Genetic regulation of serum IgA levels and susceptibility to common immune, infectious, kidney, and cardio-metabolic traits

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome

(2021) Edward L. Huttlin et al.   CELL

Medical Records-Based Genetic Studies of the Complement System

(2021) Atlas Khan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

TRAF3 in T Cells Restrains Negative Regulators of LAT to Promote TCR/CD28 Signaling

(2021) Tina Arkee et al.   JOURNAL OF IMMUNOLOGY

Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression

(2021) Urmo Võsa et al.   NATURE GENETICS

An Update on the Current State of Management and Clinical Trials for IgA Nephropathy

(2021) Chee Kay Cheung et al.   Journal of Clinical Medicine

Serum IgA, IgM, and IgG responses in COVID-19

(2020) Huan Ma et al.   Cellular & Molecular Immunology

Distinct features of SARS-CoV-2-specific IgA response in COVID-19 patients

(2020) Hai-qiong Yu et al.   EUROPEAN RESPIRATORY JOURNAL

TRAF3 Acts as a Checkpoint of B Cell Receptor Signaling to Control Antibody Class Switch Recombination and Anergy

(2020) Zhangguo Chen et al.   JOURNAL OF IMMUNOLOGY

IgA dominates the early neutralizing antibody response to SARS-CoV-2

(2020) Delphine Sterlin et al.   Science Translational Medicine

Transforming Growth Factor-β Signaling in Immunity and Cancer

(2019) Eduard Batlle et al.   IMMUNITY

miRDB: an online database for prediction of functional microRNA targets

(2019) Yuhao Chen et al.   NUCLEIC ACIDS RESEARCH

The MR-Base platform supports systematic causal inference across the human phenome

(2018) Gibran Hemani et al.   eLife

Histone Deacetylase 7 mediates tissue-specific autoimmunity via control of innate effector function in invariant Natural Killer T Cells

(2018) Herbert G Kasler et al.   eLife

Genome-Wide Association Study on Immunoglobulin G Glycosylation Patterns

(2018) Annika Wahl et al.   Frontiers in Immunology

The UK Biobank resource with deep phenotyping and genomic data

(2018) Clare Bycroft et al.   NATURE

Mouse Genome Database (MGD) 2019

(2018) Carol J Bult et al.   NUCLEIC ACIDS RESEARCH

The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019

(2018) Annalisa Buniello et al.   NUCLEIC ACIDS RESEARCH

Overview of the IL-1 family in innate inflammation and acquired immunity

(2017) Charles A. Dinarello   IMMUNOLOGICAL REVIEWS

Identification of sequence variants influencing immunoglobulin levels

(2017) Stefan Jonsson et al.   NATURE GENETICS

GWAS for serum galactose-deficient IgA1 implicates critical genes of the O-glycosylation pathway

(2017) Krzysztof Kiryluk et al.   PLoS Genetics

Fast Principal-Component Analysis Reveals Convergent Evolution of ADH1B in Europe and East Asia

(2016) Kevin J. Galinsky et al.   AMERICAN JOURNAL OF HUMAN GENETICS

LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis

(2016) Jie Zheng et al.   BIOINFORMATICS

A novel random effect model for GWAS meta-analysis and its application to trans-ethnic meta-analysis

(2016) Jingchunzi Shi et al.   BIOMETRICS

Genetic Drivers of Epigenetic and Transcriptional Variation in Human Immune Cells

(2016) Lu Chen et al.   CELL

Novel Insights into the Multiple Sclerosis Risk GeneANKRD55

(2016) Aitzkoa Lopez de Lapuente et al.   JOURNAL OF IMMUNOLOGY

IgA1 Glycosylation Is Heritable in Healthy Twins

(2016) Hannah J. Lomax-Browne et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Reference-based phasing using the Haplotype Reference Consortium panel

(2016) Po-Ru Loh et al.   NATURE GENETICS

Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation

(2016) Thomas J Hoffmann et al.   NATURE GENETICS

Next-generation genotype imputation service and methods

(2016) Sayantan Das et al.   NATURE GENETICS

Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets

(2016) Zhihong Zhu et al.   NATURE GENETICS

A scored human protein–protein interaction network to catalyze genomic interpretation

(2016) Taibo Li et al.   NATURE METHODS

Regulation of normal B-cell differentiation and malignant B-cell survival by OCT2

(2016) Daniel J. Hodson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Detection of human adaptation during the past 2000 years

(2016) Yair Field et al.   SCIENCE

TMEM258 Is a Component of the Oligosaccharyltransferase Complex Controlling ER Stress and Intestinal Inflammation

(2016) Daniel B. Graham et al.   Cell Reports

Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores

(2015) Bjarni J. Vilhjálmsson et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A global reference for human genetic variation

(2015) Richard A. Gibbs et al.   NATURE

Genetic studies of body mass index yield new insights for obesity biology

(2015) Adam E. Locke et al.   NATURE

An atlas of genetic correlations across human diseases and traits

(2015) Brendan Bulik-Sullivan et al.   NATURE GENETICS

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

(2015) Brendan K Bulik-Sullivan et al.   NATURE GENETICS

Variants in ELL2 influencing immunoglobulin levels associate with multiple myeloma

(2015) Bhairavi Swaminathan et al.   Nature Communications

UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age

(2015) Cathie Sudlow et al.   PLOS MEDICINE

Predicting effective microRNA target sites in mammalian mRNAs

(2015) Vikram Agarwal et al.   eLife

Toward Adenotonsillectomy in Children

(2015) David G. Ingram et al.   JAMA Pediatrics

Role of tumor necrosis factor superfamily in neuroinflammation and autoimmunity

(2015) Sandip Sonar   Frontiers in Immunology

Fast and accurate imputation of summary statistics enhances evidence of functional enrichment

(2014) Bogdan Pasaniuc et al.   BIOINFORMATICS

IgA measurements in over 12 000 Swedish twins reveal sex differential heritability and regulatory locus near CD30L

(2014) Alexander Viktorin et al.   HUMAN MOLECULAR GENETICS

Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens

(2014) Krzysztof Kiryluk et al.   NATURE GENETICS

Fast Principal Component Analysis of Large-Scale Genome-Wide Data

(2014) Gad Abraham et al.   PLoS One

Bayesian Test for Colocalisation between Pairs of Genetic Association Studies Using Summary Statistics

(2014) Claudia Giambartolomei et al.   PLoS Genetics

Loci Associated with N-Glycosylation of Human Immunoglobulin G Show Pleiotropy with Autoimmune Diseases and Haematological Cancers

(2013) Gordan Lauc et al.   PLoS Genetics

Role of secretory IgA in infection and maintenance of homeostasis

(2012) Blaise Corthésy   AUTOIMMUNITY REVIEWS

CITED2 functions as a molecular switch of cytokine-induced proliferation and quiescence

(2012) Y-T Chou et al.   CELL DEATH AND DIFFERENTIATION

Genome-wide association study identifies TNFSF13 as a susceptibility gene for IgA in a South Chinese population in smokers

(2012) Chen Yang et al.   IMMUNOGENETICS

Fast and accurate genotype imputation in genome-wide association studies through pre-phasing

(2012) Bryan Howie et al.   NATURE GENETICS

Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits

(2012) Jian Yang et al.   NATURE GENETICS

Dysfunctions of the Iga system: a common link between intestinal and renal diseases

(2011) Christina Papista et al.   Cellular & Molecular Immunology

Structure and function relationships in IgA

(2011) J M Woof et al.   Mucosal Immunology

Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease

(2011) Gosia Trynka et al.   NATURE GENETICS

LITAF Mediation of Increased TNF-α Secretion from Inflamed Colonic Lamina Propria Macrophages

(2011) Kristen N. Bushell et al.   PLoS One

PheWAS: demonstrating the feasibility of a phenome-wide scan to discover gene-disease associations

(2010) J. C. Denny et al.   BIOINFORMATICS

METAL: fast and efficient meta-analysis of genomewide association scans

(2010) C. J. Willer et al.   BIOINFORMATICS

TRAF3 Controls Activation of the Canonical and Alternative NFκB by the Lymphotoxin Beta Receptor

(2010) Pradeep Bista et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TNF Receptor-Associated Factor 3 Is Required for T Cell-Mediated Immunity and TCR/CD28 Signaling

(2010) P. Xie et al.   JOURNAL OF IMMUNOLOGY

Requirement for Runx Proteins in IgA Class Switching Acting Downstream of TGF- 1 and Retinoic Acid Signaling

(2010) K. Watanabe et al.   JOURNAL OF IMMUNOLOGY

ToppCluster: a multiple gene list feature analyzer for comparative enrichment clustering and network-based dissection of biological systems

(2010) V. Kaimal et al.   NUCLEIC ACIDS RESEARCH

ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data

(2010) K. Wang et al.   NUCLEIC ACIDS RESEARCH

Regulation and Function of NF-κB Transcription Factors in the Immune System

(2009) Sivakumar Vallabhapurapu et al.   Annual Review of Immunology

ToppGene Suite for gene list enrichment analysis and candidate gene prioritization

(2009) J. Chen et al.   NUCLEIC ACIDS RESEARCH