Role of the Gut-Brain Axis in the Shared Genetic Etiology Between Gastrointestinal Tract Diseases and Psychiatric Disorders

Cross-tissue transcriptome-wide association studies identify susceptibility genes shared between schizophrenia and inflammatory bowel disease

(2022) Florian Uellendahl-Werth et al.   Communications Biology

Human gut bacteria produce ΤΗ17-modulating bile acid metabolites

(2022) Donggi Paik et al.   NATURE

Parental inflammatory bowel disease and autism in children

(2022) Aws Sadik et al.   NATURE MEDICINE

An Atlas of Genetic Correlations and Genetically Informed Associations Linking Psychiatric and Immune-Related Phenotypes

(2022) Daniel S. Tylee et al.   JAMA Psychiatry

Estimation of the bidirectional relationship between schizophrenia and inflammatory bowel disease using the mendelian randomization approach

(2022) Li Qian et al.   npj Schizophrenia

Th17 Cells in Inflammatory Bowel Disease: Cytokines, Plasticity, and Therapies

(2021) Junjun Zhao et al.   Journal of Immunology Research

E-MAGMA: an eQTL-informed method to identify risk genes using genome-wide association study summary statistics

(2021) Zachary F Gerring et al.   BIOINFORMATICS

A fast and efficient colocalization algorithm for identifying shared genetic risk factors across multiple traits

(2021) Christopher N. Foley et al.   Nature Communications

GWAS of peptic ulcer disease implicates Helicobacter pylori infection, other gastrointestinal disorders and depression

(2021) Yeda Wu et al.   Nature Communications

Prevalence of symptoms of anxiety and depression in patients with inflammatory bowel disease: a systematic review and meta-analysis

(2021) Brigida Barberio et al.   Lancet Gastroenterology & Hepatology

Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology

(2021) Niamh Mullins et al.   NATURE GENETICS

A large multiethnic GWAS meta-analysis of cataract identifies new risk loci and sex-specific effects

(2021) Hélène Choquet et al.   Nature Communications

Depression and Inflammatory Bowel Disease: A Bidirectional Two-sample Mendelian Randomization Study

(2021) Jiao Luo et al.   Journal of Crohns & Colitis

Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders

(2021) Chris Eijsbouts et al.   NATURE GENETICS

Simultaneous estimation of bi-directional causal effects and heritable confounding from GWAS summary statistics

(2021) Liza Darrous et al.   Nature Communications

A computational tool (H-MAGMA) for improved prediction of brain-disorder risk genes by incorporating brain chromatin interaction profiles

(2020) Nancy Y. A. Sey et al.   NATURE NEUROSCIENCE

Shared genetic susceptibilities for irritable bowel syndrome and depressive disorder in Chinese patients uncovered by pooled whole-exome sequencing

(2020) Shiwei Zhu et al.   Journal of Advanced Research

High-definition likelihood inference of genetic correlations across human complex traits

(2020) Zheng Ning et al.   NATURE GENETICS

Genome-wide association meta-analysis for early age-related macular degeneration highlights novel loci and insights for advanced disease

(2020) Thomas W. Winkler et al.   BMC Medical Genomics

A unified framework for joint-tissue transcriptome-wide association and Mendelian randomization analysis

(2020) Dan Zhou et al.   NATURE GENETICS

PLEIO: a method to map and interpret pleiotropic loci with GWAS summary statistics

(2020) Cue Hyunkyu Lee et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mouse Genome Database (MGD): Knowledgebase for mouse–human comparative biology

(2020) Judith A Blake et al.   NUCLEIC ACIDS RESEARCH

A powerful method for pleiotropic analysis under composite null hypothesis identifies novel shared loci between Type 2 Diabetes and Prostate Cancer

(2020) Debashree Ray et al.   PLoS Genetics

Psychological comorbidity in gastrointestinal diseases: Update on the brain-gut-microbiome axis

(2020) Hannibal Person et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Bivariate genome-wide association analyses of the broad depression phenotype combined with major depressive disorder, bipolar disorder or schizophrenia reveal eight novel genetic loci for depression

(2019) Azmeraw T. Amare et al.   MOLECULAR PSYCHIATRY

Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions

(2019) David M. Howard et al.   NATURE NEUROSCIENCE

Impact of microbiota on central nervous system and neurological diseases: the gut-brain axis

(2019) Qianquan Ma et al.   Journal of Neuroinflammation

deTS: tissue-specific enrichment analysis to decode tissue specificity

(2019) Guangsheng Pei et al.   BIOINFORMATICS

Cross-disorder analysis of schizophrenia and 19 immune-mediated diseases identifies shared genetic risk

(2019) Jennie G Pouget et al.   HUMAN MOLECULAR GENETICS

Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa

(2019) Hunna J. Watson et al.   NATURE GENETICS

A global overview of pleiotropy and genetic architecture in complex traits

(2019) Kyoko Watanabe et al.   NATURE GENETICS

The Microbiota-Gut-Brain Axis

(2019) John F. Cryan et al.   PHYSIOLOGICAL REVIEWS

International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci

(2019) Caroline M. Nievergelt et al.   Nature Communications

Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases

(2018) Marie Verbanck et al.   NATURE GENETICS

Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection

(2018) Antonio F. Pardiñas et al.   NATURE GENETICS

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(2018)   GENETIC EPIDEMIOLOGY

Unknown

(2018)   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

The UK Biobank resource with deep phenotyping and genomic data

(2018) Clare Bycroft et al.   NATURE

Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder

(2018) Ditte Demontis et al.   NATURE GENETICS

Genetic Correlation Profile of Schizophrenia Mirrors Epidemiological Results and Suggests Link Between Polygenic and Rare Variant (22q11.2) Cases of Schizophrenia

(2017) Laramie E Duncan et al.   SCHIZOPHRENIA BULLETIN

Functional mapping and annotation of genetic associations with FUMA

(2017) Kyoko Watanabe et al.   Nature Communications

Statistical methods to detect pleiotropy in human complex traits

(2017) Sophie Hackinger et al.   Open Biology

Pervasive pleiotropy between psychiatric disorders and immune disorders revealed by integrative analysis of multiple GWAS

(2015) Qian Wang et al.   HUMAN GENETICS

Gut/brain axis and the microbiota

(2015) Emeran A. Mayer et al.   JOURNAL OF CLINICAL INVESTIGATION

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

(2015) Brendan K Bulik-Sullivan et al.   NATURE GENETICS

MAGMA: Generalized Gene-Set Analysis of GWAS Data

(2015) Christiaan A. de Leeuw et al.   PLoS Computational Biology

Targeting Th17 cells in autoimmune diseases

(2014) Jianfei Yang et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

GPA: A Statistical Approach to Prioritizing GWAS Results by Integrating Pleiotropy and Annotation

(2014) Dongjun Chung et al.   PLoS Genetics

Bayesian Test for Colocalisation between Pairs of Genetic Association Studies Using Summary Statistics

(2014) Claudia Giambartolomei et al.   PLoS Genetics

The Genotype-Tissue Expression (GTEx) project

(2013) John Lonsdale et al.   NATURE GENETICS

Pleiotropy in complex traits: challenges and strategies

(2013) Nadia Solovieff et al.   NATURE REVIEWS GENETICS

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

(2012) Guangchuang Yu et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Abundant Pleiotropy in Human Complex Diseases and Traits

(2011) Shanya Sivakumaran et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The Psychiatric GWAS Consortium: Big Science Comes to Psychiatry

(2010) Patrick F. Sullivan   NEURON

Differential regulation of interleukin 17 and interferon   production in inflammatory bowel disease

(2009) L. Rovedatti et al.   GUT

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(2008)   Annual Review of Immunology