Article
Oncology
Changhee Park, Kyeonghun Jeong, Joon-Hyeong Park, Sohee Jung, Jeong Mo Bae, Kwangsoo Kim, Chan-Young Ock, Miso Kim, Bhumsuk Keam, Tae Min Kim, Yoon Kyung Jeon, Se-Hoon Lee, Ju-Seog Lee, Dong-Wan Kim, Gyeong Hoon Kang, Doo Hyun Chung, Dae Seog Heo
Summary: The study demonstrated a negative correlation between overall methylation aberrancy and tumor immunogenicity, indicating the importance of methylation aberrancy for tumors to evade immune surveillance. This highlights the need for further development of methylation biomarkers in cancer research.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Oncology
Zheng Li, Yaming Li, Xiaolong Wang, Qifeng Yang
Summary: The study identified PPP2R2B as a strong tumor suppressor in TNBC, with downregulated expression in TNBC tissues compared to normal breast tissues. Low PPP2R2B expression was associated with shorter survival time and could play a key role in breast cancer initiation and progression. PPP2R2B was also found to be related to specific immune cells and immune inhibitor genes.
CANCER CELL INTERNATIONAL
(2021)
Article
Multidisciplinary Sciences
De-Chen Lin
Summary: Esophageal cancers exhibit distinct manifestations among and within patients, making precise diagnosis, prognosis, and patient care complicated. New genomic and epigenomic research identifies novel mechanisms underlying both inter- and intra-tumoral heterogeneity in esophageal cancer, with significant implications in biology and translation.
NATURE COMMUNICATIONS
(2023)
Review
Medicine, General & Internal
Kedar Kirtane, Maie St. John, Harry Fuentes-Bayne, Sandip P. P. Patel, Armen Mardiros, Han Xu, Eric W. W. Ng, William Y. Y. Go, Deborah J. J. Wong, John B. B. Sunwoo, John S. S. Welch
Summary: Head and neck squamous cell cancers (HNSCCs) are a diverse group of tumors associated with risk factors such as smoking, alcohol, age, sex, mutations, and viral infections. They exhibit high mutation burden and loss of tumor suppressor gene function, with implications for immune response and clinical outcomes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Jayesh Kumar Tiwari, Shloka Negi, Manju Kashyap, Sheikh Nizamuddin, Amar Singh, Arun Khattri
Summary: This article analyzes the pan-cancer TIME of EMT, showing that EMT-high tumors have a highly immunosuppressive TIME compared to EMT-low tumors. The distinctive features of EMT-high tumors include the enrichment of tumor-associated macrophages, overexpression of immune checkpoint molecules, upregulation of immune inhibitory cytokines TGFB1 and IL10, and enrichment of inflammatory and exhausted CD8+ T-cell signatures. This study suggests the importance of analyzing and targeting the TIME regulators for anticancer immunotherapy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Genetics & Heredity
Sabine Muth, Annekatrin Klaric, Markus Radsak, Hansjoerg Schild, Hans Christian Probst
Summary: Treg-expressed CD27 maintains DC tolerogenic in steady state and limits anti-tumor immunity; Ablation of Treg-expressed CD27 synergizes with PD-1 blockade to improve CTL-mediated tumor control.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Article
Immunology
Jacek Skarbinski, Joshua R. Nugent, Mariah S. Wood, Liyan Liu, Teal Bullick, Jeffrey M. Schapiro, Phacharee Arunleung, Christina Morales, Laura B. Amsden, Crystal A. Hsiao, Debra A. Wadford, Shua J. Chai, Arthur Reingold, Stacia K. Wyman
Summary: Genomic variation within the Delta variant of SARS-CoV-2 was weakly associated with breakthrough infection, but several potential nonlineage defining mutations were identified that might contribute to immune evasion by SARS-CoV-2.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Oncology
Minde Li, Shaoyang Li, Lin Zhou, Le Yang, Xiao Wu, Bin Tang, Shenhao Xie, Linchun Fang, Suyue Zheng, Tao Hong
Summary: The study shows that MMP14 expression is closely related to the prognosis of various cancers and tumor immune invasion, and has important effects on pan-cancer MMR, MSI, TMB, DNA methylation, and immune checkpoint genes.
FRONTIERS IN ONCOLOGY
(2021)
Article
Genetics & Heredity
Xinwei Li, Yongfei Fan, Yue Zhang, Yanyan Wang, Menglin Zhao, Mingyue Tang, Huiyuan Li, Jiaqi Mi, Zhijun Geng, Zishu Wang, Fang Su
Summary: This study analyzed the oncological features of CHSY3 in stomach adenocarcinoma (STAD) and revealed that CHSY3 can be a biomarker of poor prognosis and mediates the immune-evasion status in STAD.
FRONTIERS IN GENETICS
(2022)
Article
Immunology
Nicole A. P. Lieberman, Carlos C. Avendano, Shah A. K. Mohamed Bakhash, Ethan Nunley, Hong Xie, Lorenzo Giacani, Anna Berzkalns, Olusegun O. Soge, Tara B. Reid, Matthew R. Golden, Alexander L. Greninger
Summary: This study investigates the genomic epidemiology of Treponema pallidum in American metropolitan areas and identifies the significance of different strains in the transmission and treatment of syphilis.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Markus Kellner, Bettina von Neubeck, Bastian Czogalla, Regina Feederle, Binje Vick, Irmela Jeremias, Reinhard Zeidler
Summary: CD73 inhibition, particularly with the antibody 22E6, shows great potential for cancer therapy by reducing tumor growth and interfering with chemoresistance. However, complete blocking of CD73 activity may have adverse effects.
Article
Oncology
Zi-jun Xu, Ye Jin, Xin-long Zhang, Pei-hui Xia, Xiang-mei Wen, Ji-chun Ma, Jiang Lin, Jun Qian
Summary: This study comprehensively investigated the expression patterns and clinical significance of CD300s in cancers. The results showed that high CD300A-CD300LF expression was associated with poor outcome in AML patients and could predict response to AML immunotherapy.
Article
Microbiology
Matteo Bulati, Rosalia Busa, Claudia Carcione, Gioacchin Iannolo, Giuseppina Di Mento, Nicola Cuscino, Roberto Di Gesu, Antonio Palumbo Piccionello, Silvestre Buscemi, Anna Paola Carreca, Floriana Barbera, Francesco Monaco, Francesca Cardinale, Pier Giulio Conaldi, Bruno Douradinha
Summary: Multidrug resistant Klebsiella pneumoniae with LPS O2afg serotypes are able to evade the initial inflammatory immune response and systematically spread inside the host, resulting in various pathologies associated with this bacterium.
Article
Surgery
Yifan Cao, Hongyong He, Ruochen Li, Xin Liu, Yifan Chen, Yangyang Qi, Kuan Yu, Jieti Wang, Chao Lin, Hao Liu, Heng Zhang, He Li, Lingli Chen, Peipei Zhang, Zhenbin Shen, Hua Huang, Yihong Sun, Weijuan Zhang, Jing Qin, Jiejie Xu
Summary: This study revealed the clinical significance of LAP in predicting survival outcomes and chemotherapeutic responsiveness in gastric cancer. High LAP expression was associated with poor overall survival and inferior response to adjuvant chemotherapy. LAP was also associated with an immunoevasive tumor microenvironment and dysfunctional CD8(+) T cell infiltration.
Article
Surgery
Hongyu Zhang, Ruochen Li, Yifan Cao, Yun Gu, Chao Lin, Xin Liu, Kunpeng Lv, Xudong He, Hanji Fang, Kaifeng Jin, Yuchao Fei, Yifan Chen, Jieti Wang, Hao Liu, He Li, Heng Zhang, Hongyong He, Weijuan Zhang
Summary: This study revealed the clinical significance of IL-10(+) tumor-associated macrophages (TAMs) in gastric cancer. It showed that high IL-10(+) TAM infiltration was associated with poor prognosis and inferior therapeutic responsiveness to fluorouracil-based adjuvant chemotherapy. IL-10(+) TAMs drove an immunoevasive tumor microenvironment, indicating their potential as a target for immunotherapeutic approach in gastric cancer.