期刊
MACROMOLECULAR RAPID COMMUNICATIONS
卷 37, 期 19, 页码 1587-1592出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/marc.201600336
关键词
biodegradable polymers; drug delivery systems; poly(ethylene glycol); post-polymerization modification; ruthenium
资金
- Camille Dreyfus Teacher-Scholar Awards Program
- U.S. Army Research Office [W911NF-09-1-0446, W911NF-09-1-0456]
- National Science Foundation [CHE-1266323]
- IBS [IBS-R019-D1]
- BK21 Plus Program - Ministry of Education
- National Research Foundation of Korea
To enhance the limited degradability of poly(ethylene glycol) (PEG), a straightforward method of synthesizing poly[(ethylene glycol)-co-(glycolic acid)] (P(EG-co-GA)) via a ruthenium- catalyzed, post-polymerization oxyfunctionalization of various PEGs is developed. Using this method, a set of copolymers with GA compositions of up to 8 mol% are prepared with minimal reduction in molecular weight (<10%) when compared to their commercially available starting materials. The P(EG-co-GA) copolymers are shown to undergo hydrolysis under mild conditions.
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