Redox Activation of Mitochondrial DAMPs and the Metabolic Consequences for Development of Autoimmunity

Mechanisms and regulation of protein synthesis in mitochondria

(2021) Eva Kummer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Neutrophil and Eosinophil DNA Extracellular Trap Formation: Lessons From Pathogenic Fungi

(2021) Juliana da Costa Silva et al.   Frontiers in Microbiology

The Release Kinetics of Eosinophil Peroxidase and Mitochondrial DNA Is Different in Association with Eosinophil Extracellular Trap Formation

(2021) Nina Germic et al.   Cells

Mitochondrial Oxidative Stress and “Mito-Inflammation”: Actors in the Diseases

(2021) Simone Patergnani et al.   Biomedicines

Role of Mitochondria-Derived Danger Signals Released after Injury in Systemic Inflammation and Sepsis

(2021) Kiyoshi Itagaki et al.   ANTIOXIDANTS & REDOX SIGNALING

Stress and circulating cell-free mitochondrial DNA: a systematic review of human studies, physiological considerations, and technical recommendations

(2021) Caroline Trumpff et al.   MITOCHONDRION

Cytoplasmic condensation induced by membrane damage is associated with antibiotic lethality

(2021) Felix Wong et al.   Nature Communications

Biomarkers of nucleic acid oxidation – A summary state-of-the-art

(2021) Mu-Rong Chao et al.   Redox Biology

Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

(2020) Helmut Sies et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Evolutionary Ecology and Interplay of Prokaryotic Innate and Adaptive Immune Systems

(2020) Tatiana Dimitriu et al.   CURRENT BIOLOGY

Hydrogen peroxide diffusion and scavenging shapes mitochondrial network instability and failure by sensitizing ROS-induced ROS release

(2020) Brent Millare et al.   Scientific Reports

Reactive oxygen species oxidize STING and suppress interferon production

(2020) Lili Tao et al.   eLife

Production of superoxide and hydrogen peroxide in the mitochondrial matrix is dominated by site IQ of complex I in diverse cell lines

(2020) Jingqi Fang et al.   Redox Biology

Dynamic Cardiolipin Synthesis Is Required for CD8+ T Cell Immunity

(2020) Mauro Corrado et al.   Cell Metabolism

Mitochondrial dysfunction in sepsis is associated with diminished intramitochondrial TFAM despite its increased cellular expression

(2020) Tim Rahmel et al.   Scientific Reports

RNA Modifications Modulate Activation of Innate Toll-Like Receptors

(2019) Isabel Freund et al.   Genes

Mitochondrial reactive oxygen species enable proinflammatory signaling through disulfide linkage of NEMO

(2019) Marc Herb et al.   Science Signaling

Transcription, Processing, and Decay of Mitochondrial RNA in Health and Disease

(2019) Arianna Barchiesi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Interleukin-1β Induces mtDNA Release to Activate Innate Immune Signaling via cGAS-STING

(2019) Lauren D. Aarreberg et al.   MOLECULAR CELL

Constitutive release of CPS1 in bile and its role as a protective cytokine during acute liver injury

(2019) Min-Jung Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circulating Cell-Free mtDNA Contributes to AIM2 Inflammasome-Mediated Chronic Inflammation in Patients with Type 2 Diabetes

(2019) Jung Hwan Bae et al.   Cells

Aconitases: Non-redox Iron–Sulfur Proteins Sensitive to Reactive Species

(2019) Laura Castro et al.   ACCOUNTS OF CHEMICAL RESEARCH

Eosinophil extracellular trap formation is closely associated with disease severity in chronic rhinosinusitis regardless of nasal polyp status

(2019) Chi Sang Hwang et al.   Scientific Reports

Defects of mitochondrial RNA turnover lead to the accumulation of double-stranded RNA in vivo

(2019) Aleksandra Pajak et al.   PLoS Genetics

Catalysis of Peroxide Reduction by Fast Reacting Protein Thiols

(2019) Ari Zeida et al.   CHEMICAL REVIEWS

Citrulline production and protein homeostasis

(2019) Antonin Ginguay et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Human mitochondrial DNA is extensively methylated in a non-CpG context

(2019) Vibha Patil et al.   NUCLEIC ACIDS RESEARCH

New moonlighting functions of mitochondrial cytochrome c in the cytoplasm and nucleus

(2019) Katiuska González‐Arzola et al.   FEBS LETTERS

Innate immunity as the trigger of systemic autoimmune diseases

(2019) Victoria Saferding et al.   JOURNAL OF AUTOIMMUNITY

Biological Production, Detection, and Fate of Hydrogen Peroxide

(2018) Christine C. Winterbourn   ANTIOXIDANTS & REDOX SIGNALING

Mechanisms of TFAM-mediated cardiomyocyte protection

(2018) George H. Kunkel et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Infection with the dengue RNA virus activates TLR9 signaling in human dendritic cells

(2018) Jenn‐Haung Lai et al.   EMBO REPORTS

Acetylation and phosphorylation of human TFAM regulate TFAM–DNA interactions via contrasting mechanisms

(2018) Graeme A King et al.   NUCLEIC ACIDS RESEARCH

Activation of intestinal tuft cell-expressed Sucnr1 triggers type 2 immunity in the mouse small intestine

(2018) Weiwei Lei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modified nucleoside triphosphates exist in mammals

(2018) Han-Peng Jiang et al.   Chemical Science

Mitochondrial Damage-Associated Molecular Patterns: From Inflammatory Signaling to Human Diseases

(2018) Serge Grazioli et al.   Frontiers in Immunology

Krebs Cycle Reimagined: The Emerging Roles of Succinate and Itaconate as Signal Transducers

(2018) Michael P. Murphy et al.   CELL

Membrane potential and delta pH dependency of reverse electron transport-associated hydrogen peroxide production in brain and heart mitochondria

(2018) Tímea Komlódi et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

PKR Senses Nuclear and Mitochondrial Signals by Interacting with Endogenous Double-Stranded RNAs

(2018) Yoosik Kim et al.   MOLECULAR CELL

Mitochondrial double-stranded RNA triggers antiviral signalling in humans

(2018) Ashish Dhir et al.   NATURE

Neutrophil extracellular trap formation requires OPA1-dependent glycolytic ATP production

(2018) Poorya Amini et al.   Nature Communications

A CD4+ T cell population expanded in lupus blood provides B cell help through interleukin-10 and succinate

(2018) Simone Caielli et al.   NATURE MEDICINE

Reactive Oxygen Species–Producing Myeloid Cells Act as a Bone Marrow Niche for Sterile Inflammation–Induced Reactive Granulopoiesis

(2017) Haiyan Zhu et al.   JOURNAL OF IMMUNOLOGY

Spontaneous activation of a MAVS-dependent antiviral signaling pathway determines high basal interferon-β expression in cardiac myocytes

(2017) Efraín E. Rivera-Serrano et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Mechanisms of Cellular Activation in the Antiphospholipid Syndrome

(2017) Nadine Müller-Calleja et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

mGluR2/3 activation of the SIRT1 axis preserves mitochondrial function in diabetic neuropathy

(2017) Krish Chandrasekaran et al.   Annals of Clinical and Translational Neurology

Dengue virus NS2B protein targets cGAS for degradation and prevents mitochondrial DNA sensing during infection

(2017) Sebastian Aguirre et al.   Nature Microbiology

Dengue virus activates cGAS through the release of mitochondrial DNA

(2017) Bo Sun et al.   Scientific Reports

Peroxynitrite: From interception to signaling

(2016) Bodo Speckmann et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation

(2016) Vicky Lampropoulou et al.   Cell Metabolism

Mitochondrial generation of superoxide and hydrogen peroxide as the source of mitochondrial redox signaling

(2016) Martin D. Brand   FREE RADICAL BIOLOGY AND MEDICINE

Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels

(2016) Thekla Cordes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9

(2016) Irma Garcia-Martinez et al.   JOURNAL OF CLINICAL INVESTIGATION

GPR91 senses extracellular succinate released from inflammatory macrophages and exacerbates rheumatoid arthritis

(2016) Amanda Littlewood-Evans et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Oxidized mitochondrial nucleoids released by neutrophils drive type I interferon production in human lupus

(2016) Simone Caielli et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease

(2016) Christian Lood et al.   NATURE MEDICINE

Intracellular innate immune surveillance devices in plants and animals

(2016) J. D. G. Jones et al.   SCIENCE

Fosfomycin enhances phagocyte-mediated killing of Staphylococcus aureus by extracellular traps and reactive oxygen species

(2016) Fengge Shen et al.   Scientific Reports

Prion-like Aggregation of Mitochondrial Antiviral Signaling Protein in Lupus Patients Is Associated With Increased Levels of Type I Interferon

(2016) Wen-Hai Shao et al.   Arthritis & Rheumatology

Hydrogen Sulfide Maintains Mitochondrial DNA Replication via Demethylation of TFAM

(2015) Shuangshuang Li et al.   ANTIOXIDANTS & REDOX SIGNALING

Selective superoxide generation within mitochondria by the targeted redox cycler MitoParaquat

(2015) Ellen L. Robb et al.   FREE RADICAL BIOLOGY AND MEDICINE

Control of adaptive immunity by the innate immune system

(2015) Akiko Iwasaki et al.   NATURE IMMUNOLOGY

Dichotomous roles for externalized cardiolipin in extracellular signaling: Promotion of phagocytosis and attenuation of innate immunity

(2015) Krishnakumar Balasubramanian et al.   Science Signaling

Dichotomous roles for externalized cardiolipin in extracellular signaling: Promotion of phagocytosis and attenuation of innate immunity

(2015) Krishnakumar Balasubramanian et al.   Science Signaling

Carbamoyl phosphate synthetase-1 is a rapid turnover biomarker in mouse and human acute liver injury

(2014) Sujith V. W. Weerasinghe et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Mitochondrially localized ERK2 regulates mitophagy and autophagic cell stress

(2014) Ruben K. Dagda et al.   Autophagy

Apoptotic Caspases Suppress mtDNA-Induced STING-Mediated Type I IFN Production

(2014) Michael J. White et al.   CELL

Apoptotic Caspases Prevent the Induction of Type I Interferons by Mitochondrial DNA

(2014) Anthony Rongvaux et al.   CELL

Posttranslational modification of mitochondrial transcription factor A in impaired mitochondria biogenesis: Implications in diabetic retinopathy and metabolic memory phenomenon

(2014) Julia M. Santos et al.   EXPERIMENTAL EYE RESEARCH

Oxidative modification enhances the immunostimulatory effects of extracellular mitochondrial DNA on plasmacytoid dendritic cells

(2014) Kitti Pazmandi et al.   FREE RADICAL BIOLOGY AND MEDICINE

The dual role of innate immunity in antiphospholipid syndrome and systemic lupus erythematosus

(2014) D Salem et al.   LUPUS

ERK-mediated phosphorylation of TFAM downregulates mitochondrial transcription: Implications for Parkinson's disease

(2014) Kent Z.Q. Wang et al.   MITOCHONDRION

Mitochondrial transcription factor A (Tfam) is a pro-inflammatory extracellular signaling molecule recognized by brain microglia

(2014) Jonathan P. Little et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

A novel intermediate in transcription initiation by human mitochondrial RNA polymerase

(2014) Yaroslav I. Morozov et al.   NUCLEIC ACIDS RESEARCH

Mitochondrial Cardiolipin Is Required for Nlrp3 Inflammasome Activation

(2013) Shankar S. Iyer et al.   IMMUNITY

Oxidative Damage of DNA Confers Resistance to Cytosolic Nuclease TREX1 Degradation and Potentiates STING-Dependent Immune Sensing

(2013) Nadine Gehrke et al.   IMMUNITY

Elimination of Mitochondrial DNA Is Not Required for Herpes Simplex Virus 1 Replication

(2013) B. A. Duguay et al.   JOURNAL OF VIROLOGY

Regionally Specific and Genome-Wide Analyses Conclusively Demonstrate the Absence of CpG Methylation in Human Mitochondrial DNA

(2013) E. E. Hong et al.   MOLECULAR AND CELLULAR BIOLOGY

Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING

(2013) Xu Zhang et al.   MOLECULAR CELL

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity

(2013) John W. Schoggins et al.   NATURE

Mitochondrial Transcription Factor A, an Endogenous Danger Signal, Promotes TNFα Release via RAGE- and TLR9-Responsive Plasmacytoid Dendritic Cells

(2013) Mark W. Julian et al.   PLoS One

Succinate: a metabolic signal in inflammation

(2013) Evanna Mills et al.   TRENDS IN CELL BIOLOGY

Regulation of the cell cycle via mitochondrial gene expression and energy metabolism in HeLa cells

(2012) W. Xiong et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Mitochondrial Complex II Can Generate Reactive Oxygen Species at High Rates in Both the Forward and Reverse Reactions

(2012) Casey L. Quinlan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial redox signalling at a glance

(2012) Yvonne Collins et al.   JOURNAL OF CELL SCIENCE

Mitochondrial Transcription Factor A Serves as a Danger Signal by Augmenting Plasmacytoid Dendritic Cell Responses to DNA

(2012) M. W. Julian et al.   JOURNAL OF IMMUNOLOGY

Phosphorylation of Human TFAM in Mitochondria Impairs DNA Binding and Promotes Degradation by the AAA+ Lon Protease

(2012) Bin Lu et al.   MOLECULAR CELL

Human mitochondrial RNA decay mediated by PNPase–hSuv3 complex takes place in distinct foci

(2012) Lukasz S. Borowski et al.   NUCLEIC ACIDS RESEARCH

Critical role for calcium mobilization in activation of the NLRP3 inflammasome

(2012) T. Murakami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

From Sulfenylation to Sulfhydration: What a Thiolate Needs to Tolerate

(2012) T. Finkel   Science Signaling

The high mobility group box: the ultimate utility player of a cell

(2012) Christopher S. Malarkey et al.   TRENDS IN BIOCHEMICAL SCIENCES

Extracellular ATP mediates mast cell-dependent intestinal inflammation through P2X7 purinoceptors

(2012) Yosuke Kurashima et al.   Nature Communications

Redox State-Dependent Interaction of HMGB1 and Cisplatin-Modified DNA

(2011) Semi Park et al.   BIOCHEMISTRY

Unraveling the Biological Roles of Reactive Oxygen Species

(2011) Michael P. Murphy et al.   Cell Metabolism

A loss-of-function variant of the antiviral molecule MAVS is associated with a subset of systemic lupus patients

(2011) Julien Pothlichet et al.   EMBO Molecular Medicine

Crystal Structure of NALP3 Protein Pyrin Domain (PYD) and Its Implications in Inflammasome Assembly

(2011) Ju Young Bae et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Danger Signal, Extracellular ATP, Is a Sensor for an Airborne Allergen and Triggers IL-33 Release and Innate Th2-Type Responses

(2011) Hideaki Kouzaki et al.   JOURNAL OF IMMUNOLOGY

Super-resolution microscopy reveals that mammalian mitochondrial nucleoids have a uniform size and frequently contain a single copy of mtDNA

(2011) C. Kukat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Emerging role of damage-associated molecular patterns derived from mitochondria in inflammation

(2011) Dmitri V. Krysko et al.   TRENDS IN IMMUNOLOGY

Pattern Recognition Receptors and the Innate Immune Response to Viral Infection

(2011) Mikayla R. Thompson et al.   Viruses-Basel

High-Mobility Group Box 1, Oxidative Stress, and Disease

(2010) Daolin Tang et al.   ANTIOXIDANTS & REDOX SIGNALING

Reactive Oxygen Species Level Defines Two Functionally Distinctive Stages of Inflammatory Dendritic Cell Development from Mouse Bone Marrow

(2010) K.-C. Sheng et al.   JOURNAL OF IMMUNOLOGY

Programmed cell death triggered by nucleotide pool damage and its prevention by MutT homolog-1 (MTH1) with oxidized purine nucleoside triphosphatase

(2010) Yusaku Nakabeppu et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

Pannexin 1 channels mediate ‘find-me’ signal release and membrane permeability during apoptosis

(2010) Faraaz B. Chekeni et al.   NATURE

IFI16 is an innate immune sensor for intracellular DNA

(2010) Leonie Unterholzner et al.   NATURE IMMUNOLOGY

Dynamic regulation of cardiolipin by the lipid pump Atp8b1 determines the severity of lung injury in experimental pneumonia

(2010) Nancy B Ray et al.   NATURE MEDICINE

A Reaction-Diffusion Model of ROS-Induced ROS Release in a Mitochondrial Network

(2010) Lufang Zhou et al.   PLoS Computational Biology

Cytochrome c-induced lymphocyte death from the outside in: inhibition by serum leucine-rich alpha-2-glycoprotein-1

(2009) Ramil Codina et al.   APOPTOSIS

Human antiphospholipid antibodies induce TNFα in monocytes via Toll-like receptor 8

(2009) Yvonne Döring et al.   IMMUNOBIOLOGY

Herpes Simplex Virus UL12.5 Targets Mitochondria through a Mitochondrial Localization Sequence Proximal to the N Terminus

(2009) J. A. Corcoran et al.   JOURNAL OF VIROLOGY

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

(2009) Teresa Fernandes-Alnemri et al.   NATURE

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

(2009) Veit Hornung et al.   NATURE

Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

(2009) Michael R. Elliott et al.   NATURE

Oxygen Toxicity and Reactive Oxygen Species: The Devil Is in the Details

(2009) Richard L Auten et al.   PEDIATRIC RESEARCH

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Induction of Immunological Tolerance by Apoptotic Cells Requires Caspase-Dependent Oxidation of High-Mobility Group Box-1 Protein

(2008) Hirotaka Kazama et al.   IMMUNITY

Cytochrome c: a non-invasive biomarker of drug-induced liver injury

(2008) T. J. Miller et al.   JOURNAL OF APPLIED TOXICOLOGY

Glucose metabolism inhibits apoptosis in neurons and cancer cells by redox inactivation of cytochrome c

(2008) Allyson E. Vaughn et al.   NATURE CELL BIOLOGY

Triggering the succinate receptor GPR91 on dendritic cells enhances immunity

(2008) Tina Rubic et al.   NATURE IMMUNOLOGY