The role of circulating cell-free DNA as an inflammatory mediator after stroke

Cell-Free DNA in Ischemic Stroke

(2022) Sarina R. Falcione et al.   STROKE

Endogenous Deoxyribonuclease Activity and Cell-Free Deoxyribonucleic Acid in Acute Ischemic Stroke: A Cohort Study

(2022) Gerrit M. Grosse et al.   STROKE

TLR9 regulates NLRP3 inflammasome activation via the NF-kB signaling pathway in diabetic nephropathy

(2022) Jinfeng Shen et al.   Diabetology & Metabolic Syndrome

Systems spatiotemporal dynamics of traumatic brain injury at single-cell resolution reveals humanin as a therapeutic target

(2022) Douglas Arneson et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Systemic inflammation after stroke: implications for post‐stroke comorbidities

(2022) Alba Simats et al.   EMBO Molecular Medicine

AIMing 2 treat atherosclerosis

(2022) Oliver Soehnlein et al.   Nature Reviews Cardiology

Circulating cell-free DNA in health and disease — the relationship to health behaviours, ageing phenotypes and metabolomics

(2022) Laura Kananen et al.   GeroScience

Post-injury immunosuppression and secondary infections are caused by an AIM2 inflammasome-driven signaling cascade

(2021) Stefan Roth et al.   IMMUNITY

Small Molecule Approaches to Treat Autoimmune and Inflammatory Diseases (Part II): Nucleic Acid Sensing Antagonists and Inhibitors

(2021) Xiaoqing Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The inhibitory receptor TIM-3 limits activation of the cGAS-STING pathway in intra-tumoral dendritic cells by suppressing extracellular DNA uptake

(2021) Álvaro de Mingo Pulido et al.   IMMUNITY

The changing landscape of atherosclerosis

(2021) Peter Libby   NATURE

STING Attenuates ROS Induced intervertebral disc degeneration

(2021) Qiang Guo et al.   OSTEOARTHRITIS AND CARTILAGE

Serial profiling of cell-free DNA and nucleosome histone modifications in cell cultures

(2021) Vida Ungerer et al.   Scientific Reports

Sputum cell‐free DNA: Valued surrogate sample for the detection of EGFR exon 20 p.T790M mutation in patients with advanced lung adenocarcinoma and acquired resistance to EGFR‐TKIs

(2021) Zheng Wang et al.   Cancer Medicine

AIM2 deletion enhances blood‐brain barrier integrity in experimental ischemic stroke

(2021) Si‐yi Xu et al.   CNS Neuroscience & Therapeutics

Extracellular HMGB1 augments macrophage inflammation by facilitating the endosomal accumulation of ALD-DNA via TLR2/4-mediated endocytosis

(2021) Jincheng Lu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Interleukin-1β suppression dampens inflammatory leukocyte production and uptake in atherosclerosis

(2021) Jan Hettwer et al.   CARDIOVASCULAR RESEARCH

Engineering CXCL12 Biomimetic Decoy‐Integrated Versatile Immunosuppressive Nanoparticle for Ischemic Stroke Therapy with Management of Overactivated Brain Immune Microenvironment

(2021) Jinjin Shi et al.   Small Methods

AIM2 inflammasome contributes to brain injury and chronic post-stroke cognitive impairment in mice

(2020) Hyunha Kim et al.   BRAIN BEHAVIOR AND IMMUNITY

Inhibition of double‐strand DNA‐sensing cGAS ameliorates brain injury after ischemic stroke

(2020) Qian Li et al.   EMBO Molecular Medicine

Immune responses to stroke: mechanisms, modulation, and therapeutic potential

(2020) Costantino Iadecola et al.   JOURNAL OF CLINICAL INVESTIGATION

cGAS/STING Pathway Activation Contributes to Delayed Neurodegeneration in Neonatal Hypoxia-Ischemia Rat Model: Possible Involvement of LINE-1

(2020) Marcin Gamdzyk et al.   MOLECULAR NEUROBIOLOGY

Targeting Inflammation Driven by HMGB1

(2020) Huan Yang et al.   Frontiers in Immunology

Gonadal Hormones E2 and P Mitigate Cerebral Ischemia-Induced Upregulation of the AIM2 and NLRC4 Inflammasomes in Rats

(2020) Pardes Habib et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Deoxyribonucleases and Their Applications in Biomedicine

(2020) Lucia Lauková et al.   Biomolecules

Role of DAMPs and of Leukocytes Infiltration in Ischemic Stroke: Insights from Animal Models and Translation to the Human Disease

(2020) Rosita Stanzione et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Detection of cytokine-induced sickness behavior after ischemic stroke by an optimized behavioral assessment battery

(2020) Stefan Roth et al.   BRAIN BEHAVIOR AND IMMUNITY

TLR9 is essential for HMGB1-mediated post-myocardial infarction tissue repair through affecting apoptosis, cardiac healing, and angiogenesis

(2019) Fang-Yuan Liu et al.   Cell Death & Disease

Pharmacological Modulation of Neutrophil Extracellular Traps Reverses Thrombotic Stroke tPA (Tissue-Type Plasminogen Activator) Resistance

(2019) Carolina Peña-Martínez et al.   STROKE

The HDAC3 inhibitor RGFP966 ameliorated ischemic brain damage by downregulating the AIM2 inflammasome

(2019) Mei‐Juan Zhang et al.   FASEB JOURNAL

Immune Sensing of Cell Death through Recognition of Histone Sequences by C-Type Lectin-Receptor-2d Causes Inflammation and Tissue Injury

(2019) Jiann-Jyh Lai et al.   IMMUNITY

Targeting of cell-free DNA by DNase I diminishes endothelial dysfunction and inflammation in a rat model of cardiopulmonary bypass

(2019) Carolyn Weber et al.   Scientific Reports

Cpg-ODN, a TLR9 Agonist, Aggravates Myocardial Ischemia/Reperfusion Injury by Activation of TLR9-P38 MAPK Signaling

(2018) Liang Xie et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Double-Strand DNA Sensing Aim2 Inflammasome Regulates Atherosclerotic Plaque Vulnerability

(2018) Nicole Paulin et al.   CIRCULATION

Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity

(2018) Dave Boucher et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Brain-released alarmins and stress response synergize in accelerating atherosclerosis progression after stroke

(2018) Stefan Roth et al.   Science Translational Medicine

Thrombus Neutrophil Extracellular Traps Content Impair tPA-Induced Thrombolysis in Acute Ischemic Stroke

(2018) Celina Ducroux et al.   STROKE

SCIL-STROKE (Subcutaneous Interleukin-1 Receptor Antagonist in Ischemic Stroke)

(2018) Craig J. Smith et al.   STROKE

Genetic Polymorphisms of the Mitochondrial Aldehyde Dehydrogenase ALDH2 Gene in a Large Ethnic Hakka Population in Southern China

(2018) Zhixiong Zhong et al.   MEDICAL SCIENCE MONITOR

High levels of circulating cell-free DNA are a biomarker of active SLE

(2018) Yalan Xu et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Characteristics, properties, and potential applications of circulating cell-free dna in clinical diagnostics: a focus on transplantation

(2018) Karen Sherwood et al.   JOURNAL OF IMMUNOLOGICAL METHODS

New mitochondrial DNA synthesis enables NLRP3 inflammasome activation

(2018) Zhenyu Zhong et al.   NATURE

Damage-Associated Molecular Patterns in Inflammatory Diseases

(2018) Jong Seong Roh et al.   Immune Network

Comprehensive human cell-type methylation atlas reveals origins of circulating cell-free DNA in health and disease

(2018) Joshua Moss et al.   Nature Communications

Overview of the IL-1 family in innate inflammation and acquired immunity

(2017) Charles A. Dinarello   IMMUNOLOGICAL REVIEWS

NEMO–IKKβ Are Essential for IRF3 and NF-κB Activation in the cGAS–STING Pathway

(2017) Run Fang et al.   JOURNAL OF IMMUNOLOGY

Selectivity of Human TLR9 for Double CpG Motifs and Implications for the Recognition of Genomic DNA

(2017) Jelka Pohar et al.   JOURNAL OF IMMUNOLOGY

LINE-1 Hypermethylation in Serum Cell-Free DNA of Relapsing Remitting Multiple Sclerosis Patients

(2017) Marina Dunaeva et al.   MOLECULAR NEUROBIOLOGY

In Retrospect: The inflammasome turns 15

(2017) Mohamed Lamkanfi et al.   NATURE

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Direct detection of early-stage cancers using circulating tumor DNA

(2017) Jillian Phallen et al.   Science Translational Medicine

Neutrophil extracellular traps are increased in patients with acute ischemic stroke: prognostic significance

(2017) Juana Vallés et al.   THROMBOSIS AND HAEMOSTASIS

Prenatal Diagnosis Innovation: Genome Sequencing of Maternal Plasma

(2016) Felix C.K. Wong et al.   Annual Review of Medicine

Cell-free DNA Comprises an In Vivo Nucleosome Footprint that Informs Its Tissues-Of-Origin

(2016) Matthew W. Snyder et al.   CELL

The HMGB1 C-Terminal Tail Regulates DNA Bending

(2016) Rebecca H. Blair et al.   JOURNAL OF MOLECULAR BIOLOGY

Inflammation and Stroke: An Overview

(2016) Josef Anrather et al.   Neurotherapeutics

Identification of tissue-specific cell death using methylation patterns of circulating DNA

(2016) Roni Lehmann-Werman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interleukin-1 in Stroke

(2016) Oluwaseun A. Sobowale et al.   STROKE

Extracellular histones, cell-free DNA, or nucleosomes: differences in immunostimulation

(2016) Gerben Marsman et al.   Cell Death & Disease

Neutrophil extracellular traps in ischemia-reperfusion injury-induced myocardial no-reflow: therapeutic potential of DNase-based reperfusion strategy

(2015) Lan Ge et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Cell-Free DNA: An Upcoming Biomarker in Transplantation

(2015) E. M. Gielis et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Combined first trimester or cffDNA screening

(2015) J Hyett   BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY

DAMP Signaling is a Key Pathway Inducing Immune Modulation after Brain Injury

(2015) A. Liesz et al.   JOURNAL OF NEUROSCIENCE

Prophylactic antibiotics after acute stroke for reducing pneumonia in patients with dysphagia (STROKE-INF): a prospective, cluster-randomised, open-label, masked endpoint, controlled clinical trial

(2015) Lalit Kalra et al.   LANCET

AIM2 and NLRC4 inflammasomes contribute with ASC to acute brain injury independently of NLRP3

(2015) Adam Denes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The complex role of DNA, histones and HMGB1 in the pathogenesis of SLE

(2014) David S. Pisetsky   AUTOIMMUNITY

Cytosolic-DNA-Mediated, STING-Dependent Proinflammatory Gene Induction Necessitates Canonical NF- B Activation through TBK1

(2014) T. Abe et al.   JOURNAL OF VIROLOGY

The systemic immune response to trauma: an overview of pathophysiology and treatment

(2014) Janet M Lord et al.   LANCET

The TLR9 Ligand, CpG‐ODN, Induces Protection against Cerebral Ischemia/Reperfusion Injury via Activation of PI3K/Akt Signaling

(2014) Chen Lu et al.   Journal of the American Heart Association

Ischemic stroke biomarkers in blood

(2013) Lena Rothstein et al.   Biomarkers in Medicine

Monitoring tumor-derived cell-free DNA in patients with solid tumors: Clinical perspectives and research opportunities

(2013) Angela Esposito et al.   CANCER TREATMENT REVIEWS

Synthetic Oligodeoxynucleotides Containing Suppressive TTAGGG Motifs Inhibit AIM2 Inflammasome Activation

(2013) J. J. Kaminski et al.   JOURNAL OF IMMUNOLOGY

Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING

(2013) Xu Zhang et al.   MOLECULAR CELL

Gestational age and maternal weight effects on fetal cell-free DNA in maternal plasma

(2013) Eric Wang et al.   PRENATAL DIAGNOSIS

Extracellular Chromatin Is an Important Mediator of Ischemic Stroke in Mice

(2012) Simon F. De Meyer et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

CpG-ODN, the TLR9 agonist, attenuates myocardial ischemia/reperfusion injury: Involving activation of PI3K/Akt signaling

(2012) Zhijuan Cao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Pleural fluid cell-free DNA integrity index to identify cytologically negative malignant pleural effusions including mesotheliomas

(2012) Krishna B Sriram et al.   BMC CANCER

Towards the identification of blood biomarkers for acute stroke in humans: a comprehensive systematic review

(2012) Nazeeha Hasan et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor

(2012) Tengchuan Jin et al.   IMMUNITY

The immunology of acute stroke

(2012) Ángel Chamorro et al.   Nature Reviews Neurology

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

Severe Stroke Induces Long-Lasting Alterations of High-Mobility Group Box 1

(2012) Juliane Schulze et al.   STROKE

Plasmacytoid Dendritic Cells in Atherosclerosis

(2012) Yvonne Döring et al.   Frontiers in Physiology

DNA binding to proteolytically activated TLR9 is sequence-independent and enhanced by DNA curvature

(2011) Yue Li et al.   EMBO JOURNAL

Underuse of Antithrombotic Therapy Caused High Incidence of Ischemic Stroke in Patients with Atrial Fibrillation

(2011) Hsiu-Chin Yu et al.   International Journal of Stroke

Neutrophil extracellular traps promote deep vein thrombosis in mice

(2011) A. BRILL et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Suppressing Immunosuppression after Stroke

(2011) Christian Meisel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Risk and Cumulative Risk of Stroke Recurrence

(2011) Keerthi M. Mohan et al.   STROKE

Contribution of bacterial and viral infections to attributable mortality in patients with severe burns: An autopsy series

(2010) Laurie C. D’Avignon et al.   BURNS

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

The value of serial plasma nuclear and mitochondrial DNA levels in patients with acute ischemic stroke

(2010) Nai-Wen Tsai et al.   CLINICA CHIMICA ACTA

Haemodialysis as a model for studying endogenous plasma DNA: oligonucleosome-like structure and clearance

(2010) P. RUMORE et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

IL-1 pathways in inflammation and human diseases

(2010) Cem Gabay et al.   Nature Reviews Rheumatology

Extracellular DNA traps promote thrombosis

(2010) T. A. Fuchs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systematic Review and Stratified Meta-analysis of the Efficacy of Interleukin-1 Receptor Antagonist in Animal Models of Stroke

(2009) Victoria Banwell et al.   Journal of Stroke & Cerebrovascular Diseases

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

(2009) Teresa Fernandes-Alnemri et al.   NATURE

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

(2009) Veit Hornung et al.   NATURE

An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome

(2009) Tilmann Bürckstümmer et al.   NATURE IMMUNOLOGY