Article
Nanoscience & Nanotechnology
Yuto Honda, Takahiro Nomoto, Makoto Matsui, Hiroyasu Takemoto, Yutaka Miura, Nobuhiro Nishiyama
Summary: The construction of a systemically applicable beta-Gal-loaded ternary complex through sequential self-assembly in aqueous solution was reported. The complex protected the loaded beta-Gal from degradation and exhibited enhanced and selective enzymatic activity at the tumor site. This novel approach may offer a new strategy for enzyme-prodrug theragnosis.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Qun Wang, Yifan Yang, Dingkang Liu, Yue Ji, Xiangdong Gao, Jun Yin, Wenbing Yao
Summary: The study presents a novel and efficient intracellular protein delivery platform, capable of delivering proteins directly into the cytosol of living cells with high efficacy and safety. This system offers new possibilities for targeting intracellular undruggable targets and expanding the use of protein-based therapeutics, especially for antibodies.
Review
Pharmacology & Pharmacy
Yanhong Liu, Linjiao Chen, Qingyang Shi, Qing Zhao, Hongshuang Ma
Summary: Tumor microenvironment-responsive polypeptide nanogels have excellent biocompatibility and degradability, and can be used for selective delivery of antitumor drugs. These nanogels can release drugs in response to stimuli from tumor tissues or cells, reducing side effects and improving efficacy.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Lixia Pei, Hongyu Ma, Yan Jiang, Handou Zheng, Haiyang Gao
Summary: This paper reports the synthesis and characterization of amphiphilic polyethylene-block-poly(L-lysine) (PE-b-PLL) block copolymers, which self-assembled into spherical micelles with a hydrophobic PE core in aqueous solution. The pH and ionic responsivities of the polymeric micelles were investigated, and it was found that the conformational alteration of PLL from alpha-helix to coil changed the micelle dimensions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Naoto Yoshinaga, Satoshi Uchida, Anjaneyulu Dirisala, Mitsuru Naito, Kensuke Osada, Horacio Cabral, Kazunori Kataoka
Summary: A novel carrier design was introduced to protect and release mRNA in the cytosol for efficient protein expression, balancing stability in the biological milieu and ATP-responsive release through the modulation of structural factors. Furthermore, the optimal formulation was enhanced by incorporating cholesterol moieties for prolonged blood circulation post intravenous injection.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Pharmacology & Pharmacy
Rajeev Sharma, Priya Shrivastava, Laxmikant Gautam, Udita Agrawal, S. Mohana Lakshmi, Suresh P. Vyas
Summary: This article reviews the design, fabrication techniques, and recent advances in the development of block copolymers as drug carrier systems, and discusses their potential applications in improving the physicochemical and pharmacological attributes of bioactives.
DRUG DISCOVERY TODAY
(2023)
Article
Polymer Science
Huiqi Wang, Aman Ullah
Summary: In this study, block copolymer micelles composed of renewable fatty-acid-based hydrophobic block and thermoresponsive hydrophilic block were synthesized and characterized for controlled drug delivery. The self-assembly of block copolymers with variable hydrophobic block length formed spherical nanoparticles with low critical micelle concentration in aqueous media. The in vitro drug release tests showed temperature-triggered response and accelerated drug release at 37 degrees C.
Review
Pharmacology & Pharmacy
Orestis Kontogiannis, Dimitrios Selianitis, Nefeli Lagopati, Natassa Pippa, Stergios Pispas, Maria Gazouli
Summary: The medical application of nanotechnology in drug delivery has made significant progress in treating various human diseases, offering advantages such as targeted drug delivery, low toxicity, and personalized medicine. Innovative drug delivery carriers using polymers, surfactants, and their combinations have been developed and tested pre-clinically, enabling simultaneous delivery of multiple therapeutic entities and combining therapy with diagnosis. This review focuses on the applications of surfactant-based, polymer-based, and mixed surfactant-polymer nanoparticle drug formulations in the medical field, providing detailed information on the materials used, formulation steps, physicochemical characteristics, and pharmacokinetic behavior of these systems.
Article
Polymer Science
Xuechen Yin, David R. O. Hewitt, Bingqian Zheng, Suan P. Quah, Christopher B. Stanley, Robert B. Grubbs, Surita R. Bhatia
Summary: This study presents the nanoscale assembly of PLA-PEOPLA triblock copolymers in water, with a focus on the effect of stereochemistry on micellar properties. Different L/D ratios of PLA blocks were found to impact aggregation numbers and interactions between PLA chains, demonstrating the potential for tuning micellar properties for specific applications.
Article
Chemistry, Multidisciplinary
Ravi Prakash Behere, Rajlaxmi, Neelam Gupta, Susmita Roy, Ram Nayan Gautam, Manoj Kumar Bharty, Chanchal Chakroborty, Biplab Kumar Kuila
Summary: In this study, a luminescent network polymer was successfully demonstrated through a H-bond cross-linking strategy. The network structure formation was confirmed through a combination of FTIR, NMR, XRD, and viscosity analyses. Additionally, the network polymer showed potential for fluorometric detection of alkylating agents at low concentrations and differentiation between alkyl iodides and aromatic iodides.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Nanoscience & Nanotechnology
Haili Wang, Xuan Nie, Wei You, Weiqiang Huang, Guang Chen, Fan Gao, Lei Xia, Lei Zhang, Longhai Wang, Ai-Zong Shen, Kai-Le Wu, Sheng-Gang Ding, Ye-Zi You
Summary: Antimicrobial resistance in Gram-negative bacteria is a serious global public health concern due to their additional outer membrane protection. Current strategies for treating Gram-negative bacteria are still very challenging.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Sharafudheen Pottanam Chali, Suna Azhdari, Anzhela Galstyan, Andre H. Groschel, Bart Jan Ravoo
Summary: Biodegradable supramolecular micelles were prepared by utilizing the host-guest interaction of cyclodextrin and adamantane, with cyclodextrin-initiated polypeptides acting as the hydrophilic corona and adamantane-terminated polycaprolactones serving as the hydrophobic core.
CHEMICAL COMMUNICATIONS
(2021)
Article
Agronomy
Charlotte E. Pugsley, R. Elwyn Isaac, Nicholas J. Warren, Martin Stacey, Calum T. J. Ferguson, Kaat Cappelle, Rosa Dominguez-Espinosa, Olivier J. Cayre
Summary: RNA interference (RNAi)-based strategies using double-stranded RNA (dsRNA) as a species-specific bio-insecticide provide a promising solution for controlling damaging pest infestations. However, the lack of RNAi in certain species when dsRNA is orally administered hinders its effectiveness. In this study, researchers demonstrated the complexation of D. suzukii-specific dsRNA with bespoke diblock copolymers, leading to improved protection and cellular uptake.
PEST MANAGEMENT SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Junan Zhang, Xiaoyun Jiang, Wenyue Luo, Yongjie Mo, Chunyan Dai, Linhua Zhu
Summary: Tumor hypoxia is a common characteristic of most solid tumors and hinders treatment outcomes. In this study, photosensitizer-loaded micelles were prepared and found to effectively enter cells and significantly suppress tumor cell survival when exposed to laser.
Article
Immunology
Alaric C. Siddoway, Brianna M. White, Balaji Narasimhan, Surya K. Mallapragada
Summary: This study describes a new family of nanoadjuvants based on low-molecular-weight Pluronic(R) P123 pentablock copolymers, which exhibit high biocompatibility and enhanced adjuvanticity at lower doses. Animal experiments demonstrate that these nanovaccines can induce high antibody titers, even when used at significantly reduced doses compared to Pluronic(R) F127-based pentablock copolymers.
