Article
Gastroenterology & Hepatology
Maria Juarez-Fernandez, Naroa Goikoetxea-Usandizaga, David Porras, Maria Victoria Garcia-Mediavilla, Miren Bravo, Marina Serrano-Macia, Jorge Simon, Teresa C. Delgado, Sofia Lachiondo-Ortega, Susana Martinez-Florez, Oscar Lorenzo, Mercedes Rincon, Marta Varela-Rey, Leticia Abecia, Hector Rodriguez, Juan Anguita, Esther Nistal, Maria Luz Martinez-Chantar, Sonia Sanchez-Campos
Summary: This study provides evidence for the relevance of the interaction between mitochondria and microbiota in NASH and identifies targeting this interaction as a valuable therapeutic approach.
Article
Clinical Neurology
Hongshuai Liu, Chuangchuang Zhang, Jiadi Xu, Jing Jin, Liam Cheng, Xinyuan Miao, Qian Wu, Zhiliang Wei, Peiying Liu, Hanzhang Lu, Peter C. M. van Zijl, Christopher A. Ross, Jun Hua, Wenzhen Duan
Summary: Huntington's disease is a fatal neurodegenerative disorder caused by a mutation in the HTT gene, and research using a mouse model has shown that changes in CBVa can be detected in the premanifest stage of the disease, with non-allele-specific HTT silencing showing promising therapeutic effects.
Article
Oncology
Syed Hassan Mehdi, Austin C. Gentry, Jue-Yeon Lee, Chong-Pyoung Chung, Donghoon Yoon
Summary: Multiple myeloma (MM) is a clonal B-cell disorder characterized by the proliferation of malignant plasma cells in the bone marrow, and interactions between MM cells and the bone microenvironment play a significant role. NIPEP-OSS, a peptide with targeted osteogenic activity, delays the progression of mouse myeloma through bone formation in animal models of MM bone disease. In both NSG and C57BL/KaLwRij models, the survival rates and median survival times were significantly different between the control and treated groups, indicating the potential anti-myeloma activity of NIPEP-OSS.
Article
Medicine, General & Internal
Nicholas C. Turner, Mafalda Oliveira, Sacha J. Howell, Florence Dalenc, Javier Cortes, Henry L. Gomez Moreno, Xichun Hu, Komal Jhaveri, Petr Krivorotko, Sibylle Loibl, Serafin Morales Murillo, Meena Okera, Yeon Hee Park, Joohyuk Sohn, Masakazu Toi, Eriko Tokunaga, Samih Yousef, Lyudmila Zhukova, Elza C. de Bruin, Lynda Grinsted, Gaia Schiavon, Andrew Foxley, Hope S. Rugo
Summary: Capivasertib-fulvestrant therapy significantly improves progression-free survival in patients with hormone receptor-positive advanced breast cancer, particularly those with AKT pathway alterations.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Urology & Nephrology
Xiaofang Wang, Li Jiang, Ka Thao, Caroline R. Sussman, Timothy LaBranche, Michael Palmer, Peter C. Harris, G. Stanley McKnight, Klaus P. Hoeflich, Stefanie Schalm, Vicente E. Torres
Summary: Upregulation of cAMP-dependent and cAMP-independent PKA signaling promotes cystogenesis in polycystic kidney disease (PKD). Activation of PKA-I promotes cystogenesis, while its inhibition prevents cyst formation. Inhibition of PKA activity can directly and/or indirectly inhibit multiple pro-proliferative pathways and is protective in vivo.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Medicine, Research & Experimental
Jing Pan, Min Shi, Fan Guo, Liang Ma, Ping Fu
Summary: The study demonstrated that the use of STAT3 inhibitor can delay the progression of hyperuricemia-induced CKD renal fibrosis, improve renal function, and lower serum uric acid levels. Additionally, the inhibitor can suppress multiple fibrotic signaling pathways and cytokine expressions.
Article
Biochemistry & Molecular Biology
Panshuang Qiao, Yi Sun, Yiming Wang, Simei Lin, Yongpan An, Liang Wang, Jihan Liu, Yajun Huang, Baoxue Yang, Hong Zhou
Summary: Hyperuricemia-induced oxidative stress contributes to hyperuricemic nephropathy, and the molecular mechanisms underlying the disturbed redox homeostasis in kidneys are unclear. This study showed that NRF2, a key regulator, plays a role in improving mitochondrial homeostasis and fibrosis in renal tubular cells by reducing oxidative stress, upregulating the antioxidant signaling pathway, and downregulating the TGF-beta 1 signaling pathway. The activation of NRF2 represents a promising strategy to restore redox homeostasis and combat hyperuricemic nephropathy.
Article
Medicine, Research & Experimental
Xi Huang, Liwen Gao, Ruyu Deng, Yu Peng, Shanshan Wu, Jiandong Lu, Xinhui Liu
Summary: Huangqi-Danshen decoction (HDD), a Chinese herbal preparation, was found to protect against adenine-induced CKD, improve renal pathological injury and fibrosis, and reshape glucose metabolism profiles in CKD mice. HDD treatment restored the expression of key enzymes of glucose metabolism in the kidneys of CKD mice. This study suggests the potential of targeting glucose metabolism for the treatment of CKD.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Neurosciences
Kirill Chaprov, Alexander Rezvykh, Sergei Funikov, Tamara A. Ivanova, Ekaterina A. Lysikova, Alexei Deykin, Michail S. Kukharsky, Alexey Yu Aksinenko, Sergey O. Bachurin, Natalia Ninkina, Vladimir L. Buchman
Summary: The research findings indicate that DF402 can delay the progression of ALS in mouse models and impact their gait, suggesting that DF402 may serve as a potential therapy for complex ALS treatment combinations.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Oncology
Angeliki Andrikopoulou, Spyridoula Chatzinikolaou, Evangelia Panourgias, Maria Kaparelou, Michalis Liontos, Meletios-Athanasios Dimopoulos, Flora Zagouri
Summary: Over 50% of breast tumors have genetic alterations in the PI3K pathway, with PIK3CA mutations being the most common. Capivasertib, a novel AKT inhibitor, has shown efficacy in breast cancer cell lines and in combination with paclitaxel and fulvestrant. Ongoing Phase III trials will provide further insights into the therapeutic role of capivasertib in breast cancer.
Article
Endocrinology & Metabolism
Yan Fan, Long-Teng Yan, Zheng Yao, Guang-Yi Xiong
Summary: The study showed that BCA treatment effectively improved NAFLD in rats by reducing liver index and improving pathological changes, while also regulating lipid metabolism indexes and gene expressions related to lipid metabolism.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Xiawei Dang, Lihong Zhang, Antonietta Franco, Gerald W. Dorn II
Summary: The involvement of mitochondria in neurodegenerative diseases is widespread. Recent development of bioactive molecules that modulate mitochondrial dynamics offers a new therapeutic approach. Activation of mitochondrial fusion and motility can improve mitochondrial pathology and symptoms in SOD1 mutant amyotrophic lateral sclerosis (ALS) patients and mice.
HUMAN MOLECULAR GENETICS
(2023)
Article
Virology
Zhao-Yang Wang, Zi-Da Zhen, Dong-Ying Fan, Pei-Gang Wang, Jing An
Summary: This study found that Axl deficient mice showed accelerated progression and exacerbated brain damage during Japanese encephalitis infection, possibly due to the anti-inflammatory and neuroprotective role of Axl. Axl deficiency did not affect the infection and target cell tropism of Japanese encephalitis virus.
Article
Reproductive Biology
Zhongyu Wang, Yake Huang, Ling Long, Li Zhou, Yan Huang, Lei Gan, Aimin Pu, Sufen Li, Rongkai Xie
Summary: Biochemical recurrence in ovarian cancer, characterized by rising CA-125 levels without radiographic evidence of disease, poses a challenge in treatment strategies. Apatinib, either alone or in combination with chemotherapy, has shown efficacy in delaying clinical progression in recurrent ovarian cancer patients, particularly those with biochemical-only relapse. This study highlights the promising prospect of using apatinib to treat ovarian cancer patients with asymptomatic biochemical recurrence.
JOURNAL OF OVARIAN RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Xiangyu Li, Mingfang Li, Yongfeng Shao, Weidong Gu, Buqing Ni, Jiaxi Gu, Minglong Chen
Summary: The study aimed to determine whether mini-invasive transthoracic atrial fibrillation ablation can delay the progression of atrial fibrillation from paroxysmal to persistent. The results showed that patients who chose transthoracic atrial fibrillation ablation had a lower incidence of progression to persistent atrial fibrillation compared to patients who chose conservative therapy.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)