Development of a Rapid Throughput Assay for Identification of hNav1.7 Antagonist Using Unique Efficacious Sodium Channel Agonist, Antillatoxin

The natural scorpion peptide, BmK NT1 activates voltage-gated sodium channels and produces neurotoxicity in primary cultured cerebellar granule cells

(2016) Xiaohan Zou et al.   TOXICON

Engineering Potent and Selective Analogues of GpTx-1, a Tarantula Venom Peptide Antagonist of the NaV1.7 Sodium Channel

(2015) Justin K. Murray et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Riluzole Derivative 2-Amino-6-trifluoromethylthio-benzothiazole (SKA-19), a Mixed KCa2 Activator and NaV Blocker, is a Potent Novel Anticonvulsant

(2014) Nichole Coleman et al.   Neurotherapeutics

High-throughput fluorescent-based NKCC functional assay in adherent epithelial cells

(2013) Monica Carmosino et al.   BMC CELL BIOLOGY

Properties of human brain sodium channel α-subunits expressed in HEK293 cells and their modulation by carbamazepine, phenytoin and lamotrigine

(2013) Xin Qiao et al.   BRITISH JOURNAL OF PHARMACOLOGY

Diphenytoin, riluzole and lidocaine: Three sodium channel blockers, with different mechanisms of action, decrease hippocampal epileptiform activity

(2013) Lihong Diao et al.   NEUROPHARMACOLOGY

Phenytoin Inhibits the Persistent Sodium Current in Neocortical Neurons by Modifying Its Inactivation Properties

(2013) Elisa Colombo et al.   PLoS One

In silico docking reveals possible Riluzole binding sites on Nav1.6 sodium channel: Implications for amyotrophic lateral sclerosis therapy

(2012) Omar Sierra Bello et al.   JOURNAL OF THEORETICAL BIOLOGY

Distinct Nav1.7-dependent pain sensations require different sets of sensory and sympathetic neurons

(2012) Michael S. Minett et al.   Nature Communications

Antillatoxin is a sodium channel activator that displays unique efficacy in heterologously expressed rNav1.2, rNav1.4 and rNav1.5 alpha subunits

(2011) Zhengyu Cao et al.   BMC NEUROSCIENCE

Lidocaine reduces the transition to slow inactivation in Nav1.7 voltage-gated sodium channels

(2011) Patrick L Sheets et al.   BRITISH JOURNAL OF PHARMACOLOGY

Additivity of Pyrethroid Actions on Sodium Influx in Cerebrocortical Neurons in Primary Culture

(2011) Zhengyu Cao et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Intra- and Interfamily Phenotypic Diversity in Pain Syndromes Associated with a Gain-of-Function Variant of NaV1.7

(2011) Mark Estación et al.   Molecular Pain

Identification of Human Ether-à-go-go Related Gene Modulators by Three Screening Platforms in an Academic Drug-Discovery Setting

(2010) Xi-Ping Huang et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

The Twisted Side Chain of Antillatoxin is Important for Potent Toxicity: Total Synthesis and Biological Evaluation of Antillatoxin and Analogues

(2009) Ken Okura et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A novel Nav1.7 mutation producing carbamazepine-responsive erythromelalgia

(2009) Tanya Z. Fischer et al.   ANNALS OF NEUROLOGY

Sodium Channel Inhibitor Drug Discovery Using Automated High Throughput Electrophysiology Platforms

(2009) Neil Castle et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

High-Throughput Screening Reveals a Small-Molecule Inhibitor of the Renal Outer Medullary Potassium Channel and Kir7.1

(2009) L. M. Lewis et al.   MOLECULAR PHARMACOLOGY

Human embryonic kidney (HEK293) cells express endogenous voltage-gated sodium currents and Nav1.7 sodium channels

(2009) Bingjun He et al.   NEUROSCIENCE LETTERS

Small-molecule screen identifies inhibitors of the neuronal K-Cl cotransporter KCC2

(2009) E. Delpire et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Influence of Lipid-Soluble Gating Modifier Toxins on Sodium Influx in Neocortical Neurons

(2008) Z. Cao et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

A Novel Assay of Gi/o-Linked G Protein-Coupled Receptor Coupling to Potassium Channels Provides New Insights into the Pharmacology of the Group III Metabotropic Glutamate Receptors

(2008) C. M. Niswender et al.   MOLECULAR PHARMACOLOGY

High-throughput electrophysiology: an emerging paradigm for ion-channel screening and physiology

(2008) John Dunlop et al.   NATURE REVIEWS DRUG DISCOVERY

Cellular HTS Assays for Pharmacological Characterization of NaV1.7 Modulators

(2007) Shephali Trivedi et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES