Utilizing biocatalysis and a sulfolane-mediated reductive acetal opening to access nemtabrutinib from cyrene

Levoglucosenone: Bio-Based Platform for Drug Discovery

(2022) Jason E. Camp et al.   Frontiers in Chemistry

Tropylium-Promoted Hydroboration Reactions: Mechanistic Insights Via Experimental and Computational Studies

(2021) Nhan N. H. Ton et al.   JOURNAL OF ORGANIC CHEMISTRY

Recent Progress in Transition-Metal-Catalyzed Asymmetric Reductive Amination

(2021) Noor U Din Reshi et al.   ACS Catalysis

Reactivity, Selectivity and Synthesis of 4‐C‐Silylated Glycosyl Donors and 4‐Deoxy Analogues

(2020) Martin Jæger Pedersen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Transition-Metal-Catalyzed Reductive Amination Employing Hydrogen

(2020) Torsten Irrgang et al.   CHEMICAL REVIEWS

Jiangrine-like scaffolds from biorenewable platforms

(2020) Rory Devlin et al.   TETRAHEDRON LETTERS

The importance of synthetic chemistry in the pharmaceutical industry

(2019) Kevin R. Campos et al.   SCIENCE

Bio-available Solvent Cyrene: Synthesis, Derivatization, and Applications

(2018) Jason E. Camp   ChemSusChem

The BTK Inhibitor ARQ 531 Targets Ibrutinib-Resistant CLL and Richter Transformation

(2018) Sean D. Reiff et al.   Cancer Discovery

Transaminase biocatalysis: optimization and application

(2017) Fei Guo et al.   GREEN CHEMISTRY

Practical Asymmetric Synthesis of a Calcitonin Gene-Related Peptide (CGRP) Receptor Antagonist Ubrogepant

(2017) Nobuyoshi Yasuda et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Process Safety Considerations for the Use of 1 M Borane Tetrahydrofuran Complex Under General Purpose Plant Conditions

(2017) Alexandre M. Monteiro et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

General Principles and Strategies for Salting-Out Informed by the Hofmeister Series

(2017) Alan M. Hyde et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Discovery, Engineering, and Synthetic Application of Transaminase Biocatalysts

(2017) Iustina Slabu et al.   ACS Catalysis

Updating and further expanding GSK's solvent sustainability guide

(2016) Catherine M. Alder et al.   GREEN CHEMISTRY

CHEM21 selection guide of classical- and less classical-solvents

(2016) Denis Prat et al.   GREEN CHEMISTRY

Thermal Overman Rearrangement of a Glucal Derivative in a Tube Reactor on Pilot Plant Scale

(2016) Franz Amann et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Opening of the 1,6-anhydro bridge with selective reduction of the acetal moiety in levoglucosenone and its derivatives

(2015) A. R. Tagirov et al.   RUSSIAN JOURNAL OF ORGANIC CHEMISTRY

A Highly Efficient Asymmetric Synthesis of Vernakalant

(2014) John Limanto et al.   ORGANIC LETTERS

Design, Synthesis, and Characterization of Novel Tetrahydropyran-Based Bacterial Topoisomerase Inhibitors with Potent Anti-Gram-Positive Activity

(2013) Jean-Philippe Surivet et al.   JOURNAL OF MEDICINAL CHEMISTRY

Expanding the Boundaries: Developing a Streamlined Tool for Eco-Footprinting of Pharmaceuticals

(2013) Concepción Jiménez-González et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Recent Applications of Levoglucosenone as Chiral Synthon

(2012) Ariel M. Sarotti et al.   CURRENT ORGANIC SYNTHESIS

Sulfolane: A Versatile Dipolar Aprotic Solvent

(2012) Ulf Tilstam   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Complexity-Based Metric for Process Mass Intensity in the Pharmaceutical Industry

(2012) Douglas P. Kjell et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture

(2010) C. K. Savile et al.   SCIENCE