Amination of a Green Solvent via Immobilized Biocatalysis for the Synthesis of Nemtabrutinib

Efficient Synthesis of (S)-1-Boc-3-aminopiperidine in a Continuous Flow System Using ω-Transaminase-Immobilized Amino-Ethylenediamine-Modified Epoxide Supports

(2022) Xiangxiang Wang et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Utilizing biocatalysis and a sulfolane-mediated reductive acetal opening to access nemtabrutinib from cyrene

(2022) Nadine Kuhl et al.   GREEN CHEMISTRY

Engineering an Amine Transaminase for the Efficient Production of a Chiral Sacubitril Precursor

(2021) Scott J. Novick et al.   ACS Catalysis

Enantio-Complementary Continuous-Flow Synthesis of 2-Aminobutane Using Covalently Immobilized Transaminases

(2021) Christian M. Heckmann et al.   ACS Sustainable Chemistry & Engineering

Development of Continuous Flow Systems to Access Secondary Amines Through Previously Incompatible Biocatalytic Cascades**

(2021) Ashley P. Mattey et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Transaminase Engineering and Process Development for a Whole-Cell Neat Organic Process to Produce (R)-α-Phenylethylamine

(2021) Baoqin Cai et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Continuous Flow Bioamination of Ketones in Organic Solvents at Controlled Water Activity using Immobilized ω‐Transaminases

(2020) Wesley Böhmer et al.   ADVANCED SYNTHESIS & CATALYSIS

Parameters necessary to define an immobilized enzyme preparation

(2019) Joseph Boudrant et al.   PROCESS BIOCHEMISTRY

Protein immobilization technology for flow biocatalysis

(2019) María Romero-Fernández et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Bio-available Solvent Cyrene: Synthesis, Derivatization, and Applications

(2018) Jason E. Camp   ChemSusChem

The BTK Inhibitor ARQ 531 Targets Ibrutinib-Resistant CLL and Richter Transformation

(2018) Sean D. Reiff et al.   Cancer Discovery

Self-Sufficient Flow-Biocatalysis by Coimmobilization of Pyridoxal 5′-Phosphate and ω-Transaminases onto Porous Carriers

(2018) Ana I. Benítez-Mateos et al.   ACS Sustainable Chemistry & Engineering

Biocatalysis Using Immobilized Enzymes in Continuous Flow for the Synthesis of Fine Chemicals

(2018) Matthew P. Thompson et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Transaminase biocatalysis: optimization and application

(2017) Fei Guo et al.   GREEN CHEMISTRY

Practical Asymmetric Synthesis of a Calcitonin Gene-Related Peptide (CGRP) Receptor Antagonist Ubrogepant

(2017) Nobuyoshi Yasuda et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Discovery, Engineering, and Synthetic Application of Transaminase Biocatalysts

(2017) Iustina Slabu et al.   ACS Catalysis

A new target region for changing the substrate specificity of amine transaminases

(2015) Li-Jun Guan et al.   Scientific Reports

Continuous Flow Synthesis of Chiral Amines in Organic Solvents: Immobilization of E. coli Cells Containing Both ω-Transaminase and PLP

(2014) Leandro H. Andrade et al.   ORGANIC LETTERS

Enzyme immobilisation in biocatalysis: why, what and how

(2013) Roger A. Sheldon et al.   CHEMICAL SOCIETY REVIEWS

Strategies for Stabilization of Enzymes in Organic Solvents

(2013) Veronika Stepankova et al.   ACS Catalysis

Immobilization of two (R)-Amine Transaminases on an Optimized Chitosan Support for the Enzymatic Synthesis of Optically Pure Amines

(2012) Hendrik Mallin et al.   ChemCatChem

Development of an Immobilized Transaminase Capable of Operating in Organic Solvent

(2012) Matthew D. Truppo et al.   ChemCatChem

Activity and stability of different immobilized preparations of recombinant E. coli cells containing ω-transaminase

(2012) Gustav Rehn et al.   PROCESS BIOCHEMISTRY

Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture

(2010) C. K. Savile et al.   SCIENCE

Immobilization of ω-transaminases by encapsulation in a sol–gel/celite matrix

(2009) Dominik Koszelewski et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC