Article
Cell Biology
Lina Sun, Weiwei Zhang, Ruiqi Ye, Lei Liu, Lili Jiang, Chao Xi
Summary: The study evaluated the effects of catalpol on exercise-mediated PTSD therapeutic effects, finding that it enhanced the reduction in response to dangerous cues, as well as the antidepressant and cognitive protection effects in mice. Through immunofluorescence, it was discovered that catalpol promoted exercise-induced hippocampal neurogenesis. Blocking neurogenesis compromised the effects of catalpol on exercise-induced improvements in environmental hyper-response, antidepressant effects, and cognitive protection. These findings suggest that hippocampal neurogenesis is crucial for catalpol to enhance exercise-mediated brain functional improvements in a PTSD model.
Article
Neurosciences
Rodrigo Moraga-Amaro, Raul Diaz-Galarce, Juan P. Donoso-Ramos, Valentina Ugalde, Sergio Linsambarth, Janine Doorduin, Erik FJ. de Vries, Estibaliz Ampuero, Francisca Pena, Rodrigo Pacheco, Ursula Wyneken, Jimmy Stehberg
Summary: This study evaluated the effects of prenatal fluoxetine exposure on memory and emotional behavior of rat offspring. Results showed that male rats exposed to fluoxetine during gestation displayed memory impairments and increased anxiety- and depressive-like symptoms in adulthood.
Article
Neurosciences
Amin Orumiyehei, Kayvan Khoramipour, Maryam Hossein Rezaei, Elham Madadizadeh, Manzumeh Shamsi Meymandi, Fatemeh Mohammadi, Mohsen Chamanara, Hamideh Bashiri, Katsuhiko Suzuki
Summary: High-intensity interval training (HIIT) improves anxiety-like behaviors in rats with type 2 diabetes through hippocampal molecular changes, but does not significantly affect cognitive function.
Article
Geriatrics & Gerontology
Kirolos Ibrahim, Ilana J. Bennett
Summary: This study found that hippocampal microstructure uniquely contributes to age-related differences in episodic memory and suggests that volume and diffusion capture distinct neurobiological properties of hippocampal gray matter.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Neurosciences
Minghua Fan, Yongqing Liu, Yongfeng Shang, Yanxue Xue, Jing Liang, Zhuo Huang
Summary: Through experimental research, it is found that JADE2 plays a key role in regulating synaptic plasticity and memory formation in hippocampal neurons, and it regulates synaptic function by transcriptional activation of Rac1.
BIOLOGICAL PSYCHIATRY
(2022)
Article
Nutrition & Dietetics
Wei Xiong, Rongzi Li, Boying Li, Xifan Wang, Huihui Wang, Yanan Sun, Xiaoyu Wang, Yixuan Li, Fazheng Ren
Summary: Memory impairment is a characteristic of brain aging, and enhancing neurogenesis is a potential method for mitigating it. Nobiletin (NOB), a natural flavonoid derived from citrus peels, was found to attenuate memory impairment and restore hippocampal neurogenesis in aging mice. Furthermore, NOB inhibited inflammation and improved viability and differential ability of cells. Overall, NOB is a potential candidate for improving brain function by enhancing neurogenesis.
Review
Neurosciences
Jesse D. Cushman, Michael R. Drew, Franklin B. Krasne
Summary: The primary function of juvenile and adult hippocampal neurogenesis appears to be allowing behavioral experience to shape connectivity in the dentate gyrus and optimize hippocampal circuits for future learning. This environmental sculpting reduces overlap among memory representations, provides more information, and allows for more memories to be stored accurately. The decline of neurogenesis prior to adulthood may be explained by this prospective function of sculpting hippocampal circuits.
PROGRESS IN NEUROBIOLOGY
(2021)
Article
Biology
Ming-Yi Chou, Xuhui Cao, Kuan-Chu Hou, Meng-Han Tsai, Chih-Yu Lee, Meng-Fai Kuo, Vin-Cent Wu, Hsin-Yi Huang, Schahram Akbarian, Sheng-Kai Chang, Chung-Yi Hu, Shu-Wha Lin, Hsien-Sung Huang
Summary: Knockout of Mir125b-2 in mice leads to defects in hippocampus-related behaviors and affects hippocampal expression of Grin2a and NMDAR-mediated currents. Paternal expression of MIR125B2 is observed in the human brain. Mir125b-2 knockout mice show impaired learning, memory, and anxiety, and altered excitability and synaptic transmission in hippocampal granule cells. This study reveals the functional mechanisms of a species-specific imprinted microRNA in the brain.
COMMUNICATIONS BIOLOGY
(2023)
Article
Neurosciences
Adam J. Lundquist, Tyler J. Gallagher, Giselle M. Petzinger, Michael W. Jakowec
Summary: The study found that l-Lactate can promote the expression of neurotrophic genes in astrocytes and increase the morphological complexity of astrocytes in the striatum, suggesting a potential link between peripheral l-Lactate production, intensive exercise, and neuroplasticity in specific brain regions through astrocytic function. However, the effects of peripheral l-Lactate on synaptogenesis or motor behavior were not demonstrated, possibly due to insufficient levels and delivery of l-Lactate through regional cerebral blood flow in the striatum.
JOURNAL OF NEUROSCIENCE RESEARCH
(2021)
Article
Neurosciences
Desiree R. Seib, Oren Princz-Lebel, Erin R. Chahley, Stan B. Floresco, Jason S. Snyder
Summary: A fundamental trait of depression is low motivation. This study used a rat model to investigate the role of adult hippocampal neurogenesis in motivation and found that reducing neurogenesis decreased response vigor to obtain rewards, providing further insights into how neurogenesis shapes depression.
Article
Clinical Neurology
Emrah Duezel, Gabriel Ziegler, David Berron, Anne Maass, Hartmut Schuetze, Arturo Cardenas-Blanco, Wenzel Glanz, Coraline Metzger, Laura Dobisch, Martin Reuter, Annika Spottke, Frederic Brosseron, Klaus Fliessbach, Michael T. Heneka, Christoph Laske, Oliver Peters, Josef Priller, Eike Jakob Spruth, Alfredo Ramirez, Oliver Speck, Anja Schneider, Stefan Teipel, Ingo Kilimann, Wiltfang Jens, Bjoern-Hendrik Schott, Lukas Preis, Daria Gref, Franziska Maier, Matthias H. Munk, Nina Roy, Tomasso Ballarini, Renat Yakupov, John Dylan Haynes, Peter Dechent, Klaus Scheffler, Michael Wagner, Frank Jessen
Summary: This study investigated whether the impact of tau-pathology on memory performance and hippocampal/medial temporal memory function depends on the presence of amyloid pathology. The results showed a linear relationship between amyloid pathology, tau pathology, hippocampal dysfunction, and memory impairment.
Article
Biochemistry & Molecular Biology
Jia-He Zhang, Takashi Tasaki, Manabu Tsukamoto, Ke-Yong Wang, Kin-ya Kubo, Kagaku Azuma
Summary: The deletion of Wnt10a leads to decreased neurogenesis, impaired synaptic function, and neuroinflammation in the hippocampus, ultimately resulting in hippocampal neurodegeneration and memory deficits.
Article
Biology
Raly James Perez Custodio, Hee Jin Kim, Jiyeon Kim, Darlene Mae Ortiz, Mikyung Kim, Danilo Buctot, Leandro Val Sayson, Hyun Jun Lee, Bung-Nyun Kim, Eugene C. C. Yi, Jae Hoon Cheong
Summary: Proteomics analysis revealed that Wnt signaling may regulate the behavioral impairments in THRSP-overexpressing mice in the hippocampal dentate gyri. Children with ADHD-PI often suffer from impaired executive function, temporal processing, and visuospatial memory, which are controlled by the hippocampus. However, the specific genes/proteins involved and how they influence ADHD behavior in the hippocampus are still not well understood. Proteomics and network analysis showed dysregulated Wnt signaling affecting hippocampal dentate gyrus cell proliferation and neural stem cell activity.
COMMUNICATIONS BIOLOGY
(2023)
Article
Neurosciences
Debora da Silva Bandeira Rego, Clivandir S. Silva, Luiz Eugenio A. M. Mello, Ana Teresa Figueiredo Stochero Leslie
Summary: This study found that preemptive fentanyl administration in neonatal rats reduced the impact of a nociceptive stimulus on hippocampal neurogenesis, behavior, and learning. However, this effect did not persist during adolescence.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Critical Care Medicine
Kate Karelina, Katarina Schneiderman, Sarthak Shah, Julie Fitzgerald, Ruth Velazquez Cruz, Robin Oliverio, Bailey Whitehead, Jingzhen Yang, Zachary M. Weil
Summary: Despite the common practice of prescribed rest after traumatic brain injury (TBI), research shows little to no benefit of it on patient outcomes, with prolonged rest potentially interfering with patient well-being. In contrast, animal models consistently indicate that exercise is neuroprotective and promotes recovery after brain injury, suggesting carefully titrated physical activity may be a safe and effective approach to promoting recovery.
JOURNAL OF NEUROTRAUMA
(2021)