Targeting VEGF with LNA-stabilized G-rich oligonucleotide for efficient breast cancer inhibition

Antisense oligonucleotides: modifications and clinical trials

(2014) Vivek K. Sharma et al.   MedChemComm

First-in-human Phase I study of EZN-4176, a locked nucleic acid antisense oligonucleotide to exon 4 of the androgen receptor mRNA in patients with castration-resistant prostate cancer

(2013) D Bianchini et al.   BRITISH JOURNAL OF CANCER

G-rich VEGF aptamer with locked and unlocked nucleic acid modifications exhibits a unique G-quadruplex fold

(2013) Maja Marušič et al.   NUCLEIC ACIDS RESEARCH

Efficient Reverse Transcription Using Locked Nucleic Acid Nucleotides towards the Evolution of Nuclease Resistant RNA Aptamers

(2012) Lucile Crouzier et al.   PLoS One

Thermodynamic and structural description of allosterically regulated VEGFR-2 dimerization

(2011) M. S. Brozzo et al.   BLOOD

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Locked vs. unlocked nucleic acids (LNA vs. UNA): contrasting structures work towards common therapeutic goals

(2011) Meghan A. Campbell et al.   CHEMICAL SOCIETY REVIEWS

Locked Nucleic Acids: Promising Nucleic Acid Analogs for Therapeutic Applications

(2010) Rakesh N. Veedu et al.   CHEMISTRY & BIODIVERSITY

Screening and Improvement of an Anti-VEGF DNA Aptamer

(2010) Yoshihiko Nonaka et al.   MOLECULES

Aptamers as therapeutics

(2010) Anthony D. Keefe et al.   NATURE REVIEWS DRUG DISCOVERY

Structural determinants of growth factor binding and specificity by VEGF receptor 2

(2010) V.-M. Leppanen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Locked nucleic acid as a novel class of therapeutic agents

(2010) Rakesh N. Veedu et al.   RNA Biology

Locked nucleic acid nucleoside triphosphates and polymerases: on the way towards evolution of LNA aptamers

(2009) Rakesh N. Veedu et al.   Molecular BioSystems

Bevacizumab

(2008) Paul L McCormack et al.   DRUGS

Polymerase Chain Reaction and Transcription Using Locked Nucleic Acid Nucleotide Triphosphates

(2008) Rakesh N. Veedu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY