, Raymond C. Rancourt, Kinal Vayas, Jessica Cervelli, Zhi Hao Kwok, Kareemah Ni, Jeffrey D. Laskin, Yang Jin, Debra L. Laskin

Summary: Ozone exposure leads to increased levels of extracellular vesicles (EVs) and altered microRNA (miRNA) profiles in lung macrophages, promoting inflammatory responses. The miRNA cargo in EVs derived from ozone-exposed mice regulates pathways that contribute to macrophage activation and inflammatory protein expression. These findings highlight a novel mechanism by which ozone exposure influences macrophage inflammatory responses through EV-derived miRNAs.

TOXICOLOGICAL SCIENCES (2022)

添加到收藏夹

Article Critical Care Medicine

EXOSOMES AND MICROVESICLES FROM ADIPOSE-DERIVED MESENCHYMAL STEM CELLS PROTECTS THE ENDOTHELIAL GLYCOCALYX FROM LPS INJURY

Sharven Taghavi, Sarah Abdullah, Farhana Shaheen, Jacob Packer, Juan Duchesne, Stephen E. Braun, Chad Steele, Derek Pociask, Jay K. Kolls, Olan Jackson-Weaver

Summary: Exosomes and microvesicles derived from adipose-derived mesenchymal stem cells (ASCs) can protect the endothelial glycocalyx from LPS injury, potentially through the action of a specific enzyme.

SHOCK (2023)

添加到收藏夹

Review Immunology

Cholesterol and HIF-1α: Dangerous Liaisons in Atherosclerosis

Charles Thomas, Damien Leleu, David Masson

Summary: HIF-1α plays a dual role in atherosclerosis, with both detrimental and beneficial effects. Its impact depends on the cell type expressing HIF-1α, and it can be stabilized by oxLDLs and oxysterols, leading to various responses including inflammation, angiogenesis, and metabolic reprogramming. Additionally, HIF-1α promotes the accumulation of cholesterol and triglycerides in macrophages.

FRONTIERS IN IMMUNOLOGY (2022)

添加到收藏夹

Article Immunology

Human Monocyte-Derived Suppressor Cell Supernatant Induces Immunoregulatory Effects and Mitigates xenoGvHD

Claire Gerard, Marine Thebault, Baptiste Lamarthee, Coraline Genet, Florine Cattin, Andrea Brazdova, Nona Janikashvili, Claudie Cladiere, Marion Ciudad, Sethi Ouandji, Thibault Ghesquiere, Helene Greigert, Claire Tinel, Olivier Adotevi, Philippe Saas, Maxime Samson, Sylvain Audia, Bernard Bonnotte

Summary: Recently developed cell-based therapies have shown potential for mitigating graft-versus-host disease (GvHD). CD14+HuMoSC supernatant can reduce GvHD symptoms by inhibiting T cell proliferation and CD8 cell activity, and it can also maintain its immunosuppressive properties in an inflammatory environment.

FRONTIERS IN IMMUNOLOGY (2022)

添加到收藏夹

Article Pharmacology & Pharmacy

GPIHBP1 autoantibody is an independent risk factor for the recurrence of hypertriglyceridemia-induced acute pancreatitis

Michel Farnier, Frederic Chague, Maud Maza, Florence Bichat, David Masson, Yves Cottin, Marianne Zeller

Summary: A study on acute myocardial infarction patients in France showed that very high levels of Lp(a) are independently associated with a severe burden of coronary artery disease, supporting the need for systematic screening of Lp(a) in these patients.

JOURNAL OF CLINICAL LIPIDOLOGY (2022)

添加到收藏夹

Article Oncology

Interplay between plasmacytoid dendritic cells and tumor-specific T cells in peripheral blood influences long-term survival in non-small cell lung carcinoma

Caroline Laheurte, Evan Seffar, Eleonore Gravelin, Julie Lecuelle, Adeline Renaudin, Laura Boullerot, Marine Malfroy, Amelie Marguier, Benoit Lecoester, Beatrice Gaugler, Philippe Saas, Caroline Truntzer, Francois Ghiringhelli, Olivier Adotevi

Summary: Plasmacytoid dendritic cells (pDCs) in non-small cell lung cancer patients have been shown to have an ambivalent role in cancer immunity. Higher levels of circulating pDCs are associated with improved overall survival (OS) in NSCLC, especially in early-stage patients, and a high pDC signature in the tumor microenvironment predicts better efficacy of immune checkpoint inhibitors in these patients.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2023)

添加到收藏夹

Article Dermatology

Resolved Psoriasis with Abundant Oleic Acid in Stratum Corneum Exhibits Lower T-Cell-Driven IL-17 Signature

Yasmin El Mahi, Alexis Varin, Mathieu Vetter, Ludivine Dal Zuffo, Loic Mazzeo, Jean-Paul Pais De Barros, Francois Aubin, Philippe Saas, Irene Gallais Serezal

Summary: The relapses of psoriasis are related to T cells that reside in the skin, with the fatty acid intake capacity of tissue-resident memory T cells playing a crucial role in their function. The composition of fatty acids in the skin is linked to the functions of epidermal T cells and may affect the severity of psoriasis.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2023)

添加到收藏夹

Article Medicine, Research & Experimental

HDL therapy for acute graft-versus-host disease

Etienne Daguindau, Cecile Chague, Philippe Saas

M S-MEDECINE SCIENCES (2023)

添加到收藏夹

Editorial Material Immunology

Editorial: Hypoxia and inflammation: A two-way street

Philippe Saas, Guo-Chang Fan

FRONTIERS IN IMMUNOLOGY (2023)

添加到收藏夹

Article Immunology

Human monocyte-derived suppressive cells (HuMoSC) for cell therapy in giant cell arteritis

Maxime Samson, Coraline Genet, Marc Corbera-Bellalta, Helene Greigert, Georgina Espigol-Frigole, Claire Gerard, Claudie Cladiere, Roser Alba-Rovira, Marion Ciudad, Pierre-Henry Gabrielle, Catherine Creuzot-Garcher, Georges Tarris, Laurent Martin, Philippe Saas, Sylvain Audia, Bernard Bonnotte, Maria C. Cid

Summary: This study evaluated the effect of Human Monocyte-derived Suppressor Cells (HuMoSC) on inflammation and vascular remodeling in Giant Cell Arteritis (GCA) treatment. The results showed that HuMoSCs or their supernatant could decrease vascular inflammation and remodeling, which may address the unmet need in GCA treatment.

FRONTIERS IN IMMUNOLOGY (2023)

添加到收藏夹

Review Oncology

Dendritic Cell Subsets in Melanoma: Pathophysiology, Clinical Prognosis and Therapeutic Exploitation

Eleonora Sosa Cuevas, Philippe Saas, Caroline Aspord

Summary: Immunotherapies using immune checkpoint blockers have shown clinical success in melanoma, but some patients still relapse or do not respond. Dendritic cells (DCs) play a key role in immune responses and their understanding is important for developing effective immunotherapies. This review provides an overview of DC diversity, their role in melanoma pathophysiology and clinical outcomes, tumor-induced DC subversion mechanisms, and DC-based therapeutic developments.

CANCERS (2023)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Inflammation and oxidative stress markers in type 2 diabetes patients with Advanced Carotid atherosclerosis

Louise Menegaut, Aline Laubriet, Valentin Crespy, Damien Leleu, Thomas Pilot, Kevin Van Dongen, Jean-Paul Pais de Barros, Thomas Gautier, Jean-Michel Petit, Charles Thomas, Maxime Nguyen, Eric Steinmetz, David Masson

Summary: This study aimed to investigate the increase of 2-AA-LPC in carotid plaques from T2DM and control patients and explore its association with plaque vulnerability and biomarkers altered during diabetes. The results showed that 2-AA-LPC was significantly enriched in plaques from diabetic patients and correlated with inflammatory markers within the plaques. This highlights the involvement of local inflammation, arachidonic acid metabolism, and diabetes in the pathogenesis of atherosclerosis.

CARDIOVASCULAR DIABETOLOGY (2023)

添加到收藏夹

Article Immunology

Pre-transplant immune profile defined by principal component analysis predicts acute rejection after kidney transplantation

Emilie Gaiffe, Mathilde Colladant, Maxime Desmaret, Jamal Bamoulid, Franck Leroux, Caroline Laheurte, Sophie Brouard, Magali Giral, Philippe Saas, Cecile Courivaud, Nicolas Degauque, Didier Ducloux

Summary: Unsupervised hierarchical clustering analysis was performed on pre-transplant immunological phenotype in 1113 renal transplant recipients, identifying three immune profiles correlated with clinical phenotypes. The memory immune cluster was associated with older age and diabetes, while the activated immune cluster was associated with younger age and previous exposure to CMV. Both were associated with an increased risk of acute rejection.

FRONTIERS IN IMMUNOLOGY (2023)

添加到收藏夹

Article Medicine, General & Internal

Transfused Red Blood Cell Characteristics and Kidney Transplant Outcomes Among Patients Receiving Early Posttransplant Transfusion

Emilie Gaiffe, Dewi Vernerey, Laurent Bardiaux, Franck Leroux, Aurelia Meurisse, Jamal Bamoulid, Cecile Courivaud, Philippe Saas, Marc Hazzan, Pierre Tiberghien, Didier Ducloux

Summary: A longer storage duration of red blood cells (RBC) was associated with a decreased risk of transplant failure among patients who received kidney transplants and RBC transfusions. Preferential use of RBC with longer storage duration might improve kidney graft survival following transplant and transfusion.

JAMA NETWORK OPEN (2023)

添加到收藏夹

Article Rheumatology

Increased gut permeability and intestinal inflammation precede arthritis onset in the adjuvant-induced model of arthritis

Sophie Hecquet, Perle Totoson, Helene Martin, Marie-Paule Algros, Philippe Saas, Jean-Paul Pais-de-Barros, Alban Atchon, Benoit Valot, Didier Hocquet, Maude Tournier, Clement Prati, Daniel Wendling, Celine Demougeot, Frank Verhoeven

Summary: Intestinal inflammation and alterations of the intestinal barrier are not the consequence of joint damage, and intestinal changes occurred in the absence of bacterial translocation.

ARTHRITIS RESEARCH & THERAPY (2023)

添加到收藏夹

Article Immunology

Melanoma tumour-derived glycans hijack dendritic cell subsets through C-type lectin receptor binding

Camille Niveau, Eleonora Sosa Cuevas, Benoit Roubinet, Mylene Pezet, Michel Thepaut, Stephane Mouret, Julie Charles, Franck Fieschi, Ludovic Landemarre, Laurence Chaperot, Philippe Saas, Caroline Aspord

Summary: Dendritic cell subsets play a crucial role in shaping anti-tumour immunity. The study found that melanoma tumour cells display aberrant glycan motifs which can be sensed by dendritic cells through specific receptors. This interaction may lead to abnormal immune responses. The study suggests that targeting the glycan/receptor axis could be a promising strategy for improving cancer immunotherapy.

IMMUNOLOGY (2023)

添加到收藏夹

Article Critical Care Medicine

Plasma citrulline concentration and plasma LPS detection among critically ill patients a prospective observational study

Claire Chaignat, Laurent Lagrost, Karena Moretto, Jean-Paul Pais de Barros, Hadrien Winiszewski, Jacques Grober, Philippe Saas, Gael Piton

Summary: The aim of this study was to investigate the correlation between plasma citrulline levels and plasma lipopolysaccharide (LPS) concentration, as well as the impact of sepsis on gut function in critically ill patients. The results showed no correlation between plasma citrulline concentration and plasma LPS concentration or activity. However, septic patients had significantly lower plasma citrulline levels. Additionally, abdominal sepsis was associated with higher plasma LPS activity compared to extra-abdominal sepsis.

JOURNAL OF CRITICAL CARE (2024)

添加到收藏夹

暂无数据

© Peeref 2019-2024. All rights reserved.