Isoproterenol induces MD2 activation by β-AR-cAMP-PKA-ROS signalling axis in cardiomyocytes and macrophages drives inflammatory heart failure

Redox Activation of Mitochondrial DAMPs and the Metabolic Consequences for Development of Autoimmunity

(2022) Andreas Koenig et al.   ANTIOXIDANTS & REDOX SIGNALING

Toll‐like receptor‐2 in cardiomyocytes and macrophages mediates isoproterenol‐induced cardiac inflammation and remodeling

(2022) Jinfu Qian et al.   FASEB JOURNAL

Glibenclamide alleviates β adrenergic receptor activation-induced cardiac inflammation

(2021) Ning Cao et al.   ACTA PHARMACOLOGICA SINICA

Immune cell β2-adrenergic receptors contribute to the development of heart failure

(2021) Miles A. Tanner et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Prognostic Value of Elevated Levels of Plasma N-Acetylneuraminic Acid in Patients With Heart Failure

(2021) Chenze Li et al.   Circulation-Heart Failure

Macrophage-derived myeloid differentiation protein 2 plays an essential role in ox-LDL-induced inflammation and atherosclerosis

(2020) Taiwei Chen et al.   EBioMedicine

Cardiac Overexpression of PDE4B Blunts β-Adrenergic Response and Maladaptive Remodeling in Heart Failure

(2020) Sarah Karam et al.   CIRCULATION

Celastrol Attenuates Angiotensin II–Induced Cardiac Remodeling by Targeting STAT3

(2020) Shiju Ye et al.   CIRCULATION RESEARCH

MD2 activation by direct AGE interaction drives inflammatory diabetic cardiomyopathy

(2020) Yi Wang et al.   Nature Communications

Targeting Inflammation Driven by HMGB1

(2020) Huan Yang et al.   Frontiers in Immunology

Gentianella acuta prevents acute myocardial infarction induced by isoproterenol in rats via inhibition of galectin-3/TLR4/MyD88/NF-кB inflammatory signalling

(2020) Jia-Huan Sun et al.   INFLAMMOPHARMACOLOGY

Role of IgE-FcεR1 in Pathological Cardiac Remodeling and Dysfunction

(2020) Hongmei Zhao et al.   CIRCULATION

Nootkatone attenuates myocardial oxidative damage, inflammation, and apoptosis in isoproterenol-induced myocardial infarction in rats

(2020) M.F. Nagoor Meeran et al.   PHYTOMEDICINE

Heart Disease and Stroke Statistics—2019 Update: A Report From the American Heart Association

(2019) Emelia J. Benjamin et al.   CIRCULATION

Pathological cardiac hypertrophy: the synergy of adenylyl cyclases inhibition in cardiac and immune cells during chronic catecholamine stress

(2019) Gabriel Komla Adzika et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Unveiling the Interplay between the TLR4/MD2 Complex and HSP70 in the Human Cardiovascular System: A Computational Approach

(2019) Amanda Almeida de Oliveira et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effects of carvedilol vs bisoprolol on inflammation and oxidative stress in patients with chronic heart failure

(2019) Shigeru Toyoda et al.   Journal of Cardiology

Gal-3 (Galectin-3) and K Ca 3.1 Mediate Heterogeneous Cell Coupling and Myocardial Fibrogenesis Driven by βAR (β-Adrenoceptor) Activation

(2019) Gang She et al.   HYPERTENSION

MD-2 is a new predictive biomarker in dilated cardiomyopathy and exerts direct effects in isolated cardiomyocytes

(2018) Alexander Riad et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Myeloid differentiation protein 2 induced retinal ischemia reperfusion injury via upregulation of ROS through a TLR4-NOX4 pathway

(2018) Huaicheng Chen et al.   TOXICOLOGY LETTERS

Author Correction: Saturated palmitic acid induces myocardial inflammatory injuries through direct binding to TLR4 accessory protein MD2

(2018) Yi Wang et al.   Nature Communications

IL-18 cleavage triggers cardiac inflammation and fibrosis upon β-adrenergic insult

(2017) Han Xiao et al.   EUROPEAN HEART JOURNAL

Induction of cardiac dysfunction in developing and adult zebrafish by chronic isoproterenol stimulation

(2017) Mandy Kossack et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

MD2 mediates angiotensin II-induced cardiac inflammation and remodeling via directly binding to Ang II and activating TLR4/NF-κB signaling pathway

(2016) Jibo Han et al.   BASIC RESEARCH IN CARDIOLOGY

Regulation of cellular oxidative stress and apoptosis by G protein-coupled receptor kinase-2; The role of NADPH oxidase 4

(2016) Tiju Theccanat et al.   CELLULAR SIGNALLING

MD-2 as the target of a novel small molecule, L6H21, in the attenuation of LPS-induced inflammatory response and sepsis

(2015) Yi Wang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Immune Cell and Other Noncardiomyocyte Regulation of Cardiac Hypertrophy and Remodeling

(2015) R. A. Frieler et al.   CIRCULATION

Effects of ROS-relative NF-κB signaling on high glucose-induced TLR4 and MCP-1 expression in podocyte injury

(2015) Miaomiao Wei et al.   MOLECULAR IMMUNOLOGY

Adrenergic regulation of innate immunity: a review

(2015) Angela Scanzano et al.   Frontiers in Pharmacology

Adrenergic signaling and oxidative stress: a role for sirtuins?

(2013) Graziamaria Corbi et al.   Frontiers in Physiology

β-Adrenergic receptor subtype signaling in heart: From bench to bedside

(2012) Anthony Yiu Ho Woo et al.   ACTA PHARMACOLOGICA SINICA

Myeloid differentiation 2 as a therapeutic target of inflammatory disorders

(2011) Sun Hong Park et al.   PHARMACOLOGY & THERAPEUTICS

Beta2-adrenergic receptor regulates cardiac fibroblast autophagy and collagen degradation

(2010) Pablo Aránguiz-Urroz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Myocardial oxidative stress contributes to transgenic β2-adrenoceptor activation-induced cardiomyopathy and heart failure

(2010) Q Xu et al.   BRITISH JOURNAL OF PHARMACOLOGY

A new regulation of IL-6 production in adult cardiomyocytes by β-adrenergic and IL-1β receptors and induction of cellular hypertrophy by IL-6 trans-signalling

(2010) Nicolas Szabo-Fresnais et al.   CELLULAR SIGNALLING

β-Adrenergic stimulation and myocardial function in the failing heart

(2009) Ali El-Armouche et al.   HEART FAILURE REVIEWS

Cardiac fibroblasts: At the heart of myocardial remodeling

(2009) Karen E. Porter et al.   PHARMACOLOGY & THERAPEUTICS

Elevated cyclic AMP and PDE4 inhibition induce chemokine expression in human monocyte-derived macrophages

(2009) A. L. Hertz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High Glucose Induces Toll-Like Receptor Expression in Human Monocytes: Mechanism of Activation

(2008) M. R. Dasu et al.   DIABETES