Discovery of decreased ferroptosis in male colorectal cancer patients with KRAS mutations

Ferroptosis in colorectal cancer: a future target?

(2023) Hong Yan et al.   BRITISH JOURNAL OF CANCER

Targeting ferroptosis to treat colorectal cancer

(2022) Hong Yan et al.   TRENDS IN CELL BIOLOGY

Immune landscape and prognostic immune-related genes in KRAS-mutant colorectal cancer patients

(2021) Jungang Liu et al.   Journal of Translational Medicine

The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer

(2021) Arafath K. Najumudeen et al.   NATURE GENETICS

Autophagy-dependent ferroptosis drives tumor-associated macrophage polarization via release and uptake of oncogenic KRAS protein

(2020) Enyong Dai et al.   Autophagy

Sex Differences in Colon Cancer Metabolism Reveal A Novel Subphenotype

(2020) Yuping Cai et al.   Scientific Reports

Cysteine Depletion, a Key Action to Challenge Cancer Cells to Ferroptotic Cell Death

(2020) Boutaina Daher et al.   Frontiers in Oncology

The emerging role of ferroptosis in inflammation

(2020) Yitian Sun et al.   BIOMEDICINE & PHARMACOTHERAPY

Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer

(2020) Léo Aubert et al.   Nature Communications

Cysteine as a Carbon Source, a Hot Spot in Cancer Cells Survival

(2020) Jacinta Serpa   Frontiers in Oncology

Plasma metabolites associated with colorectal cancer stage: findings from an international consortium

(2019) Anne J.M.R. Geijsen et al.   INTERNATIONAL JOURNAL OF CANCER

Regulators of the Transsulfuration Pathway

(2018) Juan I Sbodio et al.   BRITISH JOURNAL OF PHARMACOLOGY

Novel Allosteric Activators for Ferroptosis Regulator Glutathione Peroxidase 4

(2018) Cong Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

Role of GPX4 in ferroptosis and its pharmacological implication

(2018) Tobias M. Seibt et al.   FREE RADICAL BIOLOGY AND MEDICINE

Understanding the role of primary tumour localisation in colorectal cancer treatment and outcomes

(2017) Sebastian Stintzing et al.   EUROPEAN JOURNAL OF CANCER

UALCAN: A Portal for Facilitating Tumor Subgroup Gene Expression and Survival Analyses

(2017) Darshan S. Chandrashekar et al.   NEOPLASIA

Iron Uptake via DMT1 Integrates Cell Cycle with JAK-STAT3 Signaling to Promote Colorectal Tumorigenesis

(2016) Xiang Xue et al.   Cell Metabolism

Arachidonate 12/15-Lipoxygenase–Induced Inflammation and Oxidative Stress Are Involved in the Development of Diabetic Cardiomyopathy

(2014) Hirofumi Suzuki et al.   DIABETES

Nrf2- and ATF4-Dependent Upregulation of xCT Modulates the Sensitivity of T24 Bladder Carcinoma Cells to Proteasome Inhibition

(2014) P. Ye et al.   MOLECULAR AND CELLULAR BIOLOGY

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

(2014) Scott J Dixon et al.   eLife

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

(2013) Jaekyoung Son et al.   NATURE

Hypoxia-Inducible Factor-2  Activation Promotes Colorectal Cancer Progression by Dysregulating Iron Homeostasis

(2012) X. Xue et al.   CANCER RESEARCH

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Biogenesis of iron-sulfur clusters in mammalian cells: new insights and relevance to human disease

(2012) T. A. Rouault   Disease Models & Mechanisms

Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells

(2012) Oliver D. K. Maddocks et al.   NATURE

Frequent Epigenetic Silencing of the Folate-Metabolising Gene Cystathionine-Beta-Synthase in Gastrointestinal Cancer

(2012) Hong Zhao et al.   PLoS One

The transsulfuration pathway: a source of cysteine for glutathione in astrocytes

(2011) Gethin J. McBean   AMINO ACIDS

The oxidative stress-inducible cystine/glutamate antiporter, system x c − : cystine supplier and beyond

(2011) Marcus Conrad et al.   AMINO ACIDS