A neurodevelopmental epigenetic programme mediated by SMARCD3–DAB1–Reelin signalling is hijacked to promote medulloblastoma metastasis

Preclinical efficacy of ribavirin in SHH and group 3 medulloblastoma

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Transcription factor chromatin profiling genome-wide using uliCUT&RUN in single cells and individual blastocysts

(2021) Benjamin J. Patty et al.   Nature Protocols

Spatial and cell type transcriptional landscape of human cerebellar development

(2021) Kimberly A. Aldinger et al.   NATURE NEUROSCIENCE

Visualizing and interpreting cancer genomics data via the Xena platform

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Molecular Heterogeneity and Cellular Diversity: Implications for Precision Treatment in Medulloblastoma

(2020) Han Zou et al.   Cancers

The chromatin remodeling enzyme Chd4 regulates genome architecture in the mouse brain

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Inhibition of enhancer of zest homologue 2 is a potential therapeutic target for high-MYC medulloblastoma

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Emerging connections between cerebellar development, behaviour and complex brain disorders

(2019) Aaron Sathyanesan et al.   NATURE REVIEWS NEUROSCIENCE

Leptomeningeal dissemination: a sinister pattern of medulloblastoma growth

(2019) Daniel W. Fults et al.   Journal of Neurosurgery-Pediatrics

Batch-normalization of cerebellar and medulloblastoma gene expression datasets utilizing empirically defined negative control genes

(2019) Holger Weishaupt et al.   BIOINFORMATICS

Childhood cerebellar tumours mirror conserved fetal transcriptional programs

(2019) Maria C. Vladoiu et al.   NATURE

A phase 1 and randomized, placebo‐controlled phase 2 trial of bevacizumab plus dasatinib in patients with recurrent glioblastoma: Alliance/North Central Cancer Treatment Group N0872

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Resolving medulloblastoma cellular architecture by single-cell genomics

(2019) Volker Hovestadt et al.   NATURE

EZH2 targeting reduces medulloblastoma growth through epigenetic reactivation of the BAI1/p53 tumor suppressor pathway

(2019) Hanwen Zhang et al.   ONCOGENE

Phase 1 trial, pharmacokinetics, and pharmacodynamics of dasatinib combined with crizotinib in children with recurrent or progressive high-grade and diffuse intrinsic pontine glioma

(2018) Alberto Broniscer et al.   PEDIATRIC BLOOD & CANCER

Proteomics, Post-translational Modifications, and Integrative Analyses Reveal Molecular Heterogeneity within Medulloblastoma Subgroups

(2018) Tenley C. Archer et al.   CANCER CELL

A Single-Cell Transcriptional Atlas of the Developing Murine Cerebellum

(2018) Robert A. Carter et al.   CURRENT BIOLOGY

Cicero Predicts cis-Regulatory DNA Interactions from Single-Cell Chromatin Accessibility Data

(2018) Hannah A. Pliner et al.   MOLECULAR CELL

Granule neuron precursor cell proliferation is regulated by NFIX and intersectin 1 during postnatal cerebellar development

(2018) James Fraser et al.   Brain Structure & Function

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Neuronal Migration During Development of the Cerebellum

(2018) Maryam Rahimi-Balaei et al.   Frontiers in Cellular Neuroscience

The whole-genome landscape of medulloblastoma subtypes

(2017) Paul A. Northcott et al.   NATURE

OTX2 Activity at Distal Regulatory Elements Shapes the Chromatin Landscape of Group 3 Medulloblastoma

(2017) Gaylor Boulay et al.   Cancer Discovery

Inactivation of Ezh2 Upregulates Gfi1 and Drives Aggressive Myc-Driven Group 3 Medulloblastoma

(2017) BaoHan T. Vo et al.   Cell Reports

An efficient targeted nuclease strategy for high-resolution mapping of DNA binding sites

(2017) Peter J Skene et al.   eLife

Cardiac-enriched BAF chromatin-remodeling complex subunit Baf60c regulates gene expression programs essential for heart development and function

(2017) Xin Sun et al.   Biology Open

The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary

(2016) David N. Louis et al.   ACTA NEUROPATHOLOGICA

Epigenetic Activation of WNT5A Drives Glioblastoma Stem Cell Differentiation and Invasive Growth

(2016) Baoli Hu et al.   CELL

DiSCoVERing Innovative Therapies for Rare Tumors: Combining Genetically Accurate Disease Models with In Silico Analysis to Identify Novel Therapeutic Targets

(2016) A. R. Hanaford et al.   CLINICAL CANCER RESEARCH

In vitro models of medulloblastoma: Choosing the right tool for the job

(2016) Delyan P. Ivanov et al.   JOURNAL OF BIOTECHNOLOGY

Active medulloblastoma enhancers reveal subgroup-specific cellular origins

(2016) Charles Y. Lin et al.   NATURE

Integrative Analysis Reveals the Transcriptional Collaboration between EZH2 and E2F1 in the Regulation of Cancer-Related Gene Expression

(2015) H. Xu et al.   MOLECULAR CANCER RESEARCH

EpiFactors: a comprehensive database of human epigenetic factors and complexes

(2015) Yulia A. Medvedeva et al.   Database-The Journal of Biological Databases and Curation

Development of the cerebellum: simple steps to make a 'little brain'

(2014) T. Butts et al.   DEVELOPMENT

NFIB-Mediated Repression of the Epigenetic Factor Ezh2 Regulates Cortical Development

(2014) M. Piper et al.   JOURNAL OF NEUROSCIENCE

Recurrence patterns across medulloblastoma subgroups: an integrated clinical and molecular analysis

(2013) Vijay Ramaswamy et al.   LANCET ONCOLOGY

SWI/SNF Chromatin-Remodeling Factor Smarcd3/Baf60c Controls Epithelial-Mesenchymal Transition by Inducing Wnt5a Signaling

(2013) N. V. Jordan et al.   MOLECULAR AND CELLULAR BIOLOGY

Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position

(2013) Jason D Buenrostro et al.   NATURE METHODS

EZH2-Regulated DAB2IP Is a Medulloblastoma Tumor Suppressor and a Positive Marker for Survival

(2012) M. Smits et al.   CLINICAL CANCER RESEARCH

Targeting the enhancer of zeste homologue 2 in medulloblastoma

(2012) Irina Alimova et al.   INTERNATIONAL JOURNAL OF CANCER

Phase 1 trial of dasatinib plus erlotinib in adults with recurrent malignant glioma

(2012) David A. Reardon et al.   JOURNAL OF NEURO-ONCOLOGY

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

EZH2 Oncogenic Activity in Castration-Resistant Prostate Cancer Cells Is Polycomb-Independent

(2012) K. Xu et al.   SCIENCE

Development of the cerebellum: from gene expression patterns to circuit maps

(2012) Joshua J. White et al.   Wiley Interdisciplinary Reviews-Developmental Biology

Molecular subgroups of medulloblastoma: the current consensus

(2011) Michael D. Taylor et al.   ACTA NEUROPATHOLOGICA

Pediatric Phase I Trial and Pharmacokinetic Study of Dasatinib: A Report From the Children's Oncology Group Phase I Consortium

(2011) Richard Aplenc et al.   JOURNAL OF CLINICAL ONCOLOGY

Context-Specific Regulation of NF-κB Target Gene Expression by EZH2 in Breast Cancers

(2011) Shuet Theng Lee et al.   MOLECULAR CELL

Most Random Gene Expression Signatures Are Significantly Associated with Breast Cancer Outcome

(2011) David Venet et al.   PLoS Computational Biology

Retrospective study of dasatinib for recurrent glioblastoma after bevacizumab failure

(2010) C. Lu-Emerson et al.   JOURNAL OF NEURO-ONCOLOGY

Migration, early axonogenesis, and Reelin-dependent layer-forming behavior of early/posterior-born Purkinje cells in the developing mouse lateral cerebellum

(2010) Takaki Miyata et al.   Neural Development