Defective NCOA4-dependent ferroptosis in senescent fibroblasts retards diabetic wound healing

Aging is associated with increased brain iron through cortex-derived hepcidin expression

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Targeting SLC7A11 improves efferocytosis by dendritic cells and wound healing in diabetes

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Ferroptosis and ferritinophagy in diabetes complications

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Cellular Senescence in Acute and Chronic Wound Repair

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Long term high glucose exposure induces premature senescence in retinal endothelial cells

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Early Worsening of Diabetic Nephropathy in Type 2 Diabetes After Rapid Improvement in Chronic Severe Hyperglycemia

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Ferroptosis: mechanisms, biology and role in disease

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HMGB1 regulates ferroptosis through Nrf2 pathway in mesangial cells in response to high glucose

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Diabetes fuels periodontal lesions via GLUT1-driven macrophage inflammaging

(2021) Qian Wang et al.   International Journal of Oral Science

Evidence of dysregulated iron homeostasis in newly diagnosed diabetics, but not in pre-diabetics

(2021) Padmanaban Venkatesan et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

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Precise Diabetic Wound Therapy: PLS Nanospheres Eliminate Senescent Cells via DPP4 Targeting and PARP1 Activation

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Cysteine Toxicity Drives Age-Related Mitochondrial Decline by Altering Iron Homeostasis

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Wound senescence: A functional link between diabetes and ageing?

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UVA irradiation increases ferrous iron release from human skin fibroblast and endothelial cell ferritin: Consequences for cell senescence and aging

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Fibroblast Heterogeneity in Wound Healing: Hurdles to Clinical Translation

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Hypoxia inhibits ferritinophagy, increases mitochondrial ferritin, and protects from ferroptosis

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Autophagy in Human Diseases

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Ferroptosis is a type of autophagy-dependent cell death

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Elevated Local Senescence in Diabetic Wound Healing Is Linked to Pathological Repair via CXCR2

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The Microbiome and Aging

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Cellular senescence: at the nexus between ageing and diabetes

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ROS-mediated autophagy increases intracellular iron levels and ferroptosis by ferritin and transferrin receptor regulation

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Current Challenges and Opportunities in the Prevention and Management of Diabetic Foot Ulcers

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Fibroblast heterogeneity: implications for human disease

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Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis

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Short-term sustained hyperglycaemia fosters an archetypal senescence-associated secretory phenotype in endothelial cells and macrophages

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Uncoupled iron homeostasis in type 2 diabetes mellitus

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Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states

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Diabetic Foot Ulcers and Their Recurrence

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Interactions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson's disease

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Autophagy impairment with lysosomal and mitochondrial dysfunction is an important characteristic of oxidative stress-induced senescence

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Autophagy promotes ferroptosis by degradation of ferritin

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Regulation of Ferroptotic Cancer Cell Death by GPX4

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Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

(2014) Joseph D. Mancias et al.   NATURE

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Iron and Diabetes Risk

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The Long and Short of Telomere Length and Diabetes

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Aging-related changes in the iron status of skeletal muscle

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Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

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Isolation and short-term culture of primary keratinocytes, hair follicle populations and dermal cells from newborn mice and keratinocytes from adult mice for in vitro analysis and for grafting to immunodeficient mice

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Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

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