Article
Biochemistry & Molecular Biology
Leonid O. Bryzgalov, Elena E. Korbolina, Tatiana I. Merkulova
Summary: Alzheimer's disease is a common type of dementia with a significant genetic component. This study aims to identify non-coding regulatory SNPs that affect the epigenetic mechanisms in AD using a multi-omics approach. By integrating AD patient and control data, rSNPs with allele-specific features in histone modification and gene expression profiles were identified. Evaluation: 8 points
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Genetics & Heredity
Ines Orsolic, Arnaud Carrier, Manel Esteller
Summary: Cancer was once believed to be solely genetic, but now it is known that dysregulated genetic and epigenetic mechanisms work together in cancer development. Recently, the epitranscriptome, which refers to chemical modifications of RNA molecules, has been found to play a role in regulating RNA function. Specific enzymes responsible for these modifications, known as RMPs, are being investigated for their potential as therapeutic targets or diagnostic markers in cancer. The study of epitranscriptomics has revealed the critical role of RNA modifications in cellular pathways and their potential importance in cancer treatment.
TRENDS IN GENETICS
(2023)
Article
Plant Sciences
Farzaneh Darigh, Alireza Iranbakhsh, Zahra Oraghi Ardebili, Mostafa Ebadi, Halimeh Hassanpour
Summary: In vitro plant culture using simulated microgravity has been found to increase the production and concentration of cannabinoids in Cannabis indica callus cells, which has significant implications for meeting industrial demand for medicinal cannabis.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Review
Cell Biology
Domenica Scumaci, Qingfei Zheng
Summary: Histones undergo a variety of post-translational modifications that regulate cell fate. Accumulation of epigenetic alterations is a driving force behind cancer progression. Non-enzymatic covalent modifications of histones have been recently described, which are closely related to cellular metabolism and can impair chromatin structure. Cancer cells counteract the accumulation of these modifications by overexpressing eraser enzymes. This review explores these modifications and their corresponding eraser enzymes, and proposes targeting these enzymes as a strategy for personalized medicine.
CELL COMMUNICATION AND SIGNALING
(2023)
Editorial Material
Medicine, Research & Experimental
Jamie R. Johnston, Daniel F. Selgrade, Elizabeth M. McNally
Summary: Mutations in the LMNA gene are a common cause of adult-onset cardiomyopathy and heart failure, with a prenatal feature of impaired cardiomyocyte development and maturation identified in a Laminopathy model. Treatment of the LMNA H222P mouse model improved congenital cardiomyopathy and increased survival in utero, presenting a unique therapeutic strategy for cardiomyopathy.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Review
Genetics & Heredity
Tomoko Soga, Chuin Hau Teo, Ishwar Parhar
Summary: This article discusses the lasting impact of early-life social stress on mental and physical health, suggesting that early social stress may have epigenetic effects leading to complex mental disorders, especially depression. It emphasizes the interaction between early-life social stress and genetic variations in serotonin-related genes, such as the serotonin transporter gene, which play key roles in depression.
FRONTIERS IN GENETICS
(2021)
Review
Plant Sciences
Jie Liu, Meng Ke, Yuhan Sun, Shihui Niu, Wenli Zhang, Yun Li
Summary: Plant rejuvenation involves resetting gene expression patterns, chromatin remodeling, and histone modifications, resulting in the restoration of juvenile characteristics. The epigenetic mechanisms underlying this process are still in the early stages of study.
JOURNAL OF EXPERIMENTAL BOTANY
(2023)
Review
Biochemistry & Molecular Biology
Raushan Zh Karabaeva, Tamara A. Vochshenkova, Afshin Zare, Nazanin Jafari, Hanieh Baneshi, Nadiar Maratovich Mussin, Rustam Kuanyshbekovich Albayev, Asset Askerovich Kaliyev, Akmaral Baspakova, Amin Tamadon
Summary: This study reveals the critical role of genetic factors in arterial hypertension through in silico analysis, while identifying specific microRNAs with potential clinical applications.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Peripheral Vascular Disease
Deborah Ignacia D. Ona, Cecilia A. Jimeno, Gabriel V. Jasul, Ma. Lourdes E. Bunyi, Raymond Oliva, Lourdes Ella Gonzalez-Santos, Leilani B. Mercado-Asis, Vimar A. Luz, Aurelia G. Leus, Alejandro Bimbo F. Diaz, Marjorie I. Santos, Allan A. Belen, Dolores D. Bonzon, Jonnie Bote-Nunez, Roberta Maria N. Cawed-Mende, Arnel S. Chua, Anne Marie Joyce T. Javier, Dan Neftalie A. Juangco, Carmela Madrigal-Dy, Marlon B. Manicad, Juan Miguel Gil R. Ortiz, Christia S. Padolina, Maria Concepcion C. Sison, Ninfa J. Villanueva
Summary: Hypertension is a major cause of death and disability globally, particularly in low to middle income countries. In the Philippines, it remains a significant health issue with poor blood pressure control as a major cause. The collaboration of different societies led to the development of the 2020 Philippine Clinical Practice Guidelines for hypertension, aiming to provide evidence-based care and help healthcare professionals effectively manage hypertension patients.
JOURNAL OF CLINICAL HYPERTENSION
(2021)
Article
Multidisciplinary Sciences
Genta Nagae, Shogo Yamamoto, Masashi Fujita, Takanori Fujita, Aya Nonaka, Takayoshi Umeda, Shiro Fukuda, Kenji Tatsuno, Kazuhiro Maejima, Akimasa Hayashi, Sho Kurihara, Masato Kojima, Tomoro Hishiki, Kenichiro Watanabe, Kohmei Ida, Michihiro Yano, Yoko Hiyama, Yukichi Tanaka, Takeshi Inoue, Hiroki Ueda, Hidewaki Nakagawa, Hiroyuki Aburatani, Eiso Hiyama
Summary: The study conducted genomic and epigenomic profiling of 163 untreated pediatric liver tumors, suggesting upregulation of ASCL2 and methylation patterns of IGF2 promoters as drivers for hepatoblastoma carcinogenesis.
NATURE COMMUNICATIONS
(2021)
Review
Biotechnology & Applied Microbiology
Marta Pogribna, George Hammons
Summary: This review summarizes the current evidence of alterations in cytosine DNA methylation and histone modifications in response to nanomaterials and nanoparticles exposures, highlighting existing knowledge gaps regarding the role of epigenetic alterations in their toxicity. Additionally, it discusses the potential role of epigenetic changes as translational biomarkers for detecting adverse effects of nanomaterials and nanoparticles.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
Kathryn C. Allaway, Mariano I. Gabitto, Orly Wapinski, Giuseppe Saldi, Chen-Yu Wang, Rachel C. Bandler, Sherry Jingjing Wu, Richard Bonneau, Gord Fishell
Summary: The study reveals that cortical interneurons, such as parvalbumin- and somatostatin-positive cells, originate from common lineages but exhibit distinct anatomical and functional differences in adulthood. It also shows how developmental changes in transcription and chromatin structure enable these cells to acquire unique identities and specialized properties by adulthood.
Article
Pharmacology & Pharmacy
Fernanda Priviero
Summary: Cardiovascular diseases (CVD) are the leading cause of death in the United States, with hypertension as a major risk factor. Genetic and modifiable factors both play a role in hypertension, with stress, sleep deprivation, obesity, and sedentarism contributing to epigenetic modifications that lead to hypertension. On the other hand, physical exercise and healthier habits can induce beneficial epigenetic changes and help prevent the inheritance of hypertension. Adverse environments during pregnancy and early life also increase the risk of hypertension and CVD, while healthier habits during this period can improve cardiovascular health in future generations by countering fetal programming.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xianlian Chen, Cheng Liu, Pengfei Guo, Xiaoshuai Hao, Yongpeng Pan, Kai Zhang, Wusheng Liu, Lizhi Zhao, Wei Luo, Jianbo He, Yanzhu Su, Ting Jin, Fenfen Jiang, Si Wang, Fangdong Liu, Rongzhou Xie, Changgen Zhen, Wei Han, Guangnan Xing, Wubin Wang, Shancen Zhao, Yan Li, Junyi Gai
Summary: By studying chromosome segment substitution lines of wild soybean, the SW16.1 gene was identified as the major gene controlling seed weight in soybean. The GsSW16.1 allele in wild soybean had a negative effect on seed weight, while the GmSW16.1 allele in cultivated soybean had a positive effect. The study provides insights into the genetic basis of seed weight increase during soybean domestication.
JOURNAL OF INTEGRATIVE PLANT BIOLOGY
(2023)
Review
Endocrinology & Metabolism
Innocent Ogunmwonyi, Adewale Adebajo, Jeremy Mark Wilkinson
Summary: Nutritional rickets is a significant global health issue, characterized by bony deformities and an increased risk of life-threatening seizures due to hypocalcemia. Deficiency in dietary vitamin D is associated with the development of nutritional rickets in children and infants. Genetic and epigenetic factors may influence an individual's susceptibility to developing nutritional rickets.
FRONTIERS IN ENDOCRINOLOGY
(2022)