Natural Product Skatole Ameliorates Lipotoxicity-Induced Multiple Hepatic Damage under Hyperlipidemic Conditions in Hepatocytes

The Mechanism Underlying the Influence of Indole-3-Propionic Acid: A Relevance to Metabolic Disorders

(2022) Binbin Zhang et al.   Frontiers in Endocrinology

Pathogenesis and Therapeutic Strategies Related to Non-Alcoholic Fatty Liver Disease

(2022) Tieshan Teng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Alisol B Alleviates Hepatocyte Lipid Accumulation and Lipotoxicity via Regulating RARα-PPARγ-CD36 Cascade and Attenuates Non-Alcoholic Steatohepatitis in Mice

(2022) Zhuohui Zhao et al.   Nutrients

The prevalence and incidence of NAFLD worldwide: a systematic review and meta-analysis

(2022) Kiarash Riazi et al.   Lancet Gastroenterology & Hepatology

Indolepropionic Acid, a Gut Bacteria-Produced Tryptophan Metabolite and the Risk of Type 2 Diabetes and Non-Alcoholic Fatty Liver Disease

(2022) Ratika Sehgal et al.   Nutrients

Role of Oxidative Stress in the Pathogenesis of Non-Alcoholic Fatty Liver Disease: Implications for Prevention and Therapy

(2021) Johanna C. Arroyave-Ospina et al.   Antioxidants

NAFLD, Insulin Resistance, and Diabetes Mellitus Type 2

(2021) Marinko Marušić et al.   Canadian Journal of Gastroenterology and Hepatology

Somatization in patients with predominant diarrhoea irritable bowel syndrome: the role of the intestinal barrier function and integrity

(2021) Laura Prospero et al.   BMC GASTROENTEROLOGY

Tryptophan and indole metabolism in immune regulation

(2021) Alessandra Fiore et al.   CURRENT OPINION IN IMMUNOLOGY

Gut microbiota mediates intermittent-fasting alleviation of diabetes-induced cognitive impairment

(2020) Zhigang Liu et al.   Nature Communications

Lipotoxicity and Diabetic Nephropathy: Novel Mechanistic Insights and Therapeutic Opportunities

(2020) Lucas Opazo-Ríos et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gut Microbial Catabolites of Tryptophan Are Ligands and Agonists of the Aryl Hydrocarbon Receptor: A Detailed Characterization

(2020) Barbora Vyhlídalová et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gut microbiota and human NAFLD: disentangling microbial signatures from metabolic disorders

(2020) Judith Aron-Wisnewsky et al.   Nature Reviews Gastroenterology & Hepatology

Tryptophan Metabolic Pathways Are Altered in Obesity and Are Associated With Systemic Inflammation

(2020) Sofia Cussotto et al.   Frontiers in Immunology

Understanding lipotoxicity in NAFLD pathogenesis: is CD36 a key driver?

(2020) Patricia Rada et al.   Cell Death & Disease

Chitosan nanoparticles induced the antitumor effect in hepatocellular carcinoma cells by regulating ROS-mediated mitochondrial damage and endoplasmic reticulum stress

(2019) Yibing Jiang et al.   Artificial Cells Nanomedicine and Biotechnology

Skatole regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38

(2019) Koichi Kurata et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ginsenoside Rg1 Ameliorates Palmitic Acid-Induced Hepatic Steatosis and Inflammation in HepG2 Cells via the AMPK/NF-κB Pathway

(2019) Qing Xiao et al.   International Journal of Endocrinology

Lipotoxicity in Kidney, Heart, and Skeletal Muscle Dysfunction

(2019) Hiroshi Nishi et al.   Nutrients

Mono-methylindoles induce CYP1A genes and inhibit CYP1A1 enzyme activity in human hepatocytes and HepaRG cells

(2019) Barbora Vyhlídalová et al.   TOXICOLOGY LETTERS

Liver function and dysfunction - a unique window into the physiological reach of ER stress and the unfolded protein response

(2018) D. Thomas Rutkowski   FEBS Journal

Methylindoles and Methoxyindoles are Agonists and Antagonists of Human Aryl Hydrocarbon Receptor

(2018) Martina Stepankova et al.   MOLECULAR PHARMACOLOGY

Mechanisms of NAFLD development and therapeutic strategies

(2018) Scott L. Friedman et al.   NATURE MEDICINE

Fatty Acid-Induced Lipotoxicity in Pancreatic Beta-Cells During Development of Type 2 Diabetes

(2018) Yoon S. Oh et al.   Frontiers in Endocrinology

Palmitate-induced lipotoxicity is crucial for the pathogenesis of nonalcoholic fatty liver disease in cooperation with gut-derived endotoxin

(2018) Yuji Ogawa et al.   Scientific Reports

Advanced Liver Fibrosis Is Independently Associated with Palmitic Acid and Insulin Levels in Patients with Non-Alcoholic Fatty Liver Disease

(2018) Kátia Cansanção et al.   Nutrients

The microbial metabolite indole-3-propionic acid improves glucose metabolism in rats, but does not affect behaviour

(2017) Anders Abildgaard et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Palmitic Acid: Physiological Role, Metabolism and Nutritional Implications

(2017) Gianfranca Carta et al.   Frontiers in Physiology

Toyocamycin attenuates free fatty acid-induced hepatic steatosis and apoptosis in cultured hepatocytes and ameliorates nonalcoholic fatty liver disease in mice

(2017) Ikuko Takahara et al.   PLoS One

AMPKα1 overexpression alleviates the hepatocyte model of nonalcoholic fatty liver disease via inactivating p38MAPK pathway

(2016) Hong-Ai Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Molecular mechanisms of lipotoxicity and glucotoxicity in nonalcoholic fatty liver disease

(2016) Manoela Mota et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Skatole (3-Methylindole) Is a Partial Aryl Hydrocarbon Receptor Agonist and Induces CYP1A1/2 and CYP1B1 Expression in Primary Human Hepatocytes

(2016) Martin Krøyer Rasmussen et al.   PLoS One

Liver Toxicity of Cadmium Telluride Quantum Dots (CdTe QDs) Due to Oxidative Stress in Vitro and in Vivo

(2015) Ting Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Palmitic acid induced lipotoxicity is associated with altered lipid metabolism, enhanced CYP450 2E1 and intracellular calcium mediated ER stress in human hepatoma cells

(2015) Ashraf U. Nissar et al.   Toxicology Research

Palmitic acid induces autophagy in hepatocytes via JNK2 activation

(2014) Qian-qian Tu et al.   ACTA PHARMACOLOGICA SINICA

Inhibition of CYP4A Reduces Hepatic Endoplasmic Reticulum Stress and Features of Diabetes in Mice

(2014) Edmond Changkyun Park et al.   GASTROENTEROLOGY

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Oleuropein reduces free fatty acid-induced lipogenesis via lowered extracellular signal-regulated kinase activation in hepatocytes

(2012) Wonhee Hur et al.   NUTRITION RESEARCH

Nutritional Influences on Skatole Formation and Skatole Metabolism in the Pig

(2012) Raffael Wesoly et al.   Animals

Mechanisms of Lipotoxicity in NAFLD and Clinical Implications

(2011) Samar H Ibrahim et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Lipid accumulation impairs adiponectin-mediated induction of activin A by increasing TGFbeta in primary human hepatocytes

(2010) Josef Wanninger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Palmitoleate attenuates palmitate-induced Bim and PUMA up-regulation and hepatocyte lipoapoptosis

(2010) Yuko Akazawa et al.   JOURNAL OF HEPATOLOGY

Fatty liver and lipotoxicity

(2009) Michael Trauner et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Differential effect of oleic and palmitic acid on lipid accumulation and apoptosis in cultured hepatocytes

(2009) Matteo Ricchi et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

3-Methylindole is Mutagenic and a Possible Pulmonary Carcinogen

(2009) Jessica M. Weems et al.   TOXICOLOGICAL SCIENCES

Molecular Mechanisms of Lipotoxicity in Nonalcoholic Fatty Liver Disease

(2008) Harmeet Malhi et al.   SEMINARS IN LIVER DISEASE

Cytochrome P450 and Chemical Toxicology

(2007) F. Peter Guengerich   CHEMICAL RESEARCH IN TOXICOLOGY