One-Pot Synthesis of 1-Aryl-3-trifluoromethylpyrazoles Using Nitrile Imines and Mercaptoacetaldehyde As a Surrogate of Acetylene

Quadruple Functionalized Pyrazole Pharmacophores via One‐pot Regioselective [3 + 2] Cycloaddition of Fluorinated Nitrile Imines and Dicyanoalkenes

(2022) Yin Zhou et al.   Chemistry-An Asian Journal

Trifluoromethylated Pyrazoles via Sequential (3 + 2)-Cycloaddition of Fluorinated Nitrile Imines with Chalcones and Solvent-Dependent Deacylative Oxidation Reactions

(2022) Anna Kowalczyk et al.   ORGANIC LETTERS

Dual Incorporation of Trifluoromethyl and Cyano Groups into Pyrazole Pharmcophores via Silver-Catalyzed Cycloaddition Reaction of Trifluorodiazoethane

(2022) Cheng-Feng Gao et al.   CCS Chemistry

Regioselective Synthesis of 3‐Trifluoromethyl 4‐Subtituted Pyrazoles by [3+2] Cycloaddition of Trifluoroacetonitrile Imines and Nitroalkenes

(2022) Ke‐Hu Wang et al.   Asian Journal of Organic Chemistry

Fluorinated and Non-Fluorinated 1,4-Diarylpyrazoles via MnO2-Mediated Mechanochemical Deacylative Oxidation of 5-Acylpyrazolines

(2022) Greta Utecht-Jarzyńska et al.   MOLECULES

Fluorinated Pyrazoles: From Synthesis to Applications

(2021) Pavel K. Mykhailiuk   CHEMICAL REVIEWS

α,β-Disubstituted CF3-Enones as a Trifluoromethyl Building Block: Regioselective Preparation of Totally Substituted 3-CF3-Pyrazoles

(2021) Vasiliy M. Muzalevskiy et al.   JOURNAL OF ORGANIC CHEMISTRY

Regioselective Decarboxylative Cycloaddition Route to Fully Substituted 3‐CF 3 ‐Pyrazoles from Nitrilimines and Isoxazolidinediones

(2021) Yu‐Chen Tian et al.   ADVANCED SYNTHESIS & CATALYSIS

Copper-Catalyzed Reductive Ring-Cleavage of Isoxazoles: Synthesis of Fluoroalkylated Enaminones and Application for the Preparation of Celecoxib, Deracoxib, and Mavacoxib

(2021) Chao Wan et al.   JOURNAL OF ORGANIC CHEMISTRY

A straightforward conversion of 1,4-quinones into polycyclic pyrazoles via [3 + 2]-cycloaddition with fluorinated nitrile imines

(2021) Greta Utecht-Jarzyńska et al.   Beilstein Journal of Organic Chemistry

Synthesis, Characterization, and Biological Study of 3‐Trifluoromethylpyrazole Tethered Chalcone‐Pyrrole and Pyrazoline‐Pyrrole Derivatives

(2021) Nishant Kisan Rasal et al.   CHEMISTRY & BIODIVERSITY

Berotralstat (BCX7353): Structure-Guided Design of a Potent, Selective, and Oral Plasma Kallikrein Inhibitor to Prevent Attacks of Hereditary Angioedema (HAE)

(2021) Pravin L Kotian et al.   JOURNAL OF MEDICINAL CHEMISTRY

Alkyne Surrogates in Cycloaddition Reactions for the Preparation of Molecules of Interest

(2021) Muriel Amatore et al.   Asian Journal of Organic Chemistry

Trifluorodiazoethane: A versatile building block to access trifluoromethylated heterocycles

(2021) Anuj Kumar et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Discovery of Pyrido[2,3-b]indole Derivatives with Gram-negative Activity Targeting Both DNA Gyrase and Topoisomerase IV

(2020) Yimin Hu et al.   JOURNAL OF MEDICINAL CHEMISTRY

2,2,2-Trifluorodiazoethane (CF3CHN2): A Long Journey since 1943

(2020) Pavel K. Mykhailiuk   CHEMICAL REVIEWS

A straightforward access to 3-trifluoromethyl-1H-indazoles via (3+2)-cycloaddition of arynes with nitrile imines derived from trifluoroacetonitrile

(2020) Anna Kowalczyk et al.   JOURNAL OF FLUORINE CHEMISTRY

Trapping of trifluoroacetonitrile imines with mercaptoacetaldehyde and mercaptocarboxylic acids: An access to fluorinated 1,3,4-thiadiazine derivatives via (3+3)-annulation

(2019) Greta Utecht-Jarzyńska et al.   JOURNAL OF FLUORINE CHEMISTRY

1,4-Dithiane-2,5-diol: An Attractive Platform for the Synthesis of Sulfur-Containing Functionalized Heterocycles

(2018) Francesco Zamberlan et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

[3 + 2]-Cycloaddition of in Situ Generated Nitrile Imines and Acetylene for Assembling of 1,3-Disubstituted Pyrazoles with Quantitative Deuterium Labeling

(2018) Vladimir V. Voronin et al.   JOURNAL OF ORGANIC CHEMISTRY

Polysubstituted 3-trifluoromethylpyrazoles: regioselective (3 + 2)-cycloaddition of trifluoroacetonitrile imines with enol ethers and functional group transformations

(2018) Greta Utecht et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthetic Applications and Biological Properties of 1,4-Dithiane-2,5-diol and its Aducts: A Review

(2018) Isadora Silva Luna et al.   CURRENT ORGANIC SYNTHESIS

First (3+2)-Cycloadditions of Thiochalcones as C=S Dipolarophiles: Efficient Synthesis of 1,3,4-Thiadiazoles via Reactions with Fluorinated Nitrile Imines

(2017) Grzegorz Mlostoń et al.   SYNTHESIS-STUTTGART

Fluoroalkyl-Substituted Diazomethanes and Their Application in a General Synthesis of Pyrazoles and Pyrazolines

(2016) Lucas Mertens et al.   CHEMISTRY-A EUROPEAN JOURNAL

Trifluoromethylated 2,3-dihydro-1,3,4-thiadiazoles via the regioselective [3+2]-cycloadditions of fluorinated nitrile imines with aryl, hetaryl, and ferrocenyl thioketones

(2016) Grzegorz Mlostoń et al.   JOURNAL OF FLUORINE CHEMISTRY

Copper-catalyzed C–N cross-coupling of arylboronic acids with N-acylpyrazoles

(2016) Jin Zhang et al.   TETRAHEDRON LETTERS

Solvent- and Transition Metal Catalyst-Dependent Regioselectivity in the [3+2] Cyclocondensation of Trifluoromethyl-α,β-ynones with Hydrazines: Switchable Access to 3- and 5-Trifluoromethylpyrazoles

(2015) Min-Tsang Hsieh et al.   ADVANCED SYNTHESIS & CATALYSIS

Trifluoromethylpyrazoles as anti-inflammatory and antibacterial agents: A review

(2015) Kamalneet Kaur et al.   JOURNAL OF FLUORINE CHEMISTRY

The Eschenmoser sulfide contraction method and its application in the synthesis of natural products

(2015) Syed Raziullah Hussaini et al.   TETRAHEDRON

Copper-Catalyzed Arylation of Nitrogen Heterocycles from Anilines under Ligand-Free Conditions

(2014) Dounia Toummini et al.   CHEMISTRY-A EUROPEAN JOURNAL

Rapid and Efficient Trifluoromethylation of Aromatic and Heteroaromatic Compounds Using Potassium Trifluoroacetate Enabled by a Flow System

(2013) Mao Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rational Design of Strongly Blue-Emitting Cuprous Complexes with Thermally Activated Delayed Fluorescence and Application in Solution-Processed OLEDs

(2013) Xu-Lin Chen et al.   CHEMISTRY OF MATERIALS

New strategy for the regioselective synthesis of 1-phenyl-3-trifluoromethyl-1H-pyrazoles

(2013) Nilo Zanatta et al.   TETRAHEDRON LETTERS

Discovery of a novel azaindole class of antibacterial agents targeting the ATPase domains of DNA gyrase and Topoisomerase IV

(2012) John I. Manchester et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of diversely fluorinated pyrazoles as novel active agrochemical ingredients

(2012) Florence Giornal et al.   JOURNAL OF FLUORINE CHEMISTRY

A novel three-step synthesis of Celecoxib via palladium-catalyzed direct arylation

(2011) Steven M. Gaulier et al.   TETRAHEDRON LETTERS