标题
The physiology of bilirubin: health and disease equilibrium
作者
关键词
-
出版物
TRENDS IN MOLECULAR MEDICINE
Volume 29, Issue 4, Pages 315-328
出版商
Elsevier BV
发表日期
2023-02-22
DOI
10.1016/j.molmed.2023.01.007
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Bilirubin Levels Are Negatively Correlated with Adiposity in Obese Men and Women, and Its Catabolized Product, Urobilin, Is Positively Associated with Insulin Resistance
- (2023) Zachary A. Kipp et al. Antioxidants
- Reactive Oxygen Species (ROS) and Antioxidants as Immunomodulators in Exercise: Implications for Heme Oxygenase and Bilirubin
- (2022) David Travis Thomas et al. Antioxidants
- Bilirubin as an indicator of cardiometabolic health: a cross-sectional analysis in the UK Biobank
- (2022) Nazlisadat Seyed Khoei et al. Cardiovascular Diabetology
- Serum Bilirubin Level Is Increased in Metabolically Healthy Obesity
- (2022) Jing Fu et al. Frontiers in Endocrinology
- Serum Bilirubin Concentrations and the Prevalence of Gilbert Syndrome in Elite Athletes
- (2022) Jana Woronyczová et al. Sports Medicine-Open
- Transkingdom interactions between Lactobacilli and hepatic mitochondria attenuate western diet-induced diabetes
- (2021) Richard R. Rodrigues et al. Nature Communications
- Targeting Autophagy to Counteract Obesity-Associated Oxidative Stress
- (2021) Federico Pietrocola et al. Antioxidants
- Life-Long Hyperbilirubinemia Exposure and Bilirubin Priming Prevent In Vitro Metabolic Damage
- (2021) Annalisa Bianco et al. Frontiers in Pharmacology
- Association Between Total Bilirubin Levels and Cardio-metabolic Risk Factors Related to Obesity
- (2021) Mervat M El-Eshmawy et al. Endocrine Metabolic & Immune Disorders-Drug Targets
- Gender and gut microbiota composition determine hepatic bile acid, metabolic and inflammatory response to a single fast-food meal in healthy adults
- (2021) A. Figge et al. CLINICAL NUTRITION
- Identification of Binding Regions of Bilirubin in the Ligand-Binding Pocket of the Peroxisome Proliferator-Activated Receptor-A (PPARalpha)
- (2021) Darren M. Gordon et al. MOLECULES
- Bilirubin: The yellow hormone?
- (2021) Libor Vítek et al. JOURNAL OF HEPATOLOGY
- Effect of Silymarin Treatment on Circulating Bilirubin and Cardiovascular Disease Risk Factors in Healthy Men: A Single‐Blind, Randomized Crossover Trial
- (2021) Josif Vidimce et al. Clinical Pharmacology in Drug Development
- Higher Serum Bilirubin Levels in Response to Higher Carbohydrate Intake During Early Pregnancy and Lower Gestational Diabetes Mellitus Occurrence in Overweight and Obese Gravidae
- (2021) Wennan He et al. Frontiers in Nutrition
- Association between HO‑1 gene promoter polymorphisms and diseases (Review)
- (2021) Lin-Lin Ma et al. Molecular Medicine Reports
- Bilirubin Nanoparticles Protect Against Cardiac Ischemia/Reperfusion Injury in Mice
- (2021) Wen Ai et al. Journal of the American Heart Association
- Calorie restriction for enhanced longevity: The role of novel dietary strategies in the present obesogenic environment
- (2020) James L. Dorling et al. AGEING RESEARCH REVIEWS
- Bilirubin as a signaling molecule
- (2020) Libor Vítek MEDICINAL RESEARCH REVIEWS
- Biliverdin Reductase A (BVRA) Knockout in Adipocytes Induces Hypertrophy and Reduces Mitochondria in White Fat of Obese Mice
- (2020) David E. Stec et al. Biomolecules
- Bilirubin remodels murine white adipose tissue by reshaping mitochondrial activity and the coregulator profile of peroxisome proliferator-activated receptor α
- (2020) Darren M Gordon et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Systemic Review of Biodegradable Nanomaterials in Nanomedicine
- (2020) Shi Su et al. Nanomaterials
- Bilirubin, Intestinal Integrity, the Microbiome, and Inflammation
- (2020) Libor Vítek et al. NEW ENGLAND JOURNAL OF MEDICINE
- Serum Bilirubin in the Czech Population ― Relationship to the Risk of Myocardial Infarction in Males ―
- (2020) Lenka Eremiasova et al. CIRCULATION JOURNAL
- Association Between Atazanavir‐Induced Hyperbilirubinemia and Cardiovascular Disease in Patients Infected with HIV
- (2020) Michael Li et al. Journal of the American Heart Association
- Rats Genetically Selected for High Aerobic Exercise Capacity Have Elevated Plasma Bilirubin by Upregulation of Hepatic Biliverdin Reductase-A (BVRA) and Suppression of UGT1A1
- (2020) Terry D. Hinds et al. Antioxidants
- Bilirubin as a metabolic hormone: the physiological relevance of low levels
- (2020) Justin F. Creeden et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Natural Product Heme Oxygenase Inducers as Treatment for Nonalcoholic Fatty Liver Disease
- (2020) David E. Stec et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Therapeutic application and construction of bilirubin incorporated nanoparticles
- (2020) Qing Yao et al. JOURNAL OF CONTROLLED RELEASE
- Bilirubin Nanoparticles Reduce Diet-Induced Hepatic Steatosis, Improve Fat Utilization, and Increase Plasma β-Hydroxybutyrate
- (2020) Terry D. Hinds et al. Frontiers in Pharmacology
- Identification of a bilirubin receptor that may mediate a component of cholestatic itch
- (2019) James Meixiong et al. eLife
- RNA-sequencing in human HepG2 hepatocytes reveals PPARα mediates transcriptome responsiveness of bilirubin.
- (2019) Darren M Gordon et al. PHYSIOLOGICAL GENOMICS
- Bilirubin as a predictor of diseases of civilization. Is it time to establish decision limits for serum bilirubin concentrations?
- (2019) Libor Vítek ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- Bilirubin Safeguards Cardiorenal and Metabolic Diseases: a Protective Role in Health
- (2019) Terry D. Hinds et al. CURRENT HYPERTENSION REPORTS
- Bilirubin reduces visceral obesity and insulin resistance by suppression of inflammatory cytokines
- (2019) Ryoko Takei et al. PLoS One
- Impact of obese levels on the hepatic expression of nuclear receptors and drug-metabolizing enzymes in adult and offspring mice
- (2019) Pei Wang et al. Acta Pharmaceutica Sinica B
- Biliverdin reductase and bilirubin in hepatic disease
- (2018) Lauren Weaver et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Bilirubin acts as a multi-potent guardian of cardiovascular integrity: more than just a radical idea
- (2018) Andrew Cameron Bulmer et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Mild hyperbilirubinaemia as an endogenous mitigator of overweight and obesity: Implications for improved metabolic health
- (2018) Nazlisadat Seyed Khoei et al. ATHEROSCLEROSIS
- Diagnostic criteria and contributors to Gilbert’s syndrome
- (2018) Karl-Heinz Wagner et al. CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES
- Bilirubin in the Liver–Gut Signaling Axis
- (2018) Abdul-Rizaq Hamoud et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Bilirubin, a new therapeutic for kidney transplant?
- (2018) Vikram L. Sundararaghavan et al. Transplantation Reviews
- Bilirubin, a Cardiometabolic Signaling Molecule
- (2018) Terry D. Hinds et al. HYPERTENSION
- Induction of mild hyperbilirubinemia: Hype or real therapeutic opportunity?
- (2018) Libor Vitek et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Untangling the relationship between diet and visceral fat mass through blood metabolomics and gut microbiome profiling
- (2017) T Pallister et al. INTERNATIONAL JOURNAL OF OBESITY
- Serum Bilirubin Levels and Promoter Variations in HMOX1 and UGT1A1 Genes in Patients with Fabry Disease
- (2017) Alena Jirásková et al. Oxidative Medicine and Cellular Longevity
- Atazanavir use and carotid intima media thickness progression in HIV
- (2016) Dominic Chow et al. AIDS
- Multistimuli-Responsive Bilirubin Nanoparticles for Anticancer Therapy
- (2016) Yonghyun Lee et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Bilirubin Nanoparticles as a Nanomedicine for Anti-inflammation Therapy
- (2016) Yonghyun Lee et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Biliverdin Reductase A Attenuates Hepatic Steatosis by Inhibition of Glycogen Synthase Kinase (GSK) 3β Phosphorylation of Serine 73 of Peroxisome Proliferator-activated Receptor (PPAR) α
- (2016) Terry D. Hinds et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Does bilirubin prevent hepatic steatosis through activation of the PPARα nuclear receptor?
- (2016) Terry D. Hinds et al. MEDICAL HYPOTHESES
- Glucuronidation and UGT isozymes in bladder: new targets for the treatment of uroepithelial carcinomas?
- (2016) Vikram L. Sundararaghavan et al. Oncotarget
- Longer telomeres in chronic, moderate, unconjugated hyperbilirubinaemia: insights from a human study on Gilbert’s Syndrome
- (2016) Anela Tosevska et al. Scientific Reports
- Lysozyme and bilirubin bind to ACE and regulate its conformation and shedding
- (2016) Sergei M. Danilov et al. Scientific Reports
- Bilirubin Binding to PPARα Inhibits Lipid Accumulation
- (2016) David E. Stec et al. PLoS One
- Features of an altered AMPK metabolic pathway in Gilbert’s Syndrome, and its role in metabolic health
- (2016) Christine Mölzer et al. Scientific Reports
- A prospective, randomized clinical trial of antiretroviral therapies on carotid wall thickness
- (2015) James H. Stein et al. AIDS
- Looking to the horizon: the role of bilirubin in the development and prevention of age-related chronic diseases
- (2015) Karl-Heinz Wagner et al. CLINICAL SCIENCE
- Effects of Adipocyte Aryl Hydrocarbon Receptor Deficiency on PCB-Induced Disruption of Glucose Homeostasis in Lean and Obese Mice
- (2015) Nicki A. Baker et al. ENVIRONMENTAL HEALTH PERSPECTIVES
- Longitudinal Blood Pressure Control, Long-Term Mortality, and Predictive Utility of Serum Liver Enzymes and Bilirubin in Hypertensive PatientsNovelty and Significance
- (2015) Linsay McCallum et al. HYPERTENSION
- Protective effect of heme oxygenase induction in ethinylestradiol-induced cholestasis
- (2015) Lucie Muchova et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Atorvastatin treatment increases plasma bilirubin but not HMOX1 expression in stable angina patients
- (2015) Bosa Mirjanic-Azaric et al. SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION
- Biliverdin reductase isozymes in metabolism
- (2015) Luke O’Brien et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Bilirubin Increases Insulin Sensitivity by Regulating Cholesterol Metabolism, Adipokines and PPARγ Levels
- (2015) Jinfeng Liu et al. Scientific Reports
- Endogenously elevated bilirubin modulates kidney function and protects from circulating oxidative stress in a rat model of adenine-induced kidney failure
- (2015) Ai-Ching Boon et al. Scientific Reports
- Hyperbilirubinemia modulates myocardial function, aortic ejection, and ischemic stress resistance in the Gunn rat
- (2014) Bhavisha Bakrania et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Association Between Flavonoid-Rich Fruit and Vegetable Consumption and Total Serum Bilirubin
- (2014) Paul D. Loprinzi et al. ANGIOLOGY
- Unconjugated Bilirubin Mediates Heme Oxygenase-1–Induced Vascular Benefits in Diabetic Mice
- (2014) Jian Liu et al. DIABETES
- The Relationship Between Serum Bilirubin and Crohn’s Disease
- (2014) Martin Leníček et al. INFLAMMATORY BOWEL DISEASES
- Body Fat Percentage Is a Major Determinant of Total Bilirubin Independently of UGT1A1*28 Polymorphism in Young Obese
- (2014) Luís Belo et al. PLoS One
- Antihypertensive Actions of Moderate Hyperbilirubinemia: Role of Superoxide Inhibition
- (2013) D. E. Stec et al. AMERICAN JOURNAL OF HYPERTENSION
- A Bilirubin-Inducible Fluorescent Protein from Eel Muscle
- (2013) Akiko Kumagai et al. CELL
- Protection from age-related increase in lipid biomarkers and inflammation contributes to cardiovascular protection in Gilbert's syndrome
- (2013) Marlies Wallner et al. CLINICAL SCIENCE
- The molecular basis for the immunomodulatory activities of unconjugated bilirubin
- (2013) Sushrut Jangi et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Gilbert's syndrome and the risk of death: a population-based cohort study
- (2013) Laura J. Horsfall et al. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
- Serum bilirubin levels are lower in overweight asymptomatic middle-aged adults: An early indicator of metabolic syndrome?
- (2013) Zala Jenko-Pražnikar et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Ketone bodies as signaling metabolites
- (2013) John C. Newman et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Effects of statin treatments and polymorphisms in UGT1A1 and SLCO1B1 on serum bilirubin levels in Chinese patients with hypercholesterolaemia
- (2012) Miao Hu et al. ATHEROSCLEROSIS
- Can we live longer by eating less? A review of caloric restriction and longevity
- (2012) Lauren W. Roth et al. MATURITAS
- Association of serum bilirubin and promoter variations in HMOX1 and UGT1A1 genes with sporadic colorectal cancer
- (2011) Alena Jirásková et al. INTERNATIONAL JOURNAL OF CANCER
- Serum bilirubin levels in familial hypercholesterolemia: a new risk marker for cardiovascular disease?
- (2011) Pernette R.W. de Sauvage Nolting et al. JOURNAL OF LIPID RESEARCH
- Effect of Different Doses of Aerobic Exercise Training on Total Bilirubin Levels
- (2011) DAMON L. SWIFT et al. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
- Moderate hyperbilirubinemia improves renal hemodynamics in ANG II-dependent hypertension
- (2010) Trinity Vera et al. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
- Peroxisome Proliferator-activated Receptor Alpha (PPARα) Agonists Induce Constitutive Androstane Receptor (CAR) and Cytochrome P450 2B in Rat Primary Hepatocytes
- (2010) Kosuke Saito et al. Drug Metabolism and Pharmacokinetics
- Drug delivery and nanoparticles: Applications and hazards
- (2010) de Jong International Journal of Nanomedicine
- Effects of Herbal Supplements on Drug Glucuronidation. Review of Clinical, Animal, andIn VitroStudies
- (2010) Mohamed-Eslam Mohamed et al. PLANTA MEDICA
- Serum bilirubin levels and UGT1A1 promoter variations in patients with schizophrenia
- (2010) Libor Vítek et al. PSYCHIATRY RESEARCH
- Association of systemic lupus erythematosus with low serum bilirubin levels
- (2010) L Vítek et al. SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
- Inhibitory effects of commonly used herbal extracts on UGT1A1 enzyme activity
- (2010) Mohamed-Eslam F. Mohamed et al. XENOBIOTICA
- Inhibition of bilirubin metabolism induces moderate hyperbilirubinemia and attenuates ANG II-dependent hypertension in mice
- (2009) Trinity Vera et al. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
- Bilirubin Chemistry and Metabolism; Harmful and Protective Aspects
- (2009) Libor Vitek et al. CURRENT PHARMACEUTICAL DESIGN
- Effects of Japanese Herbal Medicine, Kampo, on Human UGT1A1 Activity
- (2009) Miki Katoh et al. Drug Metabolism and Pharmacokinetics
- Acute effect of weight loss on levels of total bilirubin in obese, cardiovascular high-risk patients: an analysis from the lead-in period of the Sibutramine Cardiovascular Outcome trial
- (2009) Charlotte Andersson et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Bilirubin and glutathione have complementary antioxidant and cytoprotective roles
- (2009) T. W. Sedlak et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Improved resistance to serum oxidation in Gilbert's syndrome: A mechanism for cardiovascular protection
- (2008) Andrew C. Bulmer et al. ATHEROSCLEROSIS
- Hepatic Nuclear Factor 1 Inhibitor Ursodeoxycholic Acid Influences Pharmacokinetics of the Organic Anion Transporting Polypeptide 1B1 Substrate Rosuvastatin and Bilirubin
- (2008) Y.-J. He et al. DRUG METABOLISM AND DISPOSITION
- Transcriptional regulation of human UGT1A1 gene expression through distal and proximal promoter motifs: implication of defects in the UGT1A1 gene promoter
- (2008) Junko Sugatani et al. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
- Effect of troglitazone on CYP1A1 induction
- (2008) Hyung Gyun Kim et al. TOXICOLOGY
- Serum Total Bilirubin Level and Prevalent Lower-Extremity Peripheral Arterial Disease
- (2007) Todd S. Perlstein et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started