Tris (dibenzylideneacetone) dipalladium: a small-molecule palladium complex is effective in inducing apoptosis in chronic lymphocytic leukemia B-cells

Targeted Axl Inhibition Primes Chronic Lymphocytic Leukemia B Cells to Apoptosis and Shows Synergistic/Additive Effects in Combination with BTK Inhibitors

(2015) S. Sinha et al.   CLINICAL CANCER RESEARCH

Pharmacological and Protein Profiling Suggests Venetoclax (ABT-199) as Optimal Partner with Ibrutinib in Chronic Lymphocytic Leukemia

(2015) F. Cervantes-Gomez et al.   CLINICAL CANCER RESEARCH

Tris DBA palladium overcomes hypoxia-mediated drug resistance in multiple myeloma

(2015) Pilar de la Puente et al.   LEUKEMIA & LYMPHOMA

MCL-1 and BCL-xL-dependent resistance to the BCL-2 inhibitor ABT-199 can be overcome by preventing PI3K/AKT/mTOR activation in lymphoid malignancies

(2015) G S Choudhary et al.   Cell Death & Disease

Stimulation of the B-cell receptor activates the JAK2/STAT3 signaling pathway in chronic lymphocytic leukemia cells

(2014) U. Rozovski et al.   BLOOD

Activation of the PI3K/AKT pathway by microRNA-22 results in CLL B-cell proliferation

(2014) F Palacios et al.   LEUKEMIA

STAT3-Activated GM-CSFR  Translocates to the Nucleus and Protects CLL Cells from Apoptosis

(2014) P. Li et al.   MOLECULAR CANCER RESEARCH

Valproic acid enhances fludarabine-induced apoptosis mediated by ROS and involving decreased AKT and ATM activation in B-cell-lymphoid neoplastic cells

(2013) Ju-Yoon Yoon et al.   APOPTOSIS

Akt inhibitor MK2206 selectively targets CLL B-cell receptor induced cytokines, mobilizes lymphocytes and synergizes with bendamustine to induce CLL apoptosis

(2013) Wei Ding et al.   BRITISH JOURNAL OF HAEMATOLOGY

The phosphatidylinositol 3-kinases (PI3K) inhibitor GS-1101 synergistically potentiates histone deacetylase inhibitor-induced proliferation inhibition and apoptosis through the inactivation of PI3K and extracellular signal-regulated kinase pathways

(2013) Juraj Bodo et al.   BRITISH JOURNAL OF HAEMATOLOGY

Ribosomal Protein S6, a Target of Rapamycin, Is Involved in the Regulation of rRNA Genes by Possible Epigenetic Changes inArabidopsis

(2013) Yun-Kyoung Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BTK inhibition targets in vivo CLL proliferation through its effects on B-cell receptor signaling activity

(2013) S Cheng et al.   LEUKEMIA

The tumor suppressor axis p53/miR-34a regulates Axl expression in B-cell chronic lymphocytic leukemia: implications for therapy in p53-defective CLL patients

(2013) J Boysen et al.   LEUKEMIA

Targeting BTK with Ibrutinib in Relapsed Chronic Lymphocytic Leukemia

(2013) John C. Byrd et al.   NEW ENGLAND JOURNAL OF MEDICINE

The PI3-Kinase Delta Inhibitor Idelalisib (GS-1101) Targets Integrin-Mediated Adhesion of Chronic Lymphocytic Leukemia (CLL) Cell to Endothelial and Marrow Stromal Cells

(2013) Stefania Fiorcari et al.   PLoS One

Overexpression of the autoimmunity-associated phosphatase PTPN22 promotes survival of antigen-stimulated CLL cells by selectively activating AKT

(2012) R. Negro et al.   BLOOD

Prognostic significance and function of phosphorylated ribosomal protein S6 in esophageal squamous cell carcinoma

(2012) Seok-Hyung Kim et al.   MODERN PATHOLOGY

Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks

(2011) Brian Magnuson et al.   BIOCHEMICAL JOURNAL

The novel receptor tyrosine kinase Axl is constitutively active in B-cell chronic lymphocytic leukemia and acts as a docking site of nonreceptor kinases: implications for therapy

(2010) A. K. Ghosh et al.   BLOOD

STAT3 is constitutively phosphorylated on serine 727 residues, binds DNA, and activates transcription in CLL cells

(2010) I. Hazan-Halevy et al.   BLOOD

Platelet-derived growth factor (PDGF)-PDGF receptor interaction activates bone marrow-derived mesenchymal stromal cells derived from chronic lymphocytic leukemia: implications for an angiogenic switch

(2010) W. Ding et al.   BLOOD

ATP-mediated protein kinase B Akt/mammalian target of rapamycin mTOR/p70 ribosomal S6 protein p70S6 kinase signaling pathway activation promotes improvement of locomotor function after spinal cord injury in rats

(2010) L.Y. Hu et al.   NEUROSCIENCE

Aberrant regulation of pVHL levels by microRNA promotes the HIF/VEGF axis in CLL B cells

(2009) A. K. Ghosh et al.   BLOOD

Curcumin Inhibits Prosurvival Pathways in Chronic Lymphocytic Leukemia B Cells and May Overcome Their Stromal Protection in Combination with EGCG

(2009) A. K. Ghosh et al.   CLINICAL CANCER RESEARCH

Regulation of ribosomal protein S6 kinases by ubiquitination

(2008) Mong-Lien Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines

(2008) M. Hallek et al.   BLOOD

Tris (Dibenzylideneacetone) Dipalladium, a N-Myristoyltransferase-1 Inhibitor, Is Effective against Melanoma Growth In vitro and In vivo

(2008) S. S. Bhandarkar et al.   CLINICAL CANCER RESEARCH

Regulation and localization of ribosomal protein S6 kinase 1 isoforms

(2008) Doyil Kim et al.   GROWTH FACTORS