Review
Neurosciences
Kyoung-Doo Hwang, Sang Jeong Kim, Yong-Seok Lee
Summary: The cerebellum plays a critical role in modulating fear memory network and prediction, with involvement at the cellular and synaptic levels. Understanding the contributions of distinct cerebellar structures to fear learning and memory may lead to more effective treatment strategies for fear-related affective disorders.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Ehsan Sedaghat-Nejad, Jay S. Pi, Paul Hage, Mohammad Amin Fakharian, Reza Shadmehr
Summary: The ability of the brain to control movement accurately relies on the cerebellum. Recent research has found that cerebellar P cells transmit information by synchronizing their spikes and utilizing disinhibition to convey important signals for movement control.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Liansheng Chang, Shahid Hussain Soomro, Hongfeng Zhang, Hui Fu
Summary: Ankfy1 protein plays a critical role in the development and maintenance of Purkinje cells in the cerebellum. Its absence leads to loss of most Purkinje cells in the cerebellum, resulting in impaired motor function.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Pharmacology & Pharmacy
Shu-Tao Xie, Wen-Chu Fan, Xian-Sen Zhao, Xiao-Yang Ma, Ze-Lin Li, Yan-Ran Zhao, Fa Yang, Ying Shi, Hui Rong, Zhi-San Cui, Jun-Yi Chen, Hong-Zhao Li, Chao Yan, Qipeng Zhang, Jian-Jun Wang, Xiao-Yang Zhang, Xiao-Ping Gu, Zheng-Liang Ma, Jing-Ning Zhu
Summary: Specific medications for cerebellar ataxias are still lacking, but the activation of cerebellar microglia has been found to be common in ataxic patients and rodent models. This study provides direct evidence that activating cerebellar microglia induces ataxia symptoms and worsens motor deficits in a mouse model of cerebellar ataxia. The activation of microglia leads to the hyperexcitation of Purkinje cells which triggers ataxia, and inhibiting microglia activation can alleviate motor deficits in mice.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Biology
Sol Pose-Mendez, Paul Schramm, Barbara Winter, Jochen C. Meier, Konstantinos Ampatzis, Reinhard W. Koester
Summary: Zebrafish are capable of regenerating neurons in the central nervous system, including Purkinje cells. The study demonstrates that when the Purkinje cells are ablated, they can quickly recover, regain their electrophysiological properties, and restore cerebellum-controlled behavior. Furthermore, the study also shows that Purkinje cell progenitors are present in both larvae and adults, and adult zebrafish are able to regenerate different types of Purkinje cells to restore behavioral impairments.
Article
Neurosciences
Nicola Loi, Francesca Ginatempo, Cristina Doppiu, Franca Deriu
Summary: This study found that passively viewing emotional facial expressions affects cerebellar learning processes, with sad faces reducing excitability of the cerebellar circuit and both happy and sad faces shortening the extinction phase. The study provides evidence of cerebellar involvement in processing emotional facial expressions.
Article
Mathematical & Computational Biology
Matthew Ricci, Junkyung Kim, Fredrik Johansson
Summary: The cerebellar Purkinje cell controls eyeblinks and can learn, remember, and reproduce the timing of stimuli in a classical conditioning paradigm. Previous models suggest that the perception of time is represented in upstream networks, but direct stimulation of the Purkinje cell during conditioning still results in a well-timed response. Furthermore, experimental findings indicate that the acquired Purkinje cell response is insensitive to variations in the temporal structure of probe stimulation, motivating the development of alternative models.
FRONTIERS IN COMPUTATIONAL NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Martijn Schonewille, Allison E. Girasole, Philippe Rostaing, Caroline Mailhes-Hamon, Annick Ayon, Alexandra B. Nelson, Antoine Triller, Mariano Casado, Chris De Zeeuw, Guy Bouvier
Summary: The study reveals that NMDARs are present and functional in presynaptic terminals of adult rodents, playing a crucial role in bidirectional synaptic plasticity and cerebellar motor learning.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Biochemistry & Molecular Biology
Adolfo Toledano-Diaz, Maria Isabel Alvarez, Jose-Julio Rodriguez, Juan Jose Badiola, Marta Monzon, Adolfo Toledano
Summary: This review discusses the most important neuropathological changes found in the cerebella of sheep affected by classical natural scrapie, emphasizing on neuron abnormalities, neurogliosis, tissue vacuolization, and abnormal PrP deposits. Various aspects related to disease presentation, progression, neuroglial responses, and controversial points in scrapie neuropathology are explored.
Article
Clinical Neurology
Ester Perez-Martin, Rodrigo Munoz-Castaneda, Marie-Jo Moutin, Carmelo A. avila-Zarza, Jose M. Munoz-Castaneda, Carlos Del Pilar, Jose R. Alonso, Annie Andrieux, David Diaz, Eduardo Weruaga
Summary: The study found that OEA can prevent morphological changes in Purkinje cells and reduce cell death in mice before neurodegeneration occurs, leading to improvements in motor, cognitive, and social functions.
Article
Neurosciences
Rui Zheng, Fang-Xiao Xu, Lin Zhou, Junyu Xu, Ying Shen, Ke Hao, Xin-Tai Wang, Junjie Deng
Summary: KIF2C is a protein that is believed to play a role in tumor progression, metastasis, neurodegenerative diseases, and psychiatric disorders. Our study shows that KIF2C is widely distributed in various regions of the brain and is localized in synaptic spines. It regulates microtubule dynamic properties, AMPA receptor transport, and cognitive behavior in mice.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Review
Neurosciences
Meike E. van der Heijden, Roy V. Sillitoe
Summary: Cerebellar development is a complex process involving interactions between inhibitory Purkinje cells and excitatory granule cells, with Purkinje cells considered as master regulators of the process. The connectivity and function of Purkinje cells are influenced by cues provided by granule cells, which help shape the firing properties of Purkinje cells. This dynamic interplay between different cell types is essential for the establishment of mature cerebellar circuits.
Article
Neurosciences
Ya-Yun Wang, Hui Liu, Shu-Jiao Li, Ban Feng, Yun-Qiang Huang, Shui-Bing Liu, Yan-Ling Yang
Summary: This study is the first to report the close relationship between UCP4 deletion and impairment of cerebellar Purkinje cells (PCs), highlighting the importance of UCP4 in maintaining mitochondrial function homeostasis in bradykinesia. UCP4 may be a potential therapeutic target for cerebellar-related movement disorders.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yeming Yang, Guo Huang, Xiaoyan Jiang, Xiao Li, Kuanxiang Sun, Yi Shi, Zhenglin Yang, Xianjun Zhu
Summary: The study reveals the critical role of WTAP-mediated m(6)A modification in cerebellar Purkinje cells, which regulates the degradation of multiple cell synapses and affects cerebellar development and function. Loss of WTAP leads to early-onset ataxia, cerebellar atrophy, and severe neuronal injuries.
JOURNAL OF GENETICS AND GENOMICS
(2022)
Article
Neurosciences
Ri Wang, Chao Liu, Wenyan Guo, Lixuan Wang, Siruan Chen, Jiaojiao Zhao, Xia Qin, Wanjun Bai, Zuxiao Yang, Dezhi Kong, Zhanfeng Jia, Shufeng Liu, Wei Zhang
Summary: FRRS1L protein, as an auxiliary regulatory protein for AMPAR, is highly expressed in the cerebellum and other brain regions associated with motor function control. Deletion of FRRS1L leads to impaired motor coordination and cerebellar ataxia in mice, characterized by hyperactivity, reduced muscle strength, impaired coordination, and ataxia. Furthermore, FRRS1L deletion also affects the morphology and function of Purkinje cells in the cerebellum.
BRAIN RESEARCH BULLETIN
(2022)
Article
Multidisciplinary Sciences
Anders Rasmussen, Riccardo Zucca, Fredrik Johansson, Dan-Anders Jirenhed, Germund Hesslow
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2015)
Article
Multidisciplinary Sciences
Dan-Anders Jirenhed, Anders Rasmussen, Fredrik Johansson, Germund Hesslow
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Multidisciplinary Sciences
Anders Rasmussen, Dan-Anders Jirenhed
SCIENTIFIC REPORTS
(2017)
Article
Neurosciences
Anders Rasmussen, Dan-Anders Jirenhed, Germund Hesslow
Article
Neurosciences
Dan-Anders Jirenhed, Germund Hesslow
Article
Neurosciences
A. Rasmussen, R. Zucca, D-A. Jirenhed, F. Johansson, C. Ortenblad, P. Svensson, G. Hesslow
Article
Neurosciences
Par Svensson, Dan-Anders Jirenhed, Fredrik Bengtsson, Germund Hesslow
JOURNAL OF NEUROPHYSIOLOGY
(2010)
Article
Neurosciences
Dan-Anders Jirenhed, Germund Hesslow
JOURNAL OF NEUROSCIENCE
(2011)
Article
Neurosciences
Anders Rasmussen, Dan-Anders Jirenhed, Riccardo Zucca, Fredrik Johansson, Par Svensson, Germund Hesslow
JOURNAL OF NEUROSCIENCE
(2013)
Article
Neurosciences
Daniel Z. Wetmore, Dan-Anders Jirenhed, Anders Rasmussen, Fredrik Johansson, Mark J. Schnitzer, Germund Hesslow
JOURNAL OF NEUROSCIENCE
(2014)
Article
Computer Science, Artificial Intelligence
Germund Hesslow, Dan-Anders Jirenhed, Anders Rasmussen, Fredrik Johansson
Article
Multidisciplinary Sciences
Fredrik Johansson, Dan-Anders Jirenhed, Anders Rasmussen, Riccardo Zucca, Germund Hesslow
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2014)
Article
Neurosciences
Anders Rasmussen, Dan-Anders Jirenhed, Daniel Z. Wetmore, Germund Hesslow
FRONTIERS IN NEURAL CIRCUITS
(2014)
Article
Neurosciences
Dan-Anders Jirenhed, Fredrik Bengtsson, Henrik Jorntell
FRONTIERS IN SYSTEMS NEUROSCIENCE
(2013)