B-cell subsets, signaling and their roles in secretion of autoantibodies

The JAK-STAT Pathway: Impact on Human Disease and Therapeutic Intervention

(2015) John J. O'Shea et al.   Annual Review of Medicine

Amplification of IL-21 signalling pathway through Bruton’s tyrosine kinase in human B cell activation

(2015) Sheau-Pey Wang et al.   RHEUMATOLOGY

Tofacitinib, a JAK inhibitor, inhibits human B cell activation in vitro

(2014) Sheau-Pey Wang et al.   ANNALS OF THE RHEUMATIC DISEASES

T Cell Leukemia/Lymphoma 1 and Galectin-1 Regulate Survival/Cell Death Pathways in Human Naive and IgM+ Memory B Cells through Altering Balances in Bcl-2 Family Proteins

(2014) S. J. Tabrizi et al.   JOURNAL OF IMMUNOLOGY

Tofacitinib Suppresses Antibody Responses to Protein Therapeutics in Murine Hosts

(2014) M. Onda et al.   JOURNAL OF IMMUNOLOGY

Increased Syk phosphorylation leads to overexpression of TRAF6 in peripheral B cells of patients with systemic lupus erythematosus

(2014) S Iwata et al.   LUPUS

Defective PTEN regulation contributes to B cell hyperresponsiveness in systemic lupus erythematosus

(2014) X.-n. Wu et al.   Science Translational Medicine

Increased Frequency of a Unique Spleen Tyrosine Kinase Bright Memory B Cell Population in Systemic Lupus Erythematosus

(2014) Sarah J. Fleischer et al.   Arthritis & Rheumatology

Persistent memory B cell down-regulation after 6-year remission induced by rituximab therapy in patients with systemic lupus erythematosus

(2013) S Iwata et al.   LUPUS

B cell or T cell-dominant recurrence after rituximab therapy in patients with SLE

(2012) Shigeru Iwata et al.   ANNALS OF THE RHEUMATIC DISEASES

Efficacy and safety of rituximab in patients with active proliferative lupus nephritis: The lupus nephritis assessment with rituximab study

(2012) Brad H. Rovin et al.   ARTHRITIS AND RHEUMATISM

Btk levels set the threshold for B-cell activation and negative selection of autoreactive B cells in mice

(2012) L. P. Kil et al.   BLOOD

Amplification of Toll-like receptor–mediated signaling through spleen tyrosine kinase in human B-cell activation

(2012) Shigeru Iwata et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Protein phosphorylation and kinome profiling reveal altered regulation of multiple signaling pathways in B lymphocytes from patients with systemic lupus erythematosus

(2010) Taher E. Taher et al.   ARTHRITIS AND RHEUMATISM

PTPN22 gene polymorphisms in autoimmune diseases with special reference to systemic lupus erythematosus disease susceptibility

(2010) V Pradhan et al.   Journal of Postgraduate Medicine

Phenotypic Changes of Lymphocytes in Patients with Systemic Lupus Erythematosus Who Are in Longterm Remission After B Cell Depletion Therapy with Rituximab

(2010) S. IWATA et al.   JOURNAL OF RHEUMATOLOGY

Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma

(2010) R. Eric Davis et al.   NATURE

The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy

(2010) L. A. Honigberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Decreased frequency and activated phenotype of blood CD27 IgD IgM B lymphocytes is a permanent abnormality in systemic lupus erythematosus patients

(2010) Beatriz Rodríguez-Bayona et al.   ARTHRITIS RESEARCH & THERAPY

A retrospective seven-year analysis of the use of B cell depletion therapy in systemic lupus erythematosus at university college london hospital: The first fifty patients

(2009) Tim Y.-T. Lu et al.   ARTHRITIS AND RHEUMATISM

Efficacy and safety of rituximab in moderately-to-severely active systemic lupus erythematosus: The randomized, double-blind, phase ii/iii systemic lupus erythematosus evaluation of rituximab trial

(2009) Joan T. Merrill et al.   ARTHRITIS AND RHEUMATISM

Autoinhibition and adapter function of Syk

(2009) Yogesh Kulathu et al.   IMMUNOLOGICAL REVIEWS

B Cells and Immunological Tolerance

(2009) Nataly Manjarrez-Orduño et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

B cells in autoimmunity

(2009) Thomas Dörner et al.   ARTHRITIS RESEARCH & THERAPY

Interleukin 21 as a target of intervention in autoimmune disease

(2008) R Ettinger et al.   ANNALS OF THE RHEUMATIC DISEASES

An orally bioavailable spleen tyrosine kinase inhibitor delays disease progression and prolongs survival in murine lupus

(2008) Frances Rena Bahjat et al.   ARTHRITIS AND RHEUMATISM

Activated memory B cell subsets correlate with disease activity in systemic lupus erythematosus: Delineation by expression of CD27, IgD, and CD95

(2008) Annett M. Jacobi et al.   ARTHRITIS AND RHEUMATISM

Depletion of autoreactive immunologic memory followed by autologous hematopoietic stem cell transplantation in patients with refractory SLE induces long-term remission through de novo generation of a juvenile and tolerant immune system

(2008) T. Alexander et al.   BLOOD

Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus

(2008) Sergey V Kozyrev et al.   NATURE GENETICS

Association of Systemic Lupus Erythematosus withC8orf13–BLKandITGAM–ITGAX

(2008) Geoffrey Hom et al.   NEW ENGLAND JOURNAL OF MEDICINE

Phenotypic and functional heterogeneity of human memory B cells

(2008) Iñaki Sanz et al.   SEMINARS IN IMMUNOLOGY