The aftermath of the interplay between the endoplasmic reticulum stress response and redox signaling

Role of Endoplasmic Reticulum Stress Sensor IRE1α in Cellular Physiology, Calcium, ROS Signaling, and Metaflammation

(2020) Thoufiqul Alam Riaz et al.   Cells

Endoplasmic Reticulum (ER) Stress Response Failure in Diseases

(2020) Kashi Raj Bhattarai et al.   TRENDS IN CELL BIOLOGY

Hepatic Sdf2l1 controls feeding-induced ER stress and regulates metabolism

(2019) Takayoshi Sasako et al.   Nature Communications

Interplay between Redox Signaling, Oxidative Stress, and Unfolded Protein Response (UPR) in Pathogenesis of Human Diseases

(2019) Tomasz Poplawski et al.   Oxidative Medicine and Cellular Longevity

Hepatitis B Surface Antigen Activates Unfolded Protein Response in Forming Ground Glass Hepatocytes of Chronic Hepatitis B

(2019) Yao Li et al.   Viruses-Basel

Obesity May Accelerate the Aging Process

(2019) Valentina Salvestrini et al.   Frontiers in Endocrinology

Grp78 Loss in Epithelial Progenitors Reveals an Age-Linked Role for ER Stress in Pulmonary Fibrosis

(2019) Zea Borok et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Regulation of autophagy by canonical and non-canonical ER stress responses

(2019) Monika Bhardwaj et al.   SEMINARS IN CANCER BIOLOGY

eIF2B Mechanisms of Action and Regulation: A Thermodynamic View

(2018) Andrew M. Bogorad et al.   BIOCHEMISTRY

Crosstalk between endoplasmic reticulum stress and brain inflammation in Alzheimer's disease

(2018) Luis E. Santos et al.   NEUROPHARMACOLOGY

Quality Control in the Endoplasmic Reticulum: Crosstalk between ERAD and UPR pathways

(2018) Jiwon Hwang et al.   TRENDS IN BIOCHEMICAL SCIENCES

ER Proteostasis Control of Neuronal Physiology and Synaptic Function

(2018) Gabriela Martínez et al.   TRENDS IN NEUROSCIENCES

Redox crosstalk at endoplasmic reticulum (ER) membrane contact sites (MCS) uses toxic waste to deliver messages

(2018) Edgar Djaha Yoboue et al.   Cell Death & Disease

Coordination between Two Branches of the Unfolded Protein Response Determines Apoptotic Cell Fate

(2018) Tsun-Kai Chang et al.   MOLECULAR CELL

Activation of PERK-eIF2α-ATF4-CHOP axis triggered by excessive ER stress contributes to lead-induced nephrotoxicity

(2018) Min-Ge Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Potential Application of Ixeris dentata in the Prevention and Treatment of Aging-Induced Dry Mouth

(2018) Kashi Bhattarai et al.   Nutrients

Redox signaling and unfolded protein response coordinate cell fate decisions under ER stress

(2018) Zhe Zhang et al.   Redox Biology

New Insights into the Physiological Role of Endoplasmic Reticulum-Associated Degradation

(2017) Ling Qi et al.   TRENDS IN CELL BIOLOGY

Dysregulated expression of proteins associated with ER stress, autophagy and apoptosis in tissues from nonalcoholic fatty liver disease

(2017) Seungwoo Lee et al.   Oncotarget

Blocking iNOS and endoplasmic reticulum stress synergistically improves insulin resistance in mice

(2017) Tamires M. Zanotto et al.   Molecular Metabolism

Novel Protein Disulfide Isomerase Inhibitor with Anticancer Activity in Multiple Myeloma

(2016) S. Vatolin et al.   CANCER RESEARCH

Endoplasmic reticulum stress enhances fibrosis through IRE1α‐mediated degradation of miR‐150 and XBP‐1 splicing

(2016) Femke Heindryckx et al.   EMBO Molecular Medicine

The integrated stress response

(2016) Karolina Pakos‐Zebrucka et al.   EMBO REPORTS

Endoplasmic Reticulum Stress and Associated ROS

(2016) Hafiz Zeeshan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Redox Nanodomains Are Induced by and Control Calcium Signaling at the ER-Mitochondrial Interface

(2016) David M. Booth et al.   MOLECULAR CELL

Protein misfolding in the endoplasmic reticulum as a conduit to human disease

(2016) Miao Wang et al.   NATURE

Endoplasmic reticulum proteostasis in hepatic steatosis

(2016) Andrei Baiceanu et al.   Nature Reviews Endocrinology

Protein Quality Control in Health and Disease

(2016) Tatyana Dubnikov et al.   Cold Spring Harbor Perspectives in Biology

Are free radicals involved in thiol-based redox signaling?

(2015) Christine C. Winterbourn   FREE RADICAL BIOLOGY AND MEDICINE

The balance between adaptive and apoptotic unfolded protein responses regulates β-cell death under ER stress conditions through XBP1, CHOP and JNK

(2015) Jeng Yie Chan et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Protein folding guides disulfide bond formation

(2015) Meng Qin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

S-Nitrosylation links obesity-associated inflammation to endoplasmic reticulum dysfunction

(2015) L. Yang et al.   SCIENCE

Defective podocyte insulin signalling through p85-XBP1 promotes ATF6-dependent maladaptive ER-stress response in diabetic nephropathy

(2015) Thati Madhusudhan et al.   Nature Communications

Regulation of the unfolded protein response via S-nitrosylation of sensors of endoplasmic reticulum stress

(2015) Ryosuke Nakato et al.   Scientific Reports

Deficiency of IRE1 and PERK Signal Pathways in Systemic Lupus Erythematosus

(2014) Qiyao Cheng et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Oxidative Protein Folding: Nature's Knotty Challenge

(2014) Chad R. Borges et al.   ANTIOXIDANTS & REDOX SIGNALING

BRD7 Regulates XBP1s’ Activity and Glucose Homeostasis through Its Interaction with the Regulatory Subunits of PI3K

(2014) Sang Won Park et al.   Cell Metabolism

Impaired endoplasmic reticulum stress response in bipolar disorder: cellular evidence of illness progression

(2014) Bianca Pfaffenseller et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

TLR dependent XBP-1 activation induces an autocrine loop in rheumatoid arthritis synoviocytes

(2014) Sinisa Savic et al.   JOURNAL OF AUTOIMMUNITY

Redox controls UPR to control redox

(2014) D. Eletto et al.   JOURNAL OF CELL SCIENCE

Endoplasmic Reticulum Stress-Activated Transcription Factor ATF6  Requires the Disulfide Isomerase PDIA5 To Modulate Chemoresistance

(2014) A. Higa et al.   MOLECULAR AND CELLULAR BIOLOGY

Structures of the Sec61 complex engaged in nascent peptide translocation or membrane insertion

(2014) Marko Gogala et al.   NATURE

Getting RIDD of RNA: IRE1 in cell fate regulation

(2014) M. Maurel et al.   TRENDS IN BIOCHEMICAL SCIENCES

Free Radicals in Cross Talk Between Autophagy and Apoptosis

(2013) Vitaliy O. Kaminskyy et al.   ANTIOXIDANTS & REDOX SIGNALING

Increased Expression of Endoplasmic Reticulum Stress and Unfolded Protein Response Genes in Peripheral Blood Mononuclear Cells From Patients With Limited Cutaneous Systemic Sclerosis and Pulmonary Arterial Hypertension

(2013) Stefania Lenna et al.   ARTHRITIS AND RHEUMATISM

ER stress-induced cell death mechanisms

(2013) Renata Sano et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Loss of Cytochrome c Oxidase Promotes RAS-Dependent ROS Production from the ER Resident NADPH Oxidase, Yno1p, in Yeast

(2013) Jane E. Leadsham et al.   Cell Metabolism

Activation of NADPH Oxidase 4 in the Endoplasmic Reticulum Promotes Cardiomyocyte Autophagy and Survival During Energy Stress Through the Protein Kinase RNA-Activated-Like Endoplasmic Reticulum Kinase/Eukaryotic Initiation Factor 2α/Activating Transcription Factor 4 Pathway

(2013) Sebastiano Sciarretta et al.   CIRCULATION RESEARCH

Ero1-α and PDIs constitute a hierarchical electron transfer network of endoplasmic reticulum oxidoreductases

(2013) Kazutaka Araki et al.   JOURNAL OF CELL BIOLOGY

Roles for ATF6 and the sarco/endoplasmic reticulum protein quality control system in the heart

(2013) Christopher C. Glembotski   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Paneth cells as a site of origin for intestinal inflammation

(2013) Timon E. Adolph et al.   NATURE

Protein Folding Drives Disulfide Formation

(2012) Pallav Kosuri et al.   CELL

C/EBP homologous protein contributes to cytokine-induced pro-inflammatory responses and apoptosis in β-cells

(2012) F Allagnat et al.   CELL DEATH AND DIFFERENTIATION

IRE1α Induces Thioredoxin-Interacting Protein to Activate the NLRP3 Inflammasome and Promote Programmed Cell Death under Irremediable ER Stress

(2012) Alana G. Lerner et al.   Cell Metabolism

Unfolded protein response

(2012) Stewart Siyan Cao et al.   CURRENT BIOLOGY

An Involvement of Oxidative Stress in Endoplasmic Reticulum Stress and Its Associated Diseases

(2012) Bidur Bhandary et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The impact of the unfolded protein response on human disease

(2012) Shiyu Wang et al.   JOURNAL OF CELL BIOLOGY

Vitiligo-Inducing Phenols Activate the Unfolded Protein Response in Melanocytes Resulting in Upregulation of IL6 and IL8

(2012) Siavash Toosi et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

(2012) Claudio Hetz   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Erv2 and Quiescin Sulfhydryl Oxidases: Erv-Domain Enzymes Associated with the Secretory Pathway

(2011) Carolyn S. Sevier   ANTIOXIDANTS & REDOX SIGNALING

The small GTPase Rac1 is a novel binding partner of Bcl-2 and stabilizes its antiapoptotic activity

(2011) R. Velaithan et al.   BLOOD

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

(2011) Ira Tabas et al.   NATURE CELL BIOLOGY

The Unfolded Protein Response: Integrating Stress Signals Through the Stress Sensor IRE1α

(2011) Claudio Hetz et al.   PHYSIOLOGICAL REVIEWS

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Free radicals and antioxidants – quo vadis?

(2011) Barry Halliwell   TRENDS IN PHARMACOLOGICAL SCIENCES

Redox State of the Endoplasmic Reticulum Is Controlled by Ero1L-alpha and Intraluminal Calcium

(2010) Balázs Enyedi et al.   ANTIOXIDANTS & REDOX SIGNALING

Oxidative Protein Folding and the Quiescin–Sulfhydryl Oxidase Family of Flavoproteins

(2010) Vamsi K. Kodali et al.   ANTIOXIDANTS & REDOX SIGNALING

The Endoplasmic Reticulum Stress-C/EBP Homologous Protein Pathway-Mediated Apoptosis in Macrophages Contributes to the Instability of Atherosclerotic Plaques

(2010) Hiroto Tsukano et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Signaling cell death from the endoplasmic reticulum stress response

(2010) Gordon C Shore et al.   CURRENT OPINION IN CELL BIOLOGY

Recycling of peroxiredoxin IV provides a novel pathway for disulphide formation in the endoplasmic reticulum

(2010) Timothy J Tavender et al.   EMBO JOURNAL

Disulphide production by Ero1α–PDI relay is rapid and effectively regulated

(2010) Christian Appenzeller-Herzog et al.   EMBO JOURNAL

The unfolded protein response in human skeletal muscle is not involved in the onset of glucose tolerance impairment induced by a fat-rich diet

(2010) Louise Deldicque et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

Induction of the unfolded protein response and cell death pathway in Alzheimer's disease, but not in aged Tg2576 mice

(2010) Jin Hwan Lee et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

The sites and topology of mitochondrial superoxide production

(2010) Martin D. Brand   EXPERIMENTAL GERONTOLOGY

A structural overview of the PDI family of proteins

(2010) Guennadi Kozlov et al.   FEBS Journal

NADPH oxidase links endoplasmic reticulum stress, oxidative stress, and PKR activation to induce apoptosis

(2010) Gang Li et al.   JOURNAL OF CELL BIOLOGY

ERO1-β, a pancreas-specific disulfide oxidase, promotes insulin biogenesis and glucose homeostasis

(2010) Ester Zito et al.   JOURNAL OF CELL BIOLOGY

TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages

(2010) Fabio Martinon et al.   NATURE IMMUNOLOGY

The regulatory subunits of PI3K, p85α and p85β, interact with XBP-1 and increase its nuclear translocation

(2010) Sang Won Park et al.   NATURE MEDICINE

Oxidative Folding: Cellular Strategies for Dealing with the Resultant Equimolar Production of Reactive Oxygen Species

(2009) Yuichiro Shimizu et al.   ANTIOXIDANTS & REDOX SIGNALING

Protein disulphide isomerase protects against protein aggregation and is S-nitrosylated in amyotrophic lateral sclerosis

(2009) Adam K. Walker et al.   BRAIN

The unfolded protein response during prostate cancer development

(2009) Alex Yick-Lun So et al.   CANCER AND METASTASIS REVIEWS

Reduced Apoptosis and Plaque Necrosis in Advanced Atherosclerotic Lesions of Apoe−/− and Ldlr−/− Mice Lacking CHOP

(2009) Edward Thorp et al.   Cell Metabolism

GRP78 expression inhibits insulin and ER stress–induced SREBP-1c activation and reduces hepatic steatosis in mice

(2009) Hélène L. Kammoun et al.   JOURNAL OF CLINICAL INVESTIGATION

Cardioprotection by metabolic shut-down and gradual wake-up

(2009) Lindsay S. Burwell et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis

(2009) Yiguo Wang et al.   NATURE

A role for motoneuron subtype–selective ER stress in disease manifestations of FALS mice

(2009) Smita Saxena et al.   NATURE NEUROSCIENCE

The role of inflammation in insulitis and β-cell loss in type 1 diabetes

(2009) Décio L. Eizirik et al.   Nature Reviews Endocrinology

Subcellular localization of Nox4 and regulation in diabetes

(2009) K. Block et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disulfide Formation in the ER and Mitochondria: Two Solutions to a Common Process

(2009) J. Riemer et al.   SCIENCE

Evolutionary and Structural Insights Into the Multifaceted Glutathione Peroxidase (Gpx) Superfamily

(2008) Stefano Toppo et al.   ANTIOXIDANTS & REDOX SIGNALING

Overexpression of toll-like receptors 3 and 4 in synovial tissue from patients with early rheumatoid arthritis: Toll-like receptor expression in early and longstanding arthritis

(2008) Caroline Ospelt et al.   ARTHRITIS AND RHEUMATISM

Oxidative Protein Folding in Vitro: A Study of the Cooperation between Quiescin-Sulfhydryl Oxidase and Protein Disulfide Isomerase†

(2008) Pumtiwitt C. Rancy et al.   BIOCHEMISTRY

Antimycin A and lipopolysaccharide cause the leakage of superoxide radicals from rat liver mitochondria

(2008) Christina Piskernik et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

SRP Keeps Polypeptides Translocation-Competent by Slowing Translation to Match Limiting ER-Targeting Sites

(2008) Asvin K.K. Lakkaraju et al.   CELL

XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease

(2008) Arthur Kaser et al.   CELL

Oxidized Low-Density Lipoproteins Trigger Endoplasmic Reticulum Stress in Vascular Cells

(2008) Marie Sanson et al.   CIRCULATION RESEARCH

Thioredoxin-interacting protein deficiency induces Akt/Bcl-xL signaling and pancreatic beta-cell mass and protects against diabetes

(2008) Junqin Chen et al.   FASEB JOURNAL

Chop deletion reduces oxidative stress, improves β cell function, and promotes cell survival in multiple mouse models of diabetes

(2008) Benbo Song et al.   JOURNAL OF CLINICAL INVESTIGATION

Aging Impairs the Unfolded Protein Response to Sleep Deprivation and Leads to Proapoptotic Signaling

(2008) N. Naidoo et al.   JOURNAL OF NEUROSCIENCE

Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities

(2008) Inki Kim et al.   NATURE REVIEWS DRUG DISCOVERY

Molecular Mechanisms of Angiotensin II–Mediated Mitochondrial Dysfunction

(2007) Abdulrahman K. Doughan et al.   CIRCULATION RESEARCH

The role of the unfolded protein response in the heart

(2007) Christopher C. Glembotski   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY