A novel hypoxia-selective epigenetic agent RRx-001 triggers apoptosis and overcomes drug resistance in multiple myeloma cells
出版年份 2016 全文链接
标题
A novel hypoxia-selective epigenetic agent RRx-001 triggers apoptosis and overcomes drug resistance in multiple myeloma cells
作者
关键词
-
出版物
LEUKEMIA
Volume 30, Issue 11, Pages 2187-2197
出版商
Springer Nature
发表日期
2016-04-27
DOI
10.1038/leu.2016.96
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Identification and characterization of DNAzymes targeting DNA methyltransferase I for suppressing bladder cancer proliferation
- (2015) Xiangbo Wang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Synergistic anti-myeloma activity of the proteasome inhibitor marizomib and the IMiD®immunomodulatory drug pomalidomide
- (2015) Deepika S. Das et al. BRITISH JOURNAL OF HAEMATOLOGY
- Safety and activity of RRx-001 in patients with advanced cancer: a first-in-human, open-label, dose-escalation phase 1 study
- (2015) Tony Reid et al. LANCET ONCOLOGY
- Targeting PD1–PDL1 immune checkpoint in plasmacytoid dendritic cell interactions with T cells, natural killer cells and multiple myeloma cells
- (2015) A Ray et al. LEUKEMIA
- Synthetic Lethal Approaches Exploiting DNA Damage in Aggressive Myeloma
- (2015) F. Cottini et al. Cancer Discovery
- Nrf2 activity as a potential biomarker for the pan-epigenetic anticancer agent, RRx-001
- (2015) Shoucheng Ning et al. Oncotarget
- NO to cancer: The complex and multifaceted role of nitric oxide and the epigenetic nitric oxide donor, RRx-001
- (2015) Jan Scicinski et al. Redox Biology
- Nitric oxide: Protein tyrosine phosphorylation and protein S-nitrosylation in cancer
- (2015) Arnold Stern et al. Biomedical Journal
- Episensitization: Therapeutic Tumor Resensitization by Epigenetic Agents: A Review and Reassessment
- (2014) Bryan Oronsky et al. Anti-Cancer Agents in Medicinal Chemistry
- A novel TLR-9 agonist C792 inhibits plasmacytoid dendritic cell-induced myeloma cell growth and enhance cytotoxicity of bortezomib
- (2014) A Ray et al. LEUKEMIA
- STRING v10: protein–protein interaction networks, integrated over the tree of life
- (2014) Damian Szklarczyk et al. NUCLEIC ACIDS RESEARCH
- Rewriting the Epigenetic Code for Tumor Resensitization: A Review
- (2014) Bryan Oronsky et al. Translational Oncology
- The role of epigenetics in the biology of multiple myeloma
- (2014) K Dimopoulos et al. Blood Cancer Journal
- Acute Depletion Redefines the Division of Labor among DNA Methyltransferases in Methylating the Human Genome
- (2014) Rochelle L. Tiedemann et al. Cell Reports
- New Nucleophilic Mechanisms of Ros-Dependent Epigenetic Modifications: Comparison of Aging and Cancer
- (2014) Igor Afanas’ev Aging and Disease
- Global methylation analysis identifies prognostically important epigenetically inactivated tumor suppressor genes in multiple myeloma
- (2013) M. F. Kaiser et al. BLOOD
- Myeloma Is Characterized by Stage-Specific Alterations in DNA Methylation That Occur Early during Myelomagenesis
- (2013) C. J. Heuck et al. JOURNAL OF IMMUNOLOGY
- Epigenetic Modulating Agents as a New Therapeutic Approach in Multiple Myeloma
- (2013) Ken Maes et al. Cancers
- Hypoxia promotes dissemination of multiple myeloma through acquisition of epithelial to mesenchymal transition-like features
- (2012) A. K. Azab et al. BLOOD
- A Small Molecule Inhibitor of Ubiquitin-Specific Protease-7 Induces Apoptosis in Multiple Myeloma Cells and Overcomes Bortezomib Resistance
- (2012) Dharminder Chauhan et al. CANCER CELL
- Protein S-nitrosylation and cancer
- (2012) Zhaoqing Wang CANCER LETTERS
- Dinitroazetidines Are a Novel Class of Anticancer Agents and Hypoxia-Activated Radiation Sensitizers Developed from Highly Energetic Materials
- (2012) S. Ning et al. CANCER RESEARCH
- Understanding the hypoxic niche of multiple myeloma: therapeutic implications and contributions of mouse models
- (2012) J. Hu et al. Disease Models & Mechanisms
- Maintenance of DNA methylation: Dnmt3b joins the dance
- (2012) Emma L. Walton et al. Epigenetics
- Small Molecule Modulators of Keap1-Nrf2-ARE Pathway as Potential Preventive and Therapeutic Agents
- (2012) Sadagopan Magesh et al. MEDICINAL RESEARCH REVIEWS
- DNA damage induces reactive oxygen species generation through the H2AX-Nox1/Rac1 pathway
- (2012) M A Kang et al. Cell Death & Disease
- Consensus recommendations for standard investigative workup: report of the International Myeloma Workshop Consensus Panel 3
- (2011) M. Dimopoulos et al. BLOOD
- Oncogenomics to Target Myeloma in the Bone Marrow Microenvironment
- (2011) Kenneth C. Anderson CLINICAL CANCER RESEARCH
- The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1
- (2011) Max Felle et al. NUCLEIC ACIDS RESEARCH
- Aberrant global methylation patterns affect the molecular pathogenesis and prognosis of multiple myeloma
- (2010) B. A. Walker et al. BLOOD
- Low bone marrow oxygen tension and hypoxia-inducible factor-1α overexpression characterize patients with multiple myeloma: role on the transcriptional and proangiogenic profiles of CD138+ cells
- (2010) S Colla et al. LEUKEMIA
- DNMT1 Stability Is Regulated by Proteins Coordinating Deubiquitination and Acetylation-Driven Ubiquitination
- (2010) Z. Du et al. Science Signaling
- Combination of novel proteasome inhibitor NPI-0052 and lenalidomide trigger in vitro and in vivo synergistic cytotoxicity in multiple myeloma
- (2009) D. Chauhan et al. BLOOD
- Functional Interaction of Plasmacytoid Dendritic Cells with Multiple Myeloma Cells: A Therapeutic Target
- (2009) Dharminder Chauhan et al. CANCER CELL
- Differential repetitive DNA methylation in multiple myeloma molecular subgroups
- (2009) V. Bollati et al. CARCINOGENESIS
- Pharmacological Modulation of Nitric Oxide Release: New Pharmacological Perspectives, Potential Benefits and Risks
- (2009) R. Scatena et al. CURRENT MEDICINAL CHEMISTRY
- TGFβR2aberrant methylation is a potential prognostic marker and therapeutic target in multiple myeloma
- (2009) Fabrício de Carvalho et al. INTERNATIONAL JOURNAL OF CANCER
- Epigenetic Cross-Talk between DNA Methylation and Histone Modifications in Human Cancers
- (2009) Yutaka Kondo YONSEI MEDICAL JOURNAL
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