Retina pathology as a target for biomarkers for Alzheimer's disease: Current status, ophthalmopathological background, challenges, and future directions

Retinal pathological features and proteome signatures of Alzheimer’s disease

(2023) Yosef Koronyo et al.   ACTA NEUROPATHOLOGICA

Levels of Alzheimer's disease blood biomarkers are altered after food intake—A pilot intervention study in healthy adults

(2023) Hanna Huber et al.   Alzheimers & Dementia

Retinal arterial Aβ40 deposition is linked with tight junction loss and cerebral amyloid angiopathy in MCI and AD patients

(2023) Haoshen Shi et al.   Alzheimers & Dementia

Retinotopic degeneration of the retina and optic tracts in autosomal dominant Alzheimer's disease

(2023) Suman Adhikari et al.   Alzheimers & Dementia

Disruption of early visual processing in amyloid-positive healthy individuals and mild cognitive impairment

(2023) Daniel C. Javitt et al.   Alzheimers Research & Therapy

Retinal fingerprints of ALS in patients: Ganglion cell apoptosis and TDP-43/p62 misplacement

(2023) Natalia Pediconi et al.   Frontiers in Aging Neuroscience

Primary retinal tauopathy: A tauopathy with a distinct molecular pattern

(2023) Grzegorz Walkiewicz et al.   Alzheimers & Dementia

Donanemab in Early Symptomatic Alzheimer Disease

(2023) John R. Sims et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Regulating microglial miR-155 transcriptional phenotype alleviates Alzheimer’s-induced retinal vasculopathy by limiting Clec7a/Galectin-3+ neurodegenerative microglia

(2022) Haoshen Shi et al.   Acta Neuropathologica Communications

Müller cell degeneration and microglial dysfunction in the Alzheimer’s retina

(2022) Qinyuan Alis Xu et al.   Acta Neuropathologica Communications

Phosphorylated tau in the retina correlates with tau pathology in the brain in Alzheimer’s disease and primary tauopathies

(2022) Frederique J. Hart de Ruyter et al.   ACTA NEUROPATHOLOGICA

Maturation of neuronal AD-tau pathology involves site-specific phosphorylation of cytoplasmic and synaptic tau preceding conformational change and fibril formation

(2021) Luis Aragão Gomes et al.   ACTA NEUROPATHOLOGICA

Past, present and future role of retinal imaging in neurodegenerative disease

(2021) Amir H. Kashani et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Sequence of proteome profiles in preclinical and symptomatic Alzheimer's disease

(2021) Xiaohang Li et al.   Alzheimers & Dementia

Association of Retinal Changes With Alzheimer Disease Neuroimaging Biomarkers in Cognitively Normal Individuals

(2021) Min Soo Byun et al.   JAMA Ophthalmology

Aducanumab: a new phase in therapeutic development for Alzheimer’s disease?

(2021) Giovanna Lalli et al.   EMBO Molecular Medicine

Retinal Amyloid Imaging for Screening Alzheimer’s Disease

(2021) Koh Tadokoro et al.   JOURNAL OF ALZHEIMERS DISEASE

Plasma phosphorylated tau 217 and phosphorylated tau 181 as biomarkers in Alzheimer's disease and frontotemporal lobar degeneration: a retrospective diagnostic performance study

(2021) Elisabeth H Thijssen et al.   LANCET NEUROLOGY

Standardisation of Optical Coherence Tomography Angiography Imaging Biomarkers in Diabetic Retinal Disease

(2021) Stela Vujosevic et al.   OPHTHALMIC RESEARCH

Retinal Vasculopathy in Alzheimer’s Disease

(2021) Haoshen Shi et al.   Frontiers in Neuroscience

Brain and Retinal Abnormalities in the 5xFAD Mouse Model of Alzheimer's Disease at Early Stages

(2021) Mengrong Zhang et al.   Frontiers in Neuroscience

ARCAM-1 Facilitates Fluorescence Detection of Amyloid-Containing Deposits in the Retina

(2021) Kevin J. Cao et al.   Translational Vision Science & Technology

Using the Alzheimer's Disease Neuroimaging Initiative to improve early detection, diagnosis, and treatment of Alzheimer's disease

(2021) Dallas P. Veitch et al.   Alzheimers & Dementia

Retinal Venular Tortuosity Jointly with Retinal Amyloid Burden Correlates with Verbal Memory Loss: A Pilot Study

(2021) Oana M. Dumitrascu et al.   Cells

Identification of early pericyte loss and vascular amyloidosis in Alzheimer’s disease retina

(2020) Haoshen Shi et al.   ACTA NEUROPATHOLOGICA

Developing retinal biomarkers for the earliest stages of Alzheimer's disease: What we know, what we don't, and how to move forward

(2020) Jessica Alber et al.   Alzheimers & Dementia

Large-scale proteomic analysis of Alzheimer’s disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation

(2020) Erik C. B. Johnson et al.   NATURE MEDICINE

Retinal nerve fiber layer thickness predicts CSF amyloid/tau before cognitive decline

(2020) Samuel Asanad et al.   PLoS One

Blood plasma phosphorylated-tau isoforms track CNS change in Alzheimer’s disease

(2020) Nicolas R. Barthélemy et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Amyloid Beta Immunoreactivity in the Retinal Ganglion Cell Layer of the Alzheimer’s Eye

(2020) Sieun Lee et al.   Frontiers in Neuroscience

Parallels between retinal and brain pathology and response to immunotherapy in old, late‐stage Alzheimer's disease mouse models

(2020) Jonah Doustar et al.   AGING CELL

Retinal imaging in Alzheimer's and neurodegenerative diseases

(2020) Peter J. Snyder et al.   Alzheimers & Dementia

Predicting Thioflavin Fluorescence of Retinal Amyloid Deposits Associated With Alzheimer's Disease from Their Polarimetric Properties

(2020) Yunyi Qiu et al.   Translational Vision Science & Technology

Convolutional neural network to identify symptomatic Alzheimer’s disease using multimodal retinal imaging

(2020) C. Ellis Wisely et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Retinal capillary degeneration and blood-retinal barrier disruption in murine models of Alzheimer’s disease

(2020) Haoshen Shi et al.   Acta Neuropathologica Communications

Deep and Frequent Phenotyping study protocol: an observational study in prodromal Alzheimer’s disease

(2019) Ivan Koychev et al.   BMJ Open

Retinal α-synuclein deposits in Parkinson’s disease patients and animal models

(2019) Lien Veys et al.   ACTA NEUROPATHOLOGICA

Changes in visual function and retinal structure in the progression of Alzheimer's disease

(2019) Elena Salobrar-García et al.   PLoS One

Neuroinflammatory Processes, A1 Astrocyte Activation and Protein Aggregation in the Retina of Alzheimer’s Disease Patients, Possible Biomarkers for Early Diagnosis

(2019) Alfonso Grimaldi et al.   Frontiers in Neuroscience

In Vivo Assessment of Retinal Biomarkers by Hyperspectral Imaging: Early Detection of Alzheimer’s Disease

(2019) Swati S. More et al.   ACS Chemical Neuroscience

Non-invasive in vivo hyperspectral imaging of the retina for potential biomarker use in Alzheimer’s disease

(2019) Xavier Hadoux et al.   Nature Communications

Levels of Retinal Amyloid-β Correlate with Levels of Retinal IAPP and Hippocampal Amyloid-β in Neuropathologically Evaluated Individuals

(2019) Nina Schultz et al.   JOURNAL OF ALZHEIMERS DISEASE

NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease

(2018) Clifford R. Jack et al.   Alzheimers & Dementia

Inflammation, neurodegeneration and protein aggregation in the retina as ocular biomarkers for Alzheimer’s disease in the 3xTg-AD mouse model

(2018) Alfonso Grimaldi et al.   Cell Death & Disease

The European Eye Epidemiology spectral-domain optical coherence tomography classification of macular diseases for epidemiological studies

(2018) Sarra Gattoussi et al.   ACTA OPHTHALMOLOGICA

Multisite study of the relationships between antemortem [11C]PIB-PET Centiloid values and postmortem measures of Alzheimer's disease neuropathology

(2018) Renaud La Joie et al.   Alzheimers & Dementia

The clinical relevance of visualising the peripheral retina

(2018) Nicola Quinn et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Association of Preclinical Alzheimer Disease With Optical Coherence Tomographic Angiography Findings

(2018) Bliss Elizabeth O’Bryhim et al.   JAMA Ophthalmology

Amyloid-beta and phosphorylated tau in post-mortem Alzheimer’s disease retinas

(2018) Jurre den Haan et al.   Acta Neuropathologica Communications

Tau accumulation in the retina promotes early neuronal dysfunction and precedes brain pathology in a mouse model of Alzheimer’s disease

(2017) Marius Chiasseu et al.   Molecular Neurodegeneration

Retinal vascular and structural changes are associated with amyloid burden in the elderly: ophthalmic biomarkers of preclinical Alzheimer’s disease

(2017) S.Mojtaba Golzan et al.   Alzheimers Research & Therapy

Optical Coherence Tomography in Alzheimer’s Disease and Other Neurodegenerative Diseases

(2017) Jonah Doustar et al.   Frontiers in Neurology

Ocular indicators of Alzheimer’s: exploring disease in the retina

(2016) Nadav J. Hart et al.   ACTA NEUROPATHOLOGICA

Tau Oligomers Associate with Inflammation in the Brain and Retina of Tauopathy Mice and in Neurodegenerative Diseases

(2016) Ashley N. Nilson et al.   JOURNAL OF ALZHEIMERS DISEASE

Reconnecting Eye to Brain

(2016) Michael C. Crair et al.   JOURNAL OF NEUROSCIENCE

Retinal amyloid peptides and complement factor H in transgenic models of Alzheimerʼs disease

(2016) Peter N. Alexandrov et al.   NEUROREPORT

Melanopsin retinal ganglion cell loss in Alzheimer disease

(2015) Chiara La Morgia et al.   ANNALS OF NEUROLOGY

Progression of Seed-Induced Aβ Deposition within the Limbic Connectome

(2015) Lan Ye et al.   BRAIN PATHOLOGY

Evidence for accelerated tauopathy in the retina of transgenic P301S tau mice exposed to repetitive mild traumatic brain injury

(2015) Leyan Xu et al.   EXPERIMENTAL NEUROLOGY

Spreading of pathology in neurodegenerative diseases: a focus on human studies

(2015) Johannes Brettschneider et al.   NATURE REVIEWS NEUROSCIENCE

Optical Coherence Tomography in Alzheimer’s Disease: A Meta-Analysis

(2015) Gianluca Coppola et al.   PLoS One

Visual function and retinal nerve fibre layer degeneration in patients with Alzheimer disease: correlations with severity of dementia

(2014) Maria P. Bambo et al.   ACTA OPHTHALMOLOGICA

Retinal fluorescence lifetime imaging ophthalmoscopy measures depend on the severity of Alzheimer's disease

(2014) Susanne Jentsch et al.   ACTA OPHTHALMOLOGICA

Connecting the Retina to the Brain

(2014) Lynda Erskine et al.   ASN Neuro

Biochemical stages of amyloid-β peptide aggregation and accumulation in the human brain and their association with symptomatic and pathologically preclinical Alzheimer’s disease

(2014) Ajeet Rijal Upadhaya et al.   BRAIN

Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD

(2014) Michael E. Ward et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Retinal alterations in mild cognitive impairment and Alzheimer’s disease: an optical coherence tomography study

(2014) Francisco J. Ascaso et al.   JOURNAL OF NEUROLOGY

Phosphorylated α-synuclein-immunoreactive retinal neuronal elements in Parkinson's disease subjects

(2014) Thomas G. Beach et al.   NEUROSCIENCE LETTERS

Prevalence of mixed pathologies in the aging brain

(2014) Jasmin Rahimi et al.   Alzheimers Research & Therapy

Detection of Retinal Nerve Fiber Layer Defects in Alzheimer’s Disease Using SD-OCT

(2014) Robert Kromer et al.   Frontiers in Psychiatry

Beta-Amyloid, Phospho-Tau and Alpha-Synuclein Deposits Similar to Those in the Brain Are Not Identified in the Eyes of Alzheimer's and Parkinson's Disease Patients

(2013) Cheng-Ying Ho et al.   BRAIN PATHOLOGY

Biomarker Modeling of Alzheimer’s Disease

(2013) Clifford R. Jack et al.   NEURON

Long-Term In Vivo Imaging of Fibrillar Tau in the Retina of P301S Transgenic Mice

(2013) Christian Schön et al.   PLoS One

Retinal Nerve Fiber Layer Thickness in Patients With Alzheimer Disease

(2012) Serkan Kirbas et al.   JOURNAL OF NEURO-OPHTHALMOLOGY

The OSCAR-IB Consensus Criteria for Retinal OCT Quality Assessment

(2012) Prejaas Tewarie et al.   PLoS One

Alzheimer’s pathogenesis: is there neuron-to-neuron propagation?

(2011) Heiko Braak et al.   ACTA NEUROPATHOLOGICA

High-molecular weight Aβ oligomers and protofibrils are the predominant Aβ species in the native soluble protein fraction of the AD brain

(2011) Ajeet Rijal Upadhaya et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years

(2011) Heiko Braak et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Identification of amyloid plaques in retinas from Alzheimer's patients and noninvasive in vivo optical imaging of retinal plaques in a mouse model

(2010) Maya Koronyo-Hamaoui et al.   NEUROIMAGE

Amyloid-Peptide Vaccinations Reduce β-Amyloid Plaques but Exacerbate Vascular Deposition and Inflammation in the Retina of Alzheimer’s Transgenic Mice

(2009) Bingqian Liu et al.   AMERICAN JOURNAL OF PATHOLOGY

Color Discrimination Performance in Patients with Alzheimer’s Disease

(2009) Giovanna Salamone et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Inter-laboratory comparison of neuropathological assessments of β-amyloid protein: a study of the BrainNet Europe consortium

(2008) Irina Alafuzoff et al.   ACTA NEUROPATHOLOGICA

Retinal tau pathology in human glaucomas

(2008) Neeru Gupta et al.   CANADIAN JOURNAL OF OPHTHALMOLOGY-JOURNAL CANADIEN D OPHTALMOLOGIE

Parenchymal and vascular Aβ-deposition and its effects on the degeneration of neurons and cognition in Alzheimer's disease

(2008) Dietmar Rudolf Thal et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE