期刊
MACROMOLECULAR BIOSCIENCE
卷 17, 期 4, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201600347
关键词
antibiotic delivery; anti-infective hydrogels; bacterial inhibition; injectable hydrogels; polysaccharide hydrogels
资金
- National Natural Science Foundation of China [51233004, 51390484, 21574127, 51622307]
Biocompatible and antibacterial hydrogels have received increasing attention for preventing local bacterial infections. In this study, a type of polysaccharide hydrogels is prepared via the Schiff-based reaction at physiological conditions. The gelation time and mechanical property of the hydrogels are found to be dependent on the polysaccharide concentration and the polysaccharide weight ratio. 3-(4,5-Dimethyl-thiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay and live/dead assay indicate that the hydrogels display nontoxicity in vitro. After subcutaneous injection into rats, the hydrogels exhibit an acceptable biocompatibility in vivo. Furthermore, the bacterial inhibition tests by shaking flask method and agar disc-diffusion method demonstrate that the ceftriaxone-sodiumloaded hydrogels have remarkable antibacterial properties in vitro. The in vivo anti-infective tests further display that the antibiotic-loaded hydrogels display excellent anti-infective efficacies in both superficial and deep tissue infection. Consequently, the injectable and biocompatible polysaccharide hydrogels may serve as promising platforms for localized, sustained delivery of antibiotics for preventing local infections.
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