Chronic cough: new insights and future prospects

Prevalence, progression and impact of chronic cough on employment in Northern Europe

(2021) Henrik Johansson et al.   EUROPEAN RESPIRATORY JOURNAL

Cough Triggers and Symptoms Among Patients with Refractory or Unexplained Chronic Cough in Two Phase 3 Trials of the P2X3 Receptor Antagonist Gefapixant (COUGH-1 and COUGH-2)

(2021) Alyn Morice et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Eliapixant (BAY 1817080), a P2X3 receptor antagonist, in refractory chronic cough: a randomised, placebo-controlled, crossover phase 2a study

(2021) Alyn Morice et al.   EUROPEAN RESPIRATORY JOURNAL

Characterization of Patients With Refractory or Unexplained Chronic Cough Participating in a Phase 2 Clinical Trial of the P2X3-Receptor Antagonist Gefapixant

(2021) Alyn H. Morice et al.   LUNG

On Chronic Cough Diagnosis, Classification, and Treatment

(2021) Alyn Hugh Morice   LUNG

Direct costs of illness of patients with chronic cough in rural Malawi—Experiences from Dowa and Ntchisi districts

(2020) Junious M. Sichali et al.   PLoS One

Gefapixant, a P2X3 receptor antagonist, for the treatment of refractory or unexplained chronic cough: a randomised, double-blind, controlled, parallel-group, phase 2b trial

(2020) Jaclyn A Smith et al.   Lancet Respiratory Medicine

Exploring the clinical relevance of cough hypersensitivity syndrome

(2020) Woo-Jung Song et al.   Expert Review of Respiratory Medicine

Cough persistence in adults with chronic cough: A 4-year retrospective cohort study

(2020) Sung-Yoon Kang et al.   ALLERGOLOGY INTERNATIONAL

Mechanisms and Rationale for Targeted Therapies in Refractory and Unexplained Chronic Cough

(2020) Stuart Mazzone et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

P2X3-Receptor Antagonists as Potential Antitussives: Summary of Current Clinical Trials in Chronic Cough

(2020) Peter V. Dicpinigaitis et al.   LUNG

Airway Sensory Nerve Density is Increased in Chronic Cough

(2020) Clare O. Shapiro et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

What is the Role of Over 100 Excipients in Over the Counter (OTC) Cough Medicines?

(2020) Ronald Eccles   LUNG

Peripheral and central mechanisms of cough hypersensitivity

(2020) Nabita Singh et al.   Journal of Thoracic Disease

The Effectiveness of Nortriptyline and Tolerability of Side Effects in Neurogenic Cough Patients

(2020) Sungjin A. Song et al.   ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY

Update on the clinical development of gefapixant, a P2X3 receptor antagonist for the treatment of refractory chronic cough

(2019) David Muccino et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Defining Minimal Clinically Important Differences (MCID) on the Leicester Cough Questionnaire (LCQ): Analyses of a Phase 2 Randomized Controlled Trial in Chronic Cough

(2019) Surinder Birring et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The Effect of Gefapixant, a P2X3 antagonist, on Cough Reflex Sensitivity: A randomised placebo-controlled study

(2019) Alyn H. Morice et al.   EUROPEAN RESPIRATORY JOURNAL

Chronic cough: a disorder of response inhibition?

(2019) Stuart B. Mazzone   EUROPEAN RESPIRATORY JOURNAL

New understanding in the treatment of cough (NEUROCOUGH) ERS Clinical Research Collaboration: improving care and treatment for patients with cough

(2019) Lorcan McGarvey et al.   EUROPEAN RESPIRATORY JOURNAL

BLU-5937: A selective P2X3 antagonist with potent anti-tussive effect and no taste alteration

(2019) Denis Garceau et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Cough: New Pharmacology

(2019) Jaclyn A. Smith et al.   Journal of Allergy and Clinical Immunology-In Practice

The Neurokinin-1 Receptor Antagonist Orvepitant is a Novel Antitussive Therapy for Chronic Refractory Cough

(2019) Jaclyn Smith et al.   CHEST

Cough presentation in primary care and the identification of chronic cough: a need for diagnostic clarity?

(2019) Sarah E Holden et al.   CURRENT MEDICAL RESEARCH AND OPINION

ERS guidelines on the diagnosis and treatment of chronic cough in adults and children

(2019) Alyn H. Morice et al.   EUROPEAN RESPIRATORY JOURNAL

Characteristics of Chinese chronic cough patients

(2019) Li Long et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

ATP cough challenge

(2019) Alyn Morice   PULMONARY PHARMACOLOGY & THERAPEUTICS

The Powerful Placebo Effect in Cough: Relevance to Treatment and Clinical Trials

(2019) Ron Eccles   LUNG

An update and systematic review on drug therapies for the treatment of refractory chronic cough

(2018) Nicole M. Ryan et al.   EXPERT OPINION ON PHARMACOTHERAPY

Oral corticosteroid exposure and adverse effects in asthmatic patients

(2018) Patrick W. Sullivan et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The role of high resolution oesophageal manometry in occult respiratory symptoms

(2018) Jennifer M. Burke et al.   RESPIRATORY MEDICINE

Defining the risk factors for acute, subacute and chronic cough: a cross-sectional study in a Finnish adult employee population

(2018) Anne M Lätti et al.   BMJ Open

The heterogeneity of chronic cough: a case for endotypes of cough hypersensitivity

(2018) Stuart B Mazzone et al.   Lancet Respiratory Medicine

Clinical Practice Guidelines for Diagnosis and Management of Cough—Chinese Thoracic Society (CTS) Asthma Consortium

(2018) Kefang Lai et al.   Journal of Thoracic Disease

Point prevalence and epidemiological characteristics of chronic cough in the general adult population

(2017) Min-Gyu Kang et al.   MEDICINE

TRPA1 receptors in chronic cough

(2017) Alyn H Morice   PULMONARY PHARMACOLOGY & THERAPEUTICS

Cough and airway disease: The role of ion channels

(2017) Sara J. Bonvini et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Cough Hypersensitivity Syndrome: A Few More Steps Forward

(2017) Woo-Jung Song et al.   Allergy Asthma & Immunology Research

Korean version of the Cough Symptom Score: clinical utility and validity for chronic cough

(2017) Jae-Woo Kwon et al.   KOREAN JOURNAL OF INTERNAL MEDICINE

P2X3 receptor involvement in endometriosis pain via ERK signaling pathway

(2017) Shaojie Ding et al.   PLoS One

Treatment of Unexplained Chronic Cough

(2016) Peter Gibson et al.   CHEST

Pregabalin and Speech Pathology Combination Therapy for Refractory Chronic Cough

(2016) Anne E. Vertigan et al.   CHEST

Treatable traits: toward precision medicine of chronic airway diseases

(2016) Alvar Agusti et al.   EUROPEAN RESPIRATORY JOURNAL

Transient receptor potential cation channel, subfamily V, member 4 and airway sensory afferent activation: Role of adenosine triphosphate

(2016) Sara J. Bonvini et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Reliability and Validity of the Swedish Version of the Hull Airway Reflux Questionnaire (HARQ-S)

(2016) Ewa-Lena Johansson et al.   LUNG

Vagal Afferent Innervation of the Airways in Health and Disease

(2016) Stuart B. Mazzone et al.   PHYSIOLOGICAL REVIEWS

Tools for Assessing Outcomes in Studies of Chronic Cough

(2015) Louis-Philippe Boulet et al.   CHEST

Cough hypersensitivity syndrome: clinical measurement is the key to progress

(2015) Alyn H. Morice et al.   EUROPEAN RESPIRATORY JOURNAL

The global epidemiology of chronic cough in adults: a systematic review and meta-analysis

(2015) Woo-Jung Song et al.   EUROPEAN RESPIRATORY JOURNAL

P2X3 receptor antagonist (AF-219) in refractory chronic cough: a randomised, double-blind, placebo-controlled phase 2 study

(2015) Rayid Abdulqawi et al.   LANCET

The Impact of Chronic Cough: A Cross-Sectional European Survey

(2015) Sarah A. F. Chamberlain et al.   LUNG

Reliability and Validity of a Korean Version of the Leicester Cough Questionnaire

(2015) Jae-Woo Kwon et al.   Allergy Asthma & Immunology Research

Management of chronic refractory cough

(2015) Peter G Gibson et al.   BMJ-British Medical Journal

Management of chronic refractory cough

(2015) Peter G Gibson et al.   BMJ-British Medical Journal

Validation of the Mandarin Chinese version of the Leicester Cough Questionnaire in bronchiectasis

(2015) Y-H. Gao et al.   INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE

Overview of the Management of Cough

(2014) Richard S. Irwin et al.   CHEST

Anatomy and Neurophysiology of Cough

(2014) Brendan J. Canning et al.   CHEST

A worldwide survey of chronic cough: a manifestation of enhanced somatosensory response

(2014) A. H. Morice et al.   EUROPEAN RESPIRATORY JOURNAL

Expert opinion on the cough hypersensitivity syndrome in respiratory medicine

(2014) A. H. Morice et al.   EUROPEAN RESPIRATORY JOURNAL

Transient receptor potential vanilloid 1 (TRPV1) antagonism in patients with refractory chronic cough: A double-blind randomized controlled trial

(2014) Saifudin Khalid et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Montelukast-Induced Adverse Drug Reactions: A Review of Case Reports in the Literature

(2014) Gioacchino Calapai et al.   PHARMACOLOGY

Chronic cough: from a complex dysfunction of the neurological circuit to the production of persistent cough

(2014) Adalberto Pacheco   THORAX

Brain Activity Associated with Placebo Suppression of the Urge-to-Cough in Humans

(2013) Jennifer Leech et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Assessing regression to the mean effects in health care initiatives

(2013) Ariel Linden   BMC Medical Research Methodology

Sex differences in pain: a brief review of clinical and experimental findings

(2013) E.J. Bartley et al.   BRITISH JOURNAL OF ANAESTHESIA

Purinergic signalling: from discovery to current developments

(2013) Geoffrey Burnstock   EXPERIMENTAL PHYSIOLOGY

Cough in the Elderly Population: Relationships with Multiple Comorbidity

(2013) Woo-Jung Song et al.   PLoS One

Cough suppression therapy: Does it work?

(2013) Sarah Chamberlain et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Cough syncope

(2013) Peter V. Dicpinigaitis et al.   RESPIRATORY MEDICINE

Azithromycin and cough-specific health status in patients with chronic obstructive pulmonary disease and chronic cough: a randomised controlled trial

(2013) Farida F Berkhof et al.   RESPIRATORY RESEARCH

Inhaled corticosteroids in COPD and the risk of serious pneumonia

(2013) Samy Suissa et al.   THORAX

Chronic cough as a neuropathic disorder

(2013) Kian Fan Chung et al.   Lancet Respiratory Medicine

Montelukast for postinfectious cough in adults: a double-blind randomised placebo-controlled trial

(2013) Kay Wang et al.   Lancet Respiratory Medicine

Gabapentin for refractory chronic cough: a randomised, double-blind, placebo-controlled trial

(2012) Nicole M Ryan et al.   LANCET

The long term outcome of patients with unexplained chronic cough

(2012) Nadia Yousaf et al.   RESPIRATORY MEDICINE

P159 Validation of the VitaloJAK™ 24 Hour Ambulatory Cough Monitor: Abstract P159 Table 1

(2012) K McGuinness et al.   THORAX

Cough Triggers and Their Pathophysiology in Patients with Prolonged or Chronic Cough

(2012) Hisako Matsumoto et al.   ALLERGOLOGY INTERNATIONAL

Therapeutic potential of purinergic signalling for diseases of the urinary tract

(2011) Geoffrey Burnstock   BJU INTERNATIONAL

Randomised clinical trial: high-dose acid suppression for chronic cough - a double-blind, placebo-controlled study

(2010) N. J. Shaheen et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

A prospective global measure, the Punum Ladder, provides more valid assessments of quality of life than a retrospective transition measure

(2010) Kenneth E. Fletcher et al.   JOURNAL OF CLINICAL EPIDEMIOLOGY

Cough Hypersensitivity Syndrome: A Distinct Clinical Entity

(2010) A. H. Morice et al.   LUNG

Long-term low-dose erythromycin in patients with unexplained chronic cough: a double-blind placebo controlled trial

(2010) N. Yousaf et al.   THORAX

Quality of life in patients with chronic cough

(2010) Emma C. Young et al.   Therapeutic Advances in Respiratory Disease

Measuring cough severity: development and pilot testing of a new seven-item cough severity patient-reported outcome measure

(2010) Margaret Vernon et al.   Therapeutic Advances in Respiratory Disease

Effect of the Management of Patients With Chronic Cough by Pulmonologists and Certified Respiratory Educators on Quality of Life

(2009) Stephen K. Field et al.   CHEST

Nonacid Reflux Episodes Reaching the Pharynx are Important Factors Associated With Cough

(2009) Neil Patterson et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Potential side effects in patients treated with inhaled corticosteroids and long-acting β2-agonists

(2009) J. Korsgaard et al.   RESPIRATORY MEDICINE

P2X2 receptors differentiate placodal vs. neural crest C-fiber phenotypes innervating guinea pig lungs and esophagus

(2008) Kevin Kwong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The Leicester Cough Monitor: preliminary validation of an automated cough detection system in chronic cough

(2008) S. S. Birring et al.   EUROPEAN RESPIRATORY JOURNAL

Impact of Cough Across Different Chronic Respiratory Diseases

(2007) Liam Polley et al.   CHEST