Creatine kinase B suppresses ferroptosis by phosphorylating GPX4 through a moonlighting function

A targetable CoQ-FSP1 axis drives ferroptosis- and radiation-resistance in KEAP1 inactive lung cancers

(2022) Pranavi Koppula et al.   Nature Communications

Aerobic glycolysis promotes tumor immune evasion by hexokinase2-mediated phosphorylation of IκBα

(2022) Dong Guo et al.   Cell Metabolism

The Evolving Landscape of Noncanonical Functions of Metabolic Enzymes in Cancer and Other Pathologies

(2021) Daqian Xu et al.   Cell Metabolism

Ferroptosis: mechanisms, biology and role in disease

(2021) Xuejun Jiang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Creatine kinase B controls futile creatine cycling in thermogenic fat

(2021) Janane F. Rahbani et al.   NATURE

Inositol hexakisphosphate kinase-2 determines cellular energy dynamics by regulating creatine kinase-B

(2021) Latika Nagpal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation

(2021) Yilei Zhang et al.   Nature Communications

DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer

(2021) Chao Mao et al.   NATURE

Fructose and fructose kinase in cancer and other pathologies

(2021) Hongfei Jiang et al.   Journal of Genetics and Genomics

Choline kinase alpha 2 acts as a protein kinase to promote lipolysis of lipid droplets

(2021) Rui Liu et al.   MOLECULAR CELL

Redox Homeostasis and Metabolism in Cancer: A Complex Mechanism and Potential Targeted Therapeutics

(2020) Alia Ghoneum et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis

(2020) Daqian Xu et al.   NATURE

Creatine metabolism: energy homeostasis, immunity and cancer biology

(2020) Lawrence Kazak et al.   Nature Reviews Endocrinology

β-Catenin induces transcriptional expression of PD-L1 to promote glioblastoma immune evasion

(2020) Linyong Du et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A newly discovered role of metabolic enzyme PCK1 as a protein kinase to promote cancer lipogenesis

(2020) Hongfei Jiang et al.   Cancer Communications

Chaperone-mediated autophagy is involved in the execution of ferroptosis

(2019) Zheming Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The protein kinase activity of fructokinase A specifies the antioxidant responses of tumor cells by phosphorylating p62

(2019) Daqian Xu et al.   Science Advances

Intercellular interaction dictates cancer cell ferroptosis via NF2–YAP signalling

(2019) Jiao Wu et al.   NATURE

A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis

(2019) Yilong Zou et al.   Nature Communications

PTEN Suppresses Glycolysis by Dephosphorylating and Inhibiting Autophosphorylated PGK1

(2019) Xu Qian et al.   MOLECULAR CELL

KDM3A Senses Oxygen Availability to Regulate PGC-1α-Mediated Mitochondrial Biogenesis

(2019) Xu Qian et al.   MOLECULAR CELL

Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis

(2018) Irina Ingold et al.   CELL

EGFR-Phosphorylated Platelet Isoform of Phosphofructokinase 1 Promotes PI3K Activation

(2018) Jong-Ho Lee et al.   MOLECULAR CELL

Regulation of chromatin and gene expression by metabolic enzymes and metabolites

(2018) Xinjian Li et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Metabolic Kinases Moonlighting as Protein Kinases

(2018) Zhimin Lu et al.   TRENDS IN BIOCHEMICAL SCIENCES

Soluble Oligomers of Amyloid-β Cause Changes in Redox State, DNA Methylation, and Gene Transcription by Inhibiting EAAT3 Mediated Cysteine Uptake

(2018) Nathaniel Hodgson et al.   JOURNAL OF ALZHEIMERS DISEASE

Metabolic enzyme PFKFB4 activates transcriptional coactivator SRC-3 to drive breast cancer

(2018) Subhamoy Dasgupta et al.   NATURE

The Nrf2/GCH1/BH4 Axis Ameliorates Radiation-Induced Skin Injury by Modulating the ROS Cascade

(2017) Jiao Xue et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy

(2017) Xinjian Li et al.   MOLECULAR CELL

Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition

(2017) Matthew J. Hangauer et al.   NATURE

PGK1 is a new member of the protein kinome

(2016) Xinjian Li et al.   CELL CYCLE

Fructokinase A acts as a protein kinase to promote nucleotide synthesis

(2016) Xinjian Li et al.   CELL CYCLE

PAQR3 controls autophagy by integrating AMPK signaling to enhance ATG14L-associated PI3K activity

(2016) D.-Q. Xu et al.   EMBO JOURNAL

Insulin-like growth factor 1 specifically up-regulates expression of modifier subunit of glutamate-cysteine ligase and enhances glutathione synthesis in SH-SY5Y cells

(2016) Shuhei Takahashi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Mitochondria-Translocated PGK1 Functions as a Protein Kinase to Coordinate Glycolysis and the TCA Cycle in Tumorigenesis

(2016) Xinjian Li et al.   MOLECULAR CELL

A splicing switch from ketohexokinase-C to ketohexokinase-A drives hepatocellular carcinoma formation

(2016) Xinjian Li et al.   NATURE CELL BIOLOGY

Glutathione peroxidase 4 prevents necroptosis in mouse erythroid precursors

(2015) O. Canli et al.   BLOOD

A Creatine-Driven Substrate Cycle Enhances Energy Expenditure and Thermogenesis in Beige Fat

(2015) Lawrence Kazak et al.   CELL

Extracellular Metabolic Energetics Can Promote Cancer Progression

(2015) Jia Min Loo et al.   CELL

PAQR3 modulates cholesterol homeostasis by anchoring Scap/SREBP complex to the Golgi apparatus

(2015) Daqian Xu et al.   Nature Communications

IGF-I Regulates Redox Status in Breast Cancer Cells by Activating the Amino Acid Transport Molecule xC−

(2014) Yuzhe Yang et al.   CANCER RESEARCH

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

(2014) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Redox biology of the intestine

(2011) Magdalena L. Circu et al.   FREE RADICAL RESEARCH

Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

(2011) Weiwei Yang et al.   NATURE

Depletion of Selenoprotein GPx4 in Spermatocytes Causes Male Infertility in Mice

(2009) Hirotaka Imai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reactivation of the insulin-like growth factor-II signaling pathway in human hepatocellular carcinoma

(2008) Kai Breuhahn   WORLD JOURNAL OF GASTROENTEROLOGY