Defective PTEN regulation contributes to B cell hyperresponsiveness in systemic lupus erythematosus

MicroRNA-7 inhibits tumor growth and metastasis by targeting the phosphoinositide 3-kinase/Akt pathway in hepatocellular carcinoma

(2012) YuXiang Fang et al.   HEPATOLOGY

MicroRNA-22 promotes cell survival upon UV radiation by repressing PTEN

(2011) Guangyun Tan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Emergence of the PI3-kinase pathway as a central modulator of normal and aberrant B cell differentiation

(2011) GV Baracho et al.   CURRENT OPINION IN IMMUNOLOGY

Monophosphorylation of CD79a and CD79b ITAM Motifs Initiates a SHIP-1 Phosphatase-Mediated Inhibitory Signaling Cascade Required for B Cell Anergy

(2011) Shannon K. O'Neill et al.   IMMUNITY

Overexpression of miR-22 reverses paclitaxel-induced chemoresistance through activation of PTEN signaling in p53-mutated colon cancer cells

(2011) Jian Li et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Loss of the miR-21 allele elevates the expression of its target genes and reduces tumorigenesis

(2011) X. Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EGFR Promotes Lung Tumorigenesis by Activating miR-7 through a Ras/ERK/Myc Pathway That Targets the Ets2 Transcriptional Repressor ERF

(2010) Y.-T. Chou et al.   CANCER RESEARCH

B cell–intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans

(2010) Danielle T. Avery et al.   JOURNAL OF EXPERIMENTAL MEDICINE

miR-22 Forms a Regulatory Loop in PTEN/AKT Pathway and Modulates Signaling Kinetics

(2010) Nadav Bar et al.   PLoS One

The PI3K Isoforms p110  and p110  Are Essential for Pre-B Cell Receptor Signaling and B Cell Development

(2010) F. Ramadani et al.   Science Signaling

Novel IL-21 signaling pathway up-regulates c-Myc and induces apoptosis of diffuse large B-cell lymphomas

(2009) K. A. Sarosiek et al.   BLOOD

PI3 Kinase Signals BCR-Dependent Mature B Cell Survival

(2009) Lakshmi Srinivasan et al.   CELL

Distinct response in maintenance of human naive and memory B cells via IL-21 receptor and TCL1/Akt pathways

(2009) Haruo Nagumo et al.   CELLULAR IMMUNOLOGY

Genetic dissection of the miR-17 92 cluster of microRNAs in Myc-induced B-cell lymphomas

(2009) P. Mu et al.   GENES & DEVELOPMENT

Suppression of Phosphatidylinositol 3,4,5-Trisphosphate Production Is a Key Determinant of B Cell Anergy

(2009) Cecille D. Browne et al.   IMMUNITY

Elevated Production of B Cell Chemokine CXCL13 is Correlated with Systemic Lupus Erythematosus Disease Activity

(2009) C. K. Wong et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Identification and Characterization of a Human CD5+ Pre-Naive B Cell Population

(2009) J. Lee et al.   JOURNAL OF IMMUNOLOGY

Tenets of PTEN Tumor Suppression

(2008) Leonardo Salmena et al.   CELL

BCR-mediated apoptosis associated with negative selection of immature B cells is selectively dependent on Pten

(2008) Shuhua Cheng et al.   CELL RESEARCH

Interleukin-21: Basic Biology and Implications for Cancer and Autoimmunity

(2007) Rosanne Spolski et al.   Annual Review of Immunology

Targeting phosphoinositide 3-kinase—Moving towards therapy

(2007) Romina Marone et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS