Efficacy and Safety of Eliapixant in Refractory Chronic Cough: The Randomized, Placebo-Controlled Phase 2b PAGANINI Study

First‐in‐human study of eliapixant (BAY 1817080), a highly selective P2X3 receptor antagonist: Tolerability, safety and pharmacokinetics

(2022) Stefan Klein et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Safety, Pharmacodynamics, and Pharmacokinetics of P2X3 Receptor Antagonist Eliapixant (BAY 1817080) in Healthy Subjects: Double-Blind Randomized Study

(2022) Christian Friedrich et al.   CLINICAL PHARMACOKINETICS

Efficacy and safety of gefapixant, a P2X3 receptor antagonist, in refractory chronic cough and unexplained chronic cough (COUGH-1 and COUGH-2): results from two double-blind, randomised, parallel-group, placebo-controlled, phase 3 trials

(2022) Lorcan P McGarvey et al.   LANCET

A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Phase 2b Trial of P2X3 Receptor Antagonist Sivopixant for Refractory or Unexplained Chronic Cough

(2022) Lorcan McGarvey et al.   LUNG

Eliapixant (BAY 1817080), a P2X3 receptor antagonist, in refractory chronic cough: a randomised, placebo-controlled, crossover phase 2a study

(2021) Alyn Morice et al.   EUROPEAN RESPIRATORY JOURNAL

Performance of a digital signal processing algorithm for the accurate quantification of cough frequency

(2021) Jaclyn A. Smith et al.   EUROPEAN RESPIRATORY JOURNAL

Randomised trial of the P2X3 receptor antagonist sivopixant for refractory chronic cough

(2021) Akio Niimi et al.   EUROPEAN RESPIRATORY JOURNAL

Chronic cough: new insights and future prospects

(2021) Alyn Morice et al.   European Respiratory Review

Gefapixant, a P2X3 receptor antagonist, for the treatment of refractory or unexplained chronic cough: a randomised, double-blind, controlled, parallel-group, phase 2b trial

(2020) Jaclyn A Smith et al.   Lancet Respiratory Medicine

Mechanisms and Rationale for Targeted Therapies in Refractory and Unexplained Chronic Cough

(2020) Stuart Mazzone et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

BLU-5937: A selective P2X3 antagonist with potent anti-tussive effect and no taste alteration

(2019) Denis Garceau et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

ERS guidelines on the diagnosis and treatment of chronic cough in adults and children

(2019) Alyn H. Morice et al.   EUROPEAN RESPIRATORY JOURNAL

The global epidemiology of chronic cough in adults: a systematic review and meta-analysis

(2015) Woo-Jung Song et al.   EUROPEAN RESPIRATORY JOURNAL

A worldwide survey of chronic cough: a manifestation of enhanced somatosensory response

(2014) A. H. Morice et al.   EUROPEAN RESPIRATORY JOURNAL

Quality of life in patients with chronic cough

(2010) Emma C. Young et al.   Therapeutic Advances in Respiratory Disease

P2X2 receptors differentiate placodal vs. neural crest C-fiber phenotypes innervating guinea pig lungs and esophagus

(2008) Kevin Kwong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY