Gut Microbial Catabolites of Tryptophan Are Ligands and Agonists of the Aryl Hydrocarbon Receptor: A Detailed Characterization

Targeting the pregnane X receptor using microbial metabolite mimicry

(2020) Zdeněk Dvořák et al.   EMBO Molecular Medicine

Mono-methylindoles induce CYP1A genes and inhibit CYP1A1 enzyme activity in human hepatocytes and HepaRG cells

(2019) Barbora Vyhlídalová et al.   TOXICOLOGY LETTERS

Regulation of the Immune Response by the Aryl Hydrocarbon Receptor

(2018) Cristina Gutiérrez-Vázquez et al.   IMMUNITY

Methylindoles and Methoxyindoles are Agonists and Antagonists of Human Aryl Hydrocarbon Receptor

(2018) Martina Stepankova et al.   MOLECULAR PHARMACOLOGY

Impact of the Gut Microbiota on Intestinal Immunity Mediated by Tryptophan Metabolism

(2018) Jing Gao et al.   Frontiers in Cellular and Infection Microbiology

The Environmental Sensor AHR Protects from Inflammatory Damage by Maintaining Intestinal Stem Cell Homeostasis and Barrier Integrity

(2018) Amina Metidji et al.   IMMUNITY

Microbial tryptophan catabolites in health and disease

(2018) Henrik M. Roager et al.   Nature Communications

A tryptophan metabolite of the skin microbiota attenuates inflammation in patients with atopic dermatitis through the aryl hydrocarbon receptor

(2018) Jinlei Yu et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Cell-Surface and Nuclear Receptors in the Colon as Targets for Bacterial Metabolites and Its Relevance to Colon Health

(2017) et al.   Nutrients

Regulation of hepatic energy metabolism by the nuclear receptor PXR

(2016) Jukka Hakkola et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Pleiotropic effects of gold(I) mixed-ligand complexes of 9-deazahypoxanthine on transcriptional activity of receptors for steroid hormones, nuclear receptors and xenoreceptors in human hepatocytes and cell lines

(2016) Kateřina Kubešová et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor

(2016) Veit Rothhammer et al.   NATURE MEDICINE

CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands

(2016) Bruno Lamas et al.   NATURE MEDICINE

Pregnane X Receptor Regulates Pathogen-Induced Inflammation and Host Defense against an Intracellular Bacterial Infection through Toll-like Receptor 4

(2016) Zhijuan Qiu et al.   Scientific Reports

Skatole (3-Methylindole) Is a Partial Aryl Hydrocarbon Receptor Agonist and Induces CYP1A1/2 and CYP1B1 Expression in Primary Human Hepatocytes

(2016) Martin Krøyer Rasmussen et al.   PLoS One

Naturally Occurring Marine Brominated Indoles Are Aryl Hydrocarbon Receptor Ligands/Agonists

(2015) Danica E. DeGroot et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles

(2015) Troy D. Hubbard et al.   Scientific Reports

Symbiotic Bacterial Metabolites Regulate Gastrointestinal Barrier Function via the Xenobiotic Sensor PXR and Toll-like Receptor 4

(2014) Madhukumar Venkatesh et al.   IMMUNITY

Tryptophan Catabolites from Microbiota Engage Aryl Hydrocarbon Receptor and Balance Mucosal Reactivity via Interleukin-22

(2013) Teresa Zelante et al.   IMMUNITY

Endogenous and Exogenous Ligands of Aryl Hydrocarbon Receptor: Current State of Art

(2011) Lucie Stejskalova et al.   CURRENT DRUG METABOLISM

Novel Stably Transfected Gene Reporter Human Hepatoma Cell Line for Assessment of Aryl Hydrocarbon Receptor Transcriptional Activity: Construction and Characterization

(2011) Aneta Novotna et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

An introduction to the molecular basics of aryl hydrocarbon receptor biology

(2010) Josef Abel et al.   BIOLOGICAL CHEMISTRY

The Uremic Toxin 3-Indoxyl Sulfate Is a Potent Endogenous Agonist for the Human Aryl Hydrocarbon Receptor

(2009) Jennifer C. Schroeder et al.   BIOCHEMISTRY

Structural Identification of Diindole Agonists of the Aryl Hydrocarbon Receptor Derived from Degradation of Indole-3-pyruvic Acid

(2009) Goutam Chowdhury et al.   CHEMICAL RESEARCH IN TOXICOLOGY