Protein Kinase A Downregulation Delays the Development and Progression of Polycystic Kidney Disease

The genetic background significantly impacts the severity of kidney cystic disease in the Pkd1RC/RC mouse model of autosomal dominant polycystic kidney disease.

(2021) Jennifer Arroyo et al.   KIDNEY INTERNATIONAL

KARATE: PKA-induced KRAS4B-RHOA-mTORC2 supercomplex phosphorylates AKT in insulin signaling and glucose homeostasis

(2021) Hiroshi Senoo et al.   MOLECULAR CELL

Phosphoproteomic Identification of Vasopressin/cAMP/PKA-Dependent Signaling in Kidney

(2020) Karim Salhadar et al.   MOLECULAR PHARMACOLOGY

Phase Separation of a PKA Regulatory Subunit Controls cAMP Compartmentation and Oncogenic Signaling

(2020) Jason Z. Zhang et al.   CELL

Automated total kidney volume measurements in pre-clinical magnetic resonance imaging for resourcing imaging data, annotations, and source code

(2020) Marie E. Edwards et al.   KIDNEY INTERNATIONAL

Everything you ever wanted to know about PKA regulation and its involvement in mammalian sperm capacitation

(2020) Carolina Baro Graf et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Protein Kinase A as a Promising Target for Heart Failure Drug Development

(2019) Nancy S. Saad et al.   ARCHIVES OF MEDICAL RESEARCH

Lineage-specific roles of hedgehog-GLI signaling during mammalian kidney development

(2019) Robert D’Cruz et al.   PEDIATRIC NEPHROLOGY

Autosomal dominant polycystic kidney disease

(2019) Emilie Cornec-Le Gall et al.   LANCET

Regulation of AKT phosphorylation by GSK3β and PTEN to control chemoresistance in breast cancer

(2019) Chunyi Gao et al.   BREAST CANCER RESEARCH AND TREATMENT

Direct physical interaction of active Ras with mSIN1 regulates mTORC2 signaling

(2019) Mehraj-U-Din Lone et al.   BMC CANCER

The PI3K/Akt/mTOR pathway in polycystic kidney disease: A complex interaction with polycystins and primary cilium

(2019) Jean Piero Margaria et al.   CELLULAR SIGNALLING

Expanding the phenotypic spectrum of variants in PDE4D/PRKAR1A: from acrodysostosis to acroscyphodysplasia

(2018) Caroline Michot et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Conformational Landscape of the PRKACA-DNAJB1 Chimeric Kinase, the Driver for Fibrolamellar Hepatocellular Carcinoma

(2018) Michael D. Tomasini et al.   Scientific Reports

A Practical Guide for Treatment of Rapidly Progressive ADPKD with Tolvaptan

(2018) Fouad T. Chebib et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Clinical and translational pharmacological aspects of the management of fibrous dysplasia of bone

(2018) Marlous Rotman et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Polycystic kidney disease

(2018) Carsten Bergmann et al.   Nature Reviews Disease Primers

Mutations causing acrodysostosis-2 facilitate activation of phosphodiesterase 4D3

(2017) Claire Briet et al.   HUMAN MOLECULAR GENETICS

TRAF3 delays cyst formation induced by NF-κB signaling

(2017) Liping Sun et al.   IUBMB LIFE

Tolvaptan in Later-Stage Autosomal Dominant Polycystic Kidney Disease

(2017) Vicente E. Torres et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mechanisms for restraining cAMP-dependent protein kinase revealed by subunit quantitation and cross-linking approaches

(2017) Ryan Walker-Gray et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Isoform-specific subcellular localization and function of protein kinase A identified by mosaic imaging of mouse brain

(2017) Ronit Ilouz et al.   eLife

Risk of Renal Cell Carcinoma Among Kidney Transplant Recipients in the United States

(2016) S. Karami et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Hedgehog signaling pathway: a novel model and molecular mechanisms of signal transduction

(2016) Tatiana Gorojankina   CELLULAR AND MOLECULAR LIFE SCIENCES

Hedgehog signalling

(2016) Raymond Teck Ho Lee et al.   DEVELOPMENT

cAMP-dependent protein kinase A (PKA) regulates angiogenesis by modulating tip cell behavior in a Notch-independent manner

(2016) Pavel I. Nedvetsky et al.   DEVELOPMENT

Carney complex: A familial lentiginosis predisposing to a variety of tumors

(2016) Constantine A. Stratakis   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Urogenital development in Pallister–Hall syndrome is disrupted in a cell-lineage-specific manner by constitutive expression of GLI3 repressor

(2015) Joshua Blake et al.   HUMAN MOLECULAR GENETICS

Glycogen synthase kinase-3β promotes cyst expansion in polycystic kidney disease

(2015) Shixin Tao et al.   KIDNEY INTERNATIONAL

Autosomal-dominant polycystic kidney disease (ADPKD): executive summary from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference

(2015) Arlene B. Chapman et al.   KIDNEY INTERNATIONAL

Autosomal dominant polycystic kidney disease: the changing face of clinical management

(2015) Albert C M Ong et al.   LANCET

A historical overview of protein kinases and their targeted small molecule inhibitors

(2015) Robert Roskoski   PHARMACOLOGICAL RESEARCH

A dynamic interface between ubiquitylation and cAMP signaling

(2015) Laura Rinaldi et al.   Frontiers in Pharmacology

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring

(2015) Maria V. Irazabal et al.   Jove-Journal of Visualized Experiments

New insights into genotype–phenotype correlation for GLI3 mutations

(2014) Florence Démurger et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Selective Expression of a Dominant-Negative Type I  PKA Regulatory Subunit in Striatal Medium Spiny Neurons Impairs Gene Expression and Leads to Reduced Feeding and Locomotor Activity

(2014) L. Yang et al.   JOURNAL OF NEUROSCIENCE

Polycystic Kidney Disease and Cancer after Renal Transplantation

(2014) J. B. Wetmore et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

PKA signaling drives mammary tumorigenesis through Src

(2014) A G Beristain et al.   ONCOGENE

IKK interacts with rictor and regulates mTORC2

(2013) Yuanfei Xu et al.   CELLULAR SIGNALLING

Different mutations inPDE4Dassociated with developmental disorders with mirror phenotypes

(2013) Anna Lindstrand et al.   JOURNAL OF MEDICAL GENETICS

A Pkd1-Fbn1 Genetic Interaction Implicates TGF-  Signaling in the Pathogenesis of Vascular Complications in Autosomal Dominant Polycystic Kidney Disease

(2013) D. Liu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Proteolysis of MOB1 by the ubiquitin ligase praja2 attenuates Hippo signalling and supports glioblastoma growth

(2013) Luca Lignitto et al.   Nature Communications

Thyroid-specific ablation of the Carney complex gene, PRKAR1A, results in hyperthyroidism and follicular thyroid cancer

(2012) Daphne R Pringle et al.   ENDOCRINE-RELATED CANCER

Protein Kinase A Alterations in Endocrine Tumors

(2012) B. Yu et al.   HORMONE AND METABOLIC RESEARCH

Functional polycystin-1 dosage governs autosomal dominant polycystic kidney disease severity

(2012) Katharina Hopp et al.   JOURNAL OF CLINICAL INVESTIGATION

Kidney Injury Accelerates Cystogenesis via Pathways Modulated by Heme Oxygenase and Complement

(2012) J. Zhou et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Tolvaptan in Patients with Autosomal Dominant Polycystic Kidney Disease

(2012) Vicente E. Torres et al.   NEW ENGLAND JOURNAL OF MEDICINE

Protein kinase A type I activates a CRE-element more efficiently than protein kinase A type II regardless of C subunit isoform

(2011) Øystein Stakkestad et al.   BMC BIOCHEMISTRY

Comprehensive analysis of kinase inhibitor selectivity

(2011) Mindy I Davis et al.   NATURE BIOTECHNOLOGY

Control of PKA stability and signalling by the RING ligase praja2

(2011) Luca Lignitto et al.   NATURE CELL BIOLOGY

RecurrentPRKAR1AMutation in Acrodysostosis with Hormone Resistance

(2011) Agnès Linglart et al.   NEW ENGLAND JOURNAL OF MEDICINE

8-Chloro-Cyclic AMP and Protein Kinase A I-Selective Cyclic AMP Analogs Inhibit Cancer Cell Growth through Different Mechanisms

(2011) Simona Lucchi et al.   PLoS One

Cell-Type Specific Expression of a Dominant Negative PKA Mutation in Mice

(2011) Brandon S. Willis et al.   PLoS One

Genome-Wide RNAi Screen Reveals Disease-Associated Genes That Are Common to Hedgehog and Wnt Signaling

(2011) L. S. Jacob et al.   Science Signaling

Mouse Prkar1a haploinsufficiency leads to an increase in tumors in the Trp53+/− or Rb1+/− backgrounds and chemically induced skin papillomas by dysregulation of the cell cycle and Wnt signaling

(2010) Madson Q. Almeida et al.   HUMAN MOLECULAR GENETICS

Mouse models of altered protein kinase A signaling

(2009) Lawrence S Kirschner et al.   ENDOCRINE-RELATED CANCER

Cyclic nucleotide signaling in polycystic kidney disease

(2009) Xiaofang Wang et al.   KIDNEY INTERNATIONAL

c-Src Regulates Akt Signaling in Response to Ghrelin via β-Arrestin Signaling-Independent and -Dependent Mechanisms

(2009) Maria Lodeiro et al.   PLoS One

GLI3 Repressor Controls Nephron Number via Regulation of Wnt11 and Ret in Ureteric Tip Cells

(2009) Jason E. Cain et al.   PLoS One

Regulation of transforming growth factor β-induced responses by protein kinase A in pancreatic acinar cells

(2008) Huibin Yang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Protein Kinase A Type I and Type II Define Distinct Intracellular Signaling Compartments

(2008) Giulietta Di Benedetto et al.   CIRCULATION RESEARCH

The cAMP effectors Epac and protein kinase a (PKA) are involved in the hepatic cystogenesis of an animal model of autosomal recessive polycystic kidney disease (ARPKD)

(2008) Jesús M. Banales et al.   HEPATOLOGY

Pharmacological PKA Inhibition: All May Not Be What It Seems

(2008) A. J. Murray   Science Signaling

Protein Kinase A-Independent Inhibition of Proliferation and Induction of Apoptosis in Human Thyroid Cancer Cells by 8-Cl-Adenosine

(2007) Audrey J. Robinson-White et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Vasopressin Directly Regulates Cyst Growth in Polycystic Kidney Disease

(2007) X. Wang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY