Article
Biochemistry & Molecular Biology
Paola De Sanctis, Giuseppe Filardo, Provvidenza Maria Abruzzo, Annalisa Astolfi, Alessandra Bolotta, Valentina Indio, Alessandro Di Martino, Christian Hofer, Helmut Kern, Stefan Loefler, Maurilio Marcacci, Marina Marini, Sandra Zampieri, Cinzia Zucchini
Summary: The study found that exercise training helped skeletal muscle counteract age-related sarcopenia by inducing a wide range of adaptations, sustained by the expression of protein-coding genes. Non-coding RNAs also play a crucial role in orchestrating gene expression during this process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Geriatrics & Gerontology
Alessio Molfino, Marc Beltra, Maria Ida Amabile, Roberta Belli, Giovanni Birolo, Elena Belloni, Serena De Lucia, Lorena Garcia-Castillo, Fabio Penna, Giovanni Imbimbo, Giuseppe Nigri, Barbara Pardini, Paola Costelli, Maurizio Muscaritoli
Summary: This study analyzed small non-coding RNAs (sncRNAs) in patients with gastrointestinal cancer and found dysregulation of muscle-specific microRNAs in cancer-induced muscle wasting. The study also discovered an association between changes in circulating microRNAs and the level of muscularity at body composition analysis. SncRNAs in muscle were assessed by RNAseq, while circulating microRNAs were evaluated by qPCR.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Agriculture, Dairy & Animal Science
Nicolas Busse, Madison L. Gonzalez, Mackenzie L. Krason, Sally E. Johnson
Summary: Consumption of HMB increased the percentage of type IIA and IIA/X muscle fibers in the GM, but did not improve athletic performance in horses. Additionally, HMB supplementation did not have measurable effects on the biomechanical properties of the muscles in horses.
JOURNAL OF ANIMAL SCIENCE
(2021)
Review
Medicine, Research & Experimental
Colin Harper, Venkatesh Gopalan, Jorming Goh
Summary: This review examines the cellular and molecular changes in skeletal muscle mitochondria during aging, particularly focusing on the efficiency of mitochondrial coupling and its impact on muscle function decline. It also discusses how different exercise modalities can potentially reverse these changes and delay the onset of sarcopenia. Additional concepts such as mitophagy and the implications of muscle fiber type changes with sarcopenia on mitochondrial function are also integrated in this review.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Anjali Bhat, Rafay Abu, Sankarasubramanian Jagadesan, Neetha Nanoth Vellichirammal, Ved Vasishtha Pendyala, Li Yu, Tara L. Rudebush, Chittibabu Guda, Irving H. Zucker, Vikas Kumar, Lie Gao
Summary: Exercise training improves skeletal muscle health through various adaptative pathways. Nrf2, an important antioxidant transcription factor, is crucial for the adaptative responses and beneficial effects of exercise on muscle. The study suggests that Nrf2 plays a critical role in the adaptive effects of skeletal muscle and its response to exercise training.
Article
Biochemistry & Molecular Biology
Pia Apablaza, Juan Carlos Borquez, Rodrigo Mendoza, Monica Silva, Gladys Tapia, Alejandra Espinosa, Rodrigo Troncoso, Luis A. Videla, Nevenka Juretic, Andrea del Campo
Summary: Increase in body fat leads to changes in skeletal muscle and accelerates sarcopenia, known as sarco-obesity or sarcopenic obesity. Obesity affects the skeletal muscle's ability to oxidize glucose and causes mitochondrial dysfunction. Exercise improves mitochondrial dysfunction, but the effects on the mitochondrial unfolded protein response (UPRmt) in the skeletal muscle are not well understood. This study aimed to investigate the UPRmt response to exercise in obese mice and its association with skeletal muscle function improvement.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Javier Botella, Nicholas A. Jamnick, Cesare Granata, Amanda J. Genders, Enrico Perri, Tamim Jabar, Andrew Garnham, Michael Lazarou, David J. Bishop
Summary: Autophagy is an important mechanism for cells to degrade old or dysfunctional proteins and organelles. The effects of exercise on autophagosome content markers differ between rodents and humans. The decrease in LC3B-II protein levels induced by exercise in humans does not reflect a decreased autophagy flux.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Joshua C. Drake, Rebecca J. Wilson, Rhianna C. Laker, Yuntian Guan, Hannah R. Spaulding, Anna S. Nichenko, Wenqing Shen, Huayu Shang, Maya Dorn, Kian Huang, Mei Zhang, Aloka B. Bandara, Matthew H. Brisendine, Jennifer A. Kashatus, Poonam R. Sharma, Alexander Young, Jitendra Gautam, Ruofan Cao, Horst Wallrabe, Paul A. Chang, Michael Wong, Eric M. Desjardins, Simon A. Hawley, George J. Christ, David F. Kashatus, Clint L. Miller, Matthew J. Wolf, Ammasi Periasamy, Gregory R. Steinberg, D. Grahame Hardie, Zhen Yan
Summary: Mitochondria form a complex, interconnected reticulum maintained through coordination among biogenesis, dynamic fission, fusion and mitophagy in response to various cues. Specific isoforms of AMP-activated protein kinase are localized on the outer mitochondrial membrane and vary in activation across the reticulum in response to energetic stress. The discovery highlights the complexity of sensing cellular energetics in vivo and its implications for targeting mitochondrial energetics in disease treatment.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Sport Sciences
Christopher Latella, Daniel van den Hoek, Milo Wolf, Patroklos Androulakis-Korakakis, James P. Fisher, James Steele
Summary: This study explored strength adaptations in powerlifting athletes and found that the greatest strength gains occurred in the early phase of participation. Females tended to progress faster, while females with lower baseline strength and older males may experience some strength decline. These findings suggest that consistent strength training can improve strength across different age groups and mitigate age-related declines in strength.
Article
Sport Sciences
M. O. S. T. A. F. A. M. ALI, R. Y. A. N. P. MCMILLAN, D. A. N. E. W. FAUSNACHT, J. O. H. N. W. KAVANAUGH, M. O. R. D. E. C. A. I. M. HARVEY, J. O. S. E. P. H. R. STEVENS, Y. A. R. U. WU, R. A. N. D. A. L. L. L. MYNATT, M. A. T. T. H. E. W. W. HULVER
Summary: This study established a novel muscle-specific TLR4 knockout mouse model and identified mTLR4 as an immunomodulatory effector of exercise-induced metabolic adaptations in skeletal muscle.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2021)
Article
Cardiac & Cardiovascular Systems
Payman Zamani, Elizabeth A. Proto, Neil Wilson, Hossein Fazelinia, Hua Ding, Lynn A. Spruce, Antonio Davila, Thomas C. Hanff, Jeremy A. Mazurek, Stuart B. Prenner, Benoit Desjardins, Kenneth B. Margulies, Daniel P. Kelly, Zoltan Arany, Paschalis-Thomas Doulias, John W. Elrod, Mitchell E. Allen, Shana E. McCormack, Gayatri Maria Schur, Kevin D'Aquilla, Dushyant Kumar, Deepa Thakuri, Karthik Prabhakaran, Michael C. Langham, David C. Poole, Steven H. Seeholzer, Ravinder Reddy, Harry Ischiropoulos, Julio A. Chirinos
Summary: Patients with heart failure with preserved ejection fraction demonstrate impaired skeletal muscle oxidative phosphorylation capacity, reductions in the proportions of Type I myofibres, proteins required for OxPhos, and altered phosphorylation signalling in skeletal muscle, which may contribute to exercise intolerance.
Article
Biochemistry & Molecular Biology
Amy D. Mackay, Erik D. Marchant, Makensie Louw, David M. Thomson, Chad R. Hancock
Summary: This study assessed muscle function in mice following DOX administration and found that exercise may be an effective strategy for preventing muscle fatigue caused by DOX treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Haotian He, Xiqin Lin, Tong Tong, Yudong Xu, Huihui Hong, Jingjing Zhang, Yongjin Xu, Cong Huang, Zhou Zhou
Summary: Cadmium exposure has been shown to impair skeletal muscle function, but exercise can effectively counteract this toxicity by inhibiting lipid metabolism disturbance, suppressing pro-inflammatory cytokine production, and preserving skeletal muscle function. This study provides novel evidence for understanding the toxic effects of cadmium on skeletal muscle and highlights the potential of exercise as a countermeasure for cadmium-induced skeletal muscle impairment at the population level.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Cell Biology
Rafael A. Casuso, Saad Al Fazazi, Francisco J. Ruiz-Ojeda, Julio Plaza-Diaz, Ascension Rueda-Robles, Jeronimo Aragon-Vela, Jesus R. Huertas
Summary: The study tested whether supplementing hydroxytyrosol, the main polyphenol in olive oil, during exercise would modify the molecular regulators of glucose uptake. Results showed that a low-to-moderate dose of hydroxytyrosol might alter the beneficial effect of training on basal AKT phosphorylation and Rac1 activity in rats.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Health Care Sciences & Services
Esdras E. B. Pereira, Darlen C. de Carvalho, Luciana P. C. Leitao, Juliana C. G. Rodrigues, Antonio A. C. Modesto, Evitom C. de Sousa, Sidney E. B. Dos Santos, Marianne R. Fernandes, Ney P. C. dos Santos
Summary: The INDEL polymorphism of the NFkB1 gene (rs28362491) may influence the susceptibility to sarcopenia in the elderly in the Amazon.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Sport Sciences
Felipe Mattioni Maturana, Peter Martus, Stephan Zipfel, Andreas M. Niess
Summary: The study revealed that high-intensity interval exercise was more effective in improving maximal oxygen uptake and flow-mediated dilation compared to moderate-intensity continuous training. Conversely, moderate-intensity continuous training showed superior improvement in glycated hemoglobin. Other physical fitness and metabolic indicators showed no significant differences between the two training methods.
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2021)
Article
Physiology
Felipe Mattioni Maturana, Philipp Schellhorn, Gunnar Erz, Christof Burgstahler, Manuel Widmann, Barbara Munz, Rogerio N. Soares, Juan M. Murias, Ansgar Thiel, Andreas M. Niess
Summary: Our study demonstrates the significant influence of exercise intensity domains and biological variability on individual V?O-2max response. The proportion of non-responders in MICT was one third of the group, while no non-responders were observed in HIIT. In MICT, there were 11 responders out of 21 participants, compared to 20 responders out of 21 participants in HIIT.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Psychology, Multidisciplinary
Katja Dierkes, Felipe Mattioni Maturana, Inka Roesel, Peter Martus, Andreas M. Niess, Ansgar Thiel, Gorden Sudeck
Summary: This study compared acute affective response during three different endurance exercise modalities and found that moderate-intensity continuous exercise elicited the highest positive affective valence. The study also revealed that vigorous-intensity continuous exercise had the highest variability in affective valence. The findings showed differences in affect-intensity relationship between continuous and interval exercise.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Physiology
Felipe Mattioni Maturana, Rogerio N. Soares, Juan M. Murias, Philipp Schellhorn, Gunnar Erz, Christof Burgstahler, Manuel Widmann, Barbara Munz, Ansgar Thiel, Andreas M. Niess
Summary: The study aimed to investigate cardiovascular and metabolic adaptations to exercise training among participants with different levels of responsiveness to (V)dot O(2max), finding that responders showed greater improvements in peak power output, second lactate threshold, and microvascular responsiveness, while non-responders had a greater increase in cycling efficiency. No significant differences were observed in other health-related parameters.
PHYSIOLOGICAL REPORTS
(2021)
Review
Sport Sciences
Daniel A. Keir, Danilo Iannetta, Felipe Mattioni Maturana, John M. Kowalchuk, Juan M. Murias
Summary: This article highlights the importance of non-invasive identification of lactate threshold and respiratory compensation point during incremental exercise through pulmonary gas exchange and ventilatory variables. It also provides practical strategies for explaining the physiological mechanisms, identifying thresholds, and addressing related issues, as well as an online tool for practice and data analysis.
Article
Physiology
Manuel Widmann, Felipe Mattioni Maturana, Christof Burgstahler, Gunnar Erz, Philipp Schellhorn, Annunziata Fragasso, Angelika Schmitt, Andreas M. Niess, Barbara Munz
Summary: MicroRNAs have been found to regulate gene expression in response to exercise, and may contribute to individual differences in training response. This study identified specific microRNAs in skeletal muscle that were affected by different training regimens, and explored their correlation with individual training adaptation. These findings suggest the potential for using microRNA markers to develop personalized exercise recommendations.
PHYSIOLOGICAL REPORTS
(2022)
Article
Geriatrics & Gerontology
Danilo Iannetta, Erin Calaine Inglis, Felipe Mattioni Maturana, Giorgia Spigolon, Silvia Pogliaghi, Juan M. Murias
Summary: This study evaluated the effects of acute sprint interval training (SIT) on aerobic function in older inactive adults compared to their young counterparts. The results showed that SIT can acutely improve aerobic function by speeding the rate of adjustment of oxidative phosphorylation, especially in older adults. However, these beneficial effects are only maintained when the volume of SIT is maximized.
EXPERIMENTAL GERONTOLOGY
(2022)
Article
Environmental Sciences
Simone Schweda, Barbara Munz, Christof Burgstahler, Andreas Michael Niess, Inka Roesel, Gorden Sudeck, Inga Krauss
Summary: Physical exercise has been proven effective for the treatment of chronic diseases, but patients with multiple chronic diseases have not received enough attention in health policies. This pilot trial demonstrates the concept of a 6-month exercise intervention program for individuals at risk or diagnosed with cardiovascular diseases, type 2 diabetes mellitus, overweight, and/or hip/knee osteoarthritis. The intervention aims to increase exercise participation and takes into account individual and environmental factors. The results show significant improvements in exercise participation, cardio-respiratory fitness, muscle strength, and general health.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Education, Scientific Disciplines
Serena Trang, Felipe Mattioni Maturana, Juan M. Murias, Michael R. Herbert, Daniel A. Keir
Summary: In exercise physiology, laboratory components are crucial for applying theoretical concepts to personal exercise experiences and introducing data collection and analysis. The gas exchange threshold (GET) and the respiratory compensation point (RCP) are key exercise thresholds that require proper identification. However, the processing and preparation of data have been time-consuming and challenging for students. This article presents a blended laboratory model featuring the Exercise Thresholds App, which provides immediate feedback and eliminates the need for data postprocessing, allowing students to practice threshold identification skills.
ADVANCES IN PHYSIOLOGY EDUCATION
(2023)
Article
Medicine, General & Internal
Felipe Mattioni Maturana, Rebecca Rolf, Simone Schweda, Max Reimer, Manuel Widmann, Christof Burgstahler, Andreas M. Niess, Inga Krauss, Barbara Munz
Summary: Physical exercise has positive effects on chronic conditions, and leptin may serve as a suitable biomarker in exercise-based lifestyle intervention programs for subjects with multimorbidity.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Sport Sciences
Hannes Gropper, Felipe Mattioni Maturana, Andreas M. Niess, Ansgar Thiel
Summary: Regular exercise is beneficial for improving health. Young inactive adults show significant improvements both physiologically and subjectively after receiving exercise interventions. Different exercise modes and their sequence have a substantial impact on both measured and perceived physical fitness.
FRONTIERS IN SPORTS AND ACTIVE LIVING
(2021)
Meeting Abstract
Sport Sciences
Felipe Mattioni Maturana, Manuel Widmann, Barbara Munz, Ansgar Thiel, Andreas M. Niess
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2021)
Letter
Sport Sciences
Daniel A. Keir, Felipe Mattioni Maturana, Danilo Iannetta, Juan M. Murias