Review
Biology
Wenlong Du, Guojun Shi, Chun-Min Shan, Zhiming Li, Bing Zhu, Songtao Jia, Qing Li, Zhiguo Zhang
Summary: This review summarizes the recent advances in the molecular mechanisms of epigenetic inheritance, discusses the potential impacts on normal development and diseases, and outlines future research directions in this field.
SCIENCE CHINA-LIFE SCIENCES
(2022)
Review
Plant Sciences
Kajal Samantara, Aalok Shiv, Lorenna Lopes de Sousa, Karansher Singh Sandhu, Parichita Priyadarshini, Sourav Ranjan Mohapatra
Summary: Epigenetics is an important mechanism that can help plants cope with various stressors by altering gene expression without involving changes in DNA sequences. It provides diversity to aid plants in responding to the impacts of climate change.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2021)
Review
Cell Biology
Hao Song, Juanli Chen, Jin Huang, Peng Sun, Yanming Liu, Li Xu, Chuanfei Wei, Xin Mu, Xianjie Lu, Wei Wang, Nan Zhang, Miwei Shang, Mei Mo, Wei Zhang, Hui Zhao, Fabin Han
Summary: Parkinson's disease (PD) is a common neurodegenerative disorder caused by genetic, epigenetic, and environmental factors. Recent advance in genomics and epigenetics have revealed epigenetic mechanisms in PD. These epigenetic modifications include DNA methylation, post-translational histone modifications, chromatin remodeling, and RNA-based mechanisms, which regulate cellular functions in almost all cells. Epigenetic alterations are involved in multiple aspects of neuronal development and neurodegeneration in PD.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Multidisciplinary Sciences
Wanqi Huang, Zhengwei Yuan, Hui Gu
Summary: Neural tube defects (NTDs) are a group of malformations caused by abnormal neural tube closure during early embryogenesis, with epigenetic changes playing an important role in NTD formation. Advances in epigenomic technologies enable the study of NTDs and uncover potential effects of candidate genes on NTD pathogenesis.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Review
Nanoscience & Nanotechnology
Qinglin Sun, Tianyu Li, Yang Yu, Yang Li, Zhiwei Sun, Junchao Duan
Summary: The toxicological effects of nanomaterials on health and the environment are gradually attracting attention due to the epigenetic alterations they cause, including DNA methylation, noncoding RNA expression, and histone modifications. These alterations can contribute to the onset and development of various diseases and serve as potential biomarkers for early diagnosis and prevention.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2022)
Review
Chemistry, Medicinal
Pia Loren, Nicolas Saavedra, Kathleen Saavedra, Tomas Zambrano, Patricia Moriel, Luis A. Salazar
Summary: Cisplatin, an antineoplastic drug, is most notably known for its nephrotoxicity among various side effects. Recent research shows that epigenetic regulation plays a key role in cisplatin-induced nephrotoxicity by altering different signaling pathways leading to cell death. Despite the ongoing development in this field, it offers new strategies for the diagnosis and treatment of diseases.
Review
Genetics & Heredity
Yuzhu Chen, Yumiao Sun, Xiangyu Xue, Huanzhi Ma
Summary: Epigenetic modification refers to the alteration of genetic expression, which can be inherited without changes in the DNA sequence. Osteoporosis is a metabolic disorder characterized by decreased bone density and increased risk of fractures. Recent research has shown that epigenetic mechanisms play a significant role in the development and progression of osteoporosis. This dissertation explores the progress in understanding epigenetic mechanisms, their regulation of bone metabolism, and their implications for the treatment of bone-related diseases.
FRONTIERS IN GENETICS
(2023)
Review
Biochemistry & Molecular Biology
Futaba Inoue, Kenbun Sone, Yusuke Toyohara, Yu Takahashi, Asako Kukita, Aki Hara, Ayumi Taguchi, Michihiro Tanikawa, Tetsushi Tsuruga, Yutaka Osuga
Summary: Epigenetic changes play a crucial role in endometrial cancer, including DNA methylation and histone modification. There are currently inhibitors targeting epigenetic regulators in preclinical studies and clinical trials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Matin Miryeganeh
Summary: Senescence is a major developmental transition in plants that involves gene reprogramming and multilevel regulation. Transcription factors and epigenetic mechanisms play crucial roles in senescence-related genes, in addition to genetic reprogramming.
Review
Biochemistry & Molecular Biology
Yinglu Li, Xiao Chen, Chao Lu
Summary: Methylation of CpG dinucleotides and histone residues plays a crucial role in genome regulation; there is a strong correlation between DNA and histone methylation; complex molecular crosstalk exists between DNA and histone methylation.
Article
Biochemistry & Molecular Biology
Sreepoorna Pramodh, Ritu Raina, Arif Hussain, Sali Abubaker Bagabir, Shafiul Haque, Syed Tasleem Raza, Mohammad Rehan Ajmal, Shalini Behl, Deepika Bhagavatula
Summary: This study analyzed the epigenetic modulatory behavior of luteolin on HeLa cells and found that luteolin can inhibit migration and colony formation in HeLa cells. It can also reactivate silenced tumor suppressor genes by modulating DNA methylation, enzyme activity, and global DNA methylation. Therefore, luteolin-targeted epigenetic alterations provide a potential approach for cancer prevention and intervention.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Ophthalmology
Monica Lamas
Summary: The eye undergoes structural and functional changes with aging, and epigenetic modifications play a crucial role in unraveling the molecular events responsible for these changes. Recent evidence suggests that DNA methylation, histone modification, and non-coding RNAs are closely associated with age-related alterations in gene expression and cell function in various components of the eye. Furthermore, epigenetic-based experimental therapies show potential for treating pathological conditions in the aging eye.
EXPERIMENTAL EYE RESEARCH
(2023)
Review
Chemistry, Medicinal
Amir Ajoolabady, Hamid Aslkhodapasandhokmabad, Yuan Zhou, Jun Ren
Summary: This article discusses the pathogenesis of alcohol-related liver disease (ARLD) and alcoholic liver disease (ALD), with a focus on the role of epigenetic factors in the development of liver disorders. Through cellular and animal model studies, the alcohol-induced epigenetic modifications (AIEM) and their relationship with liver diseases are explored, and epigenetics-based therapeutic options for managing ARLD and ALD are proposed.
MEDICINAL RESEARCH REVIEWS
(2022)
Review
Biochemistry & Molecular Biology
Yuexuan Wang, Yu Han, Yuzhen Jin, Qiang He, Zhicheng Wang
Summary: This study discusses the pathogenesis of cancer and the impact of radiotherapy on cancer. It has been found that epigenetic modification plays an important role in the occurrence and development of cancer. Radiation therapy affects the epigenetic modifications of DNA, chromatin, etc., which in turn affects the treatment outcomes. Therefore, studying the interaction between radiotherapy and epigenetic modifications can help us better understand cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Hirotomo Takatsuka, Atsushi Shibata, Masaaki Umeda
Summary: Plant DNA is vulnerable to environmental stressors, and chromatin plays a crucial role in protecting DNA by altering its structure. Changes in chromatin modifications, regulation of gene expression, and the physical barrier function of condensed chromatin are key mechanisms for plants to maintain genome integrity under genotoxic stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)