Globular adiponectin ameliorates insulin resistance in skeletal muscle by enhancing the LKB1-mediated AMPK activation via SESN2

Why does obesity cause diabetes?

(2022) Samuel Klein et al.   Cell Metabolism

The complex role of adipokines in obesity, inflammation, and autoimmunity

(2021) Erin B. Taylor   CLINICAL SCIENCE

Distribution patterns of intramyocellular and extramyocellular fat by magnetic resonance imaging in subjects with diabetes, prediabetes and normoglycaemic controls

(2021) Lena S. Kiefer et al.   DIABETES OBESITY & METABOLISM

AKT ISOFORMS-AS160-GLUT4: The defining axis of insulin resistance

(2021) Medha Sharma et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Different Effects of Leucine Supplementation and/or Exercise on Systemic Insulin Sensitivity in Mice

(2021) Xiaofan Jiang et al.   Frontiers in Endocrinology

Biglycan reduces body weight by regulating food intake in mice and improves glucose metabolism through AMPK/AKT dual pathways in skeletal muscle

(2021) InHyeok Chung et al.   FASEB JOURNAL

Exercise does not improve insulin resistance and mitochondrial characteristics together

(2021) Amanda J Genders et al.   JOURNAL OF ENDOCRINOLOGY

Globular Adiponectin Inhibits Breast Cancer Cell Growth through Modulation of Inflammasome Activation: Critical Role of Sestrin2 and AMPK Signaling

(2020) Duc-Vinh Pham et al.   Cancers

Prevalence of diabetes recorded in mainland China using 2018 diagnostic criteria from the American Diabetes Association: national cross sectional study

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Exercise adaptations: molecular mechanisms and potential targets for therapeutic benefit

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Mechanisms by which adiponectin reverses high fat diet-induced insulin resistance in mice

(2020) Xiruo Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SESTRINs: Emerging Dynamic Stress-Sensors in Metabolic and Environmental Health

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Mechanisms of Aerobic Exercise Upregulating the Expression of Hippocampal Synaptic Plasticity-Associated Proteins in Diabetic Rats

(2019) Jingjing Li et al.   NEURAL PLASTICITY

Adiponectin—Consideration for its Role in Skeletal Muscle Health

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Skeletal muscle adiponectin induction in obesity and exercise

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Sestrin2 prevents age-related intolerance to post myocardial infarction via AMPK/PGC-1α pathway

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Exercise improves glucose uptake in murine myotubes through the AMPKα2-mediated induction of Sestrins

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The PI3K/AKT pathway in obesity and type 2 diabetes

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Sestrin 2 induces autophagy and attenuates insulin resistance by regulating AMPK signaling in C2C12 myotubes

(2017) Huige Li et al.   EXPERIMENTAL CELL RESEARCH

Sestrin2 prevents age-related intolerance to ischemia and reperfusion injury by modulating substrate metabolism

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Lkb1 regulation of skeletal muscle development, metabolism and muscle progenitor cell homeostasis

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Improvement of obesity-linked skeletal muscle insulin resistance by strength and endurance training

(2017) Sergio Di Meo et al.   JOURNAL OF ENDOCRINOLOGY

Exercise restores muscle stem cell mobilization, regenerative capacity and muscle metabolic alterations via adiponectin/AdipoR1 activation in SAMP10 mice

(2016) Aiko Inoue et al.   Journal of Cachexia Sarcopenia and Muscle

Sestrin2 promotes LKB1-mediated AMPK activation in the ischemic heart

(2015) Alex Morrison et al.   FASEB JOURNAL

AMPK binds to Sestrins and mediates the effect of exercise to increase insulin-sensitivity through autophagy

(2015) Xiaolei Liu et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Deep Proteomics of Mouse Skeletal Muscle Enables Quantitation of Protein Isoforms, Metabolic Pathways, and Transcription Factors

(2015) Atul S. Deshmukh et al.   MOLECULAR & CELLULAR PROTEOMICS

Integrative Biology of Exercise

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Globular adiponectin induces LKB1/AMPK-dependent glucose uptake via actin cytoskeleton remodeling

(2013) Vivian Vu et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Exercise, GLUT4, and Skeletal Muscle Glucose Uptake

(2013) Erik A. Richter et al.   PHYSIOLOGICAL REVIEWS

Maintenance of Metabolic Homeostasis by Sestrin2 and Sestrin3

(2012) Jun Hee Lee et al.   Cell Metabolism

Exercise training performed simultaneously to a high-fat diet reduces the degree of insulin resistance and improves adipoR1-2/APPL1 protein levels in mice

(2012) JM Farias et al.   Lipids in Health and Disease

Adiponectin suppresses gluconeogenic gene expression in mouse hepatocytes independent of LKB1-AMPK signaling

(2011) Russell A. Miller et al.   JOURNAL OF CLINICAL INVESTIGATION

APPL1 Mediates Adiponectin-Induced LKB1 Cytosolic Localization Through the PP2A-PKCζ Signaling Pathway

(2011) Sathyaseelan S. Deepa et al.   MOLECULAR ENDOCRINOLOGY

Adiponectin and AdipoR1 regulate PGC-1α and mitochondria by Ca2+ and AMPK/SIRT1

(2010) Masato Iwabu et al.   NATURE

Diet-Induced Weight Loss and Exercise Alone and in Combination Enhance the Expression of Adiponectin Receptors in Adipose Tissue and Skeletal Muscle, but Only Diet-Induced Weight Loss Enhanced Circulating Adiponectin

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