GRIM19 ameliorates acute graft-versus-host disease (GVHD) by modulating Th17 and Treg cell balance through down-regulation of STAT3 and NF-AT activation

CD4+ T cell STAT3 phosphorylation precedes acute GVHD, and subsequent Th17 tissue invasion correlates with GVHD severity and therapeutic response

(2015) Brian C. Betts et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Increased Th17/Treg ratio in chronic liver GVHD

(2014) F Malard et al.   BONE MARROW TRANSPLANTATION

Red Ginseng Extract Ameliorates Autoimmune Arthritis via Regulation of STAT3 Pathway, Th17/Treg Balance, and Osteoclastogenesis in Mice and Human

(2014) JooYeon Jhun et al.   MEDIATORS OF INFLAMMATION

EGCG Attenuates Autoimmune Arthritis by Inhibition of STAT3 and HIF-1α with Th17/Treg Control

(2014) Eun-Ji Yang et al.   PLoS One

Inflammation-Induced NFATc1-STAT3 Transcription Complex Promotes Pancreatic Cancer Initiation by KrasG12D

(2014) S. Baumgart et al.   Cancer Discovery

The Expression of Th17-Associated Cytokines in Human Acute Graft-versus-Host Disease

(2013) Yuejun Liu et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

IL-1  and TLR4 Signaling Are Involved in the Aggravated Murine Acute Graft-versus-Host Disease Caused by Delayed Bortezomib Administration

(2013) Y. Liang et al.   JOURNAL OF IMMUNOLOGY

STAT5 polarization promotes iTregs and suppresses human T-cell alloresponses while preserving CTL capacity

(2013) Brian C. Betts et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Monoallelic loss of tumor suppressor GRIM-19 promotes tumorigenesis in mice

(2013) S. Kalakonda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gene Associated With Retinoid-Interferon-Induced Mortality 19 Attenuates Murine Autoimmune Arthritis by Regulation of Th17 and Treg Cells

(2013) Young-Mee Moon et al.   Arthritis & Rheumatology

The Role of Regulatory T Cells in the Biology of Graft Versus Host Disease

(2013) Amy J. Beres et al.   Frontiers in Immunology

STAT3 Transcription Factor Promotes Instability of nTreg Cells and Limits Generation of iTreg Cells during Acute Murine Graft-versus-Host Disease

(2012) Arian Laurence et al.   IMMUNITY

Immunotherapy earns its spot in the ranks of cancer therapy

(2012) Drew Pardoll et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Attenuation of Acute Graft-versus-Host Disease in the Absence of the Transcription Factor ROR t

(2012) L. M. Fulton et al.   JOURNAL OF IMMUNOLOGY

RAGE-Dependent Activation of the Oncoprotein Pim1 Plays a Critical Role in Systemic Vascular Remodeling Processes

(2011) Jolyane Meloche et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Th1 and Th17 join forces for acute GVHD

(2011) T. Teshima   BLOOD

Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation

(2011) M. Di Ianni et al.   BLOOD

Th17/Treg ratio in human graft-versus-host disease

(2010) P. Ratajczak et al.   BLOOD

Interleukin-6 Modulates Graft-versus-Host Responses after Experimental Allogeneic Bone Marrow Transplantation

(2010) I. Tawara et al.   CLINICAL CANCER RESEARCH

Hepatobiliary Complications of Hematopoietic Cell Transplantation, 40 Years On

(2010) George B. McDonald   HEPATOLOGY

Overexpression of GRIM-19 in Cancer Cells Suppresses STAT3-Mediated Signal Transduction and Cancer Growth

(2010) Takashi Okamoto et al.   MOLECULAR CANCER THERAPEUTICS

Lethal graft-versus-host disease in mouse models of T cell receptor gene therapy

(2010) Gavin M Bendle et al.   NATURE MEDICINE

PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors

(2010) M. A. Curran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms Underlying Lineage Commitment and Plasticity of Helper CD4+ T Cells

(2010) J. J. O'Shea et al.   SCIENCE

Acute graft-versus-host disease: from the bench to the bedside

(2009) G. Socie et al.   BLOOD

Th2 Cell Therapy of Established Acute Graft-Versus-Host Disease Requires IL-4 and IL-10 and Is Abrogated by IL-2 or Host-Type Antigen-Presenting Cells

(2008) Jason E. Foley et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

IL-17 contributes to CD4-mediated graft-versus-host disease

(2008) L. W. Kappel et al.   BLOOD