期刊
ADVANCED MATERIALS
卷 28, 期 6, 页码 1159-1175出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201502888
关键词
combinatorial synthesis; lipids; polymers; high-throughput; gene delivery; cell transfection
类别
资金
- Helmholtz Association's Initiative and Networking Fund [VH-NG-621]
- European Research Council [ERC-2013-StG 337077-DropCellArray]
Nanoparticles based on cationic polymers, lipids or lipidoids are of great interest in the field of gene delivery applications. The research on these nanosystems is rapidly growing as they hold promise to treat wide variety of human diseases ranging from viral infections to genetic disorders and cancer. Recently, combinatorial design principles have been adopted for rapid generation of large numbers of chemically diverse polymers and lipids capable of forming multifunctional nanocarriers for the use in gene delivery applications. At the same time, current high-throughput screening systems as well as convenient cell assays and readout techniques allow for fast evaluation of cell transfection efficiencies and toxicities of libraries of novel gene delivery agents. This allows for a rapid evaluation of structure-function relationship as well as identification of novel efficient nanocarriers for cell transfection and gene therapy. Here, the recent contribution of high-throughput synthesis to the development of novel nanocarriers for gene delivery applications is described.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据