Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy

Genetic regulation of serum IgA levels and susceptibility to common immune, infectious, kidney, and cardio-metabolic traits

(2022) Lili Liu et al.   Nature Communications

Lymphocytes sense antibodies through human FCRL proteins: Emerging roles in mucosal immunity

(2021) Mate Tolnay   JOURNAL OF LEUKOCYTE BIOLOGY

Medical Records-Based Genetic Studies of the Complement System

(2021) Atlas Khan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes

(2021) Catherine C. Robertson et al.   NATURE GENETICS

Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression

(2021) Urmo Võsa et al.   NATURE GENETICS

An open approach to systematically prioritize causal variants and genes at all published human GWAS trait-associated loci

(2021) Edward Mountjoy et al.   NATURE GENETICS

Human Fc Receptor-like 3 Inhibits Regulatory T Cell Function and Binds Secretory IgA

(2020) Stuti Agarwal et al.   Cell Reports

Recurrence of immunoglobulin A nephropathy after kidney transplantation: a narrative review on incidence, risk factors, pathophysiology and management of immunosuppressive therapy

(2020) Barbara Infante et al.   Clinical Kidney Journal

Genome-Wide Meta-Analysis Identifies Three Novel Susceptibility Loci and Reveals Ethnic Heterogeneity of Genetic Susceptibility for IgA Nephropathy

(2020) Ming Li et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Open Targets Platform: supporting systematic drug–target identification and prioritisation

(2020) David Ochoa et al.   NUCLEIC ACIDS RESEARCH

GARFIELD classifies disease-relevant genomic features through integration of functional annotations with association signals

(2019) Valentina Iotchkova et al.   NATURE GENETICS

Polygenic Prediction of Weight and Obesity Trajectories from Birth to Adulthood

(2019) Amit V. Khera et al.   CELL

A genetics-led approach defines the drug target landscape of 30 immune-related traits

(2019) Hai Fang et al.   NATURE GENETICS

Assessment of network module identification across complex diseases

(2019) Sarvenaz Choobdar et al.   NATURE METHODS

Complement Inhibitors in Clinical Trials for Glomerular Diseases

(2019) Peter F. Zipfel et al.   Frontiers in Immunology

Activity-by-contact model of enhancer–promoter regulation from thousands of CRISPR perturbations

(2019) Charles P. Fulco et al.   NATURE GENETICS

FUN-LDA: A Latent Dirichlet Allocation Model for Predicting Tissue-Specific Functional Effects of Noncoding Variation: Methods and Applications

(2018) Daniel Backenroth et al.   AMERICAN JOURNAL OF HUMAN GENETICS

An integrative investigation of the therapeutic mechanism of Ainsliaea fragrans Champ. in cervicitis using liquid chromatography tandem mass spectrometry based on a rat plasma metabolomics strategy

(2018) Xiaoyong Zhang et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity

(2018) John B. Harley et al.   NATURE GENETICS

Genomic atlas of the human plasma proteome

(2018) Benjamin B. Sun et al.   NATURE

Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations

(2018) Amit V. Khera et al.   NATURE GENETICS

Renal compartment–specific genetic variation analyses identify new pathways in chronic kidney disease

(2018) Chengxiang Qiu et al.   NATURE MEDICINE

Co-regulatory networks of human serum proteins link genetics to disease

(2018) Valur Emilsson et al.   SCIENCE

Impact of Genetic Polymorphisms on Human Immune Cell Gene Expression

(2018) Benjamin J. Schmiedel et al.   CELL

The inflammatory function of human IgA

(2018) Ivo S. Hansen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The UK Biobank resource with deep phenotyping and genomic data

(2018) Clare Bycroft et al.   NATURE

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

(2018) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Open Targets Platform: new developments and updates two years on

(2018) Denise Carvalho-Silva et al.   NUCLEIC ACIDS RESEARCH

Stachydrine ameliorates isoproterenol-induced cardiac hypertrophy and fibrosis by suppressing inflammation and oxidative stress through inhibiting NF-κB and JAK/STAT signaling pathways in rats

(2017) Lingling Zhao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Genome-wide association and HLA region fine-mapping studies identify susceptibility loci for multiple common infections

(2017) Chao Tian et al.   Nature Communications

Connecting genetic risk to disease end points through the human blood plasma proteome

(2017) Karsten Suhre et al.   Nature Communications

GeneHancer: genome-wide integration of enhancers and target genes in GeneCards

(2017) Simon Fishilevich et al.   Database-The Journal of Biological Databases and Curation

Associations between genetic risk variants for kidney diseases and kidney disease etiology

(2017) Sebastian Wunnenburger et al.   Scientific Reports

1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function

(2017) Mathias Gorski et al.   Scientific Reports

A novel random effect model for GWAS meta-analysis and its application to trans-ethnic meta-analysis

(2016) Jingchunzi Shi et al.   BIOMETRICS

The Role of TNF Superfamily Member 13 in the Progression of IgA Nephropathy

(2016) S. S. Han et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A scored human protein–protein interaction network to catalyze genomic interpretation

(2016) Taibo Li et al.   NATURE METHODS

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

(2016) Cristian Pattaro et al.   Nature Communications

Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores

(2015) Bjarni J. Vilhjálmsson et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Epstein-Barr Virus Oncoprotein Super-enhancers Control B Cell Growth

(2015) Hufeng Zhou et al.   Cell Host & Microbe

The role of tonsillectomy in IgA nephropathy

(2015) Sandro Feriozzi et al.   JOURNAL OF NEPHROLOGY

The support of human genetic evidence for approved drug indications

(2015) Matthew R Nelson et al.   NATURE GENETICS

Partitioning heritability by functional annotation using genome-wide association summary statistics

(2015) Hilary K Finucane et al.   NATURE GENETICS

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

(2015) Brendan K Bulik-Sullivan et al.   NATURE GENETICS

Mouse genome database 2016

(2015) Carol J. Bult et al.   NUCLEIC ACIDS RESEARCH

Identification of new susceptibility loci for IgA nephropathy in Han Chinese

(2015) Ming Li et al.   Nature Communications

Biological interpretation of genome-wide association studies using predicted gene functions

(2015) Tune H. Pers et al.   Nature Communications

MAGMA: Generalized Gene-Set Analysis of GWAS Data

(2015) Christiaan A. de Leeuw et al.   PLoS Computational Biology

Second-generation PLINK: rising to the challenge of larger and richer datasets

(2015) Christopher C Chang et al.   GigaScience

Identifying Causal Variants at Loci with Multiple Signals of Association

(2014) F. Hormozdiari et al.   GENETICS

Predicting HLA alleles from high-resolution SNP data in three Southeast Asian populations

(2014) Nisha Esakimuthu Pillai et al.   HUMAN MOLECULAR GENETICS

Cytokines Alter IgA1O-Glycosylation by Dysregulating C1GalT1 and ST6GalNAc-II Enzymes

(2014) Hitoshi Suzuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The genetics and immunobiology of IgA nephropathy

(2014) Krzysztof Kiryluk et al.   JOURNAL OF CLINICAL INVESTIGATION

Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens

(2014) Krzysztof Kiryluk et al.   NATURE GENETICS

An atlas of genetic influences on human blood metabolites

(2014) So-Youn Shin et al.   NATURE GENETICS

Disease burden and risk profile in referred patients with moderate chronic kidney disease: composition of the German Chronic Kidney Disease (GCKD) cohort

(2014) S. Titze et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

The Mouse Genome Database (MGD): facilitating mouse as a model for human biology and disease

(2014) Janan T. Eppig et al.   NUCLEIC ACIDS RESEARCH

Bayesian Test for Colocalisation between Pairs of Genetic Association Studies Using Summary Statistics

(2014) Claudia Giambartolomei et al.   PLoS Genetics

A New Equation to Estimate Glomerular Filtration Rate

(2013) Andrew S. Levey et al.   ANNALS OF INTERNAL MEDICINE

SMAD regulatory networks construct a balanced immune system

(2013) Nidhi Malhotra et al.   IMMUNOLOGY

The Genotype-Tissue Expression (GTEx) project

(2013) John Lonsdale et al.   NATURE GENETICS

Imputing Amino Acid Polymorphisms in Human Leukocyte Antigens

(2013) Xiaoming Jia et al.   PLoS One

Pathogenesis of Immunoglobulin A Nephropathy: Recent Insight from Genetic Studies

(2012) Krzysztof Kiryluk et al.   Annual Review of Medicine

An integrated map of genetic variation from 1,092 human genomes

(2012)   NATURE

Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits

(2012) Jian Yang et al.   NATURE GENETICS

Detecting overlapping protein complexes in protein-protein interaction networks

(2012) Tamás Nepusz et al.   NATURE METHODS

Geographic Differences in Genetic Susceptibility to IgA Nephropathy: GWAS Replication Study and Geospatial Risk Analysis

(2012) Krzysztof Kiryluk et al.   PLoS Genetics

Human metabolic individuality in biomedical and pharmaceutical research

(2011) Karsten Suhre et al.   NATURE

A genome-wide association study in Han Chinese identifies multiple susceptibility loci for IgA nephropathy

(2011) Xue-Qing Yu et al.   NATURE GENETICS

Genome-wide association study identifies susceptibility loci for IgA nephropathy

(2011) Ali G Gharavi et al.   NATURE GENETICS

Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery

(2011) F. Zhu et al.   NUCLEIC ACIDS RESEARCH

GCTA: A Tool for Genome-wide Complex Trait Analysis

(2010) Jian Yang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

GLay: community structure analysis of biological networks

(2010) G. Su et al.   BIOINFORMATICS

PheWAS: demonstrating the feasibility of a phenome-wide scan to discover gene-disease associations

(2010) J. C. Denny et al.   BIOINFORMATICS

METAL: fast and efficient meta-analysis of genomewide association scans

(2010) C. J. Willer et al.   BIOINFORMATICS

Functions of Runx in IgA class switch recombination

(2010) Manabu Sugai et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

HLA Has Strongest Association with IgA Nephropathy in Genome-Wide Analysis

(2010) J. Feehally et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

DrugBank 3.0: a comprehensive resource for 'Omics' research on drugs

(2010) C. Knox et al.   NUCLEIC ACIDS RESEARCH

The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function

(2010) David Warde-Farley et al.   NUCLEIC ACIDS RESEARCH

New Equations to Estimate GFR in Children with CKD

(2009) G. J. Schwartz et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

ToppGene Suite for gene list enrichment analysis and candidate gene prioritization

(2009) J. Chen et al.   NUCLEIC ACIDS RESEARCH

Smad3 knockout mice exhibit impaired intestinal mucosal healing

(2008) Cheri R Owen et al.   LABORATORY INVESTIGATION

The Immunological Genome Project: networks of gene expression in immune cells

(2008) Tracy S P Heng et al.   NATURE IMMUNOLOGY