CD4+ T cell STAT3 phosphorylation precedes acute GVHD, and subsequent Th17 tissue invasion correlates with GVHD severity and therapeutic response

Tacrolimus/sirolimus vs tacrolimus/methotrexate as GVHD prophylaxis after matched, related donor allogeneic HCT

(2014) C. Cutler et al.   BLOOD

Activated innate lymphoid cells are associated with a reduced susceptibility to graft-versus-host disease

(2014) J. M. Munneke et al.   BLOOD

Pro-inflammatory human Th17 cells selectively express P-glycoprotein and are refractory to glucocorticoids

(2014) Radha Ramesh et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CX3CR1+mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22

(2014) Randy S. Longman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Nfil3 is crucial for development of innate lymphoid cells and host protection against intestinal pathogens

(2014) Theresa L. Geiger et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Stat3 promotes IL-10 expression in lupus T cells throughtrans-activation and chromatin remodeling

(2014) Christian M. Hedrich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human regulatory T cells against minor histocompatibility antigens: ex vivo expansion for prevention of graft-versus-host disease

(2013) A. Veerapathran et al.   BLOOD

In Vivo Induction of Cutaneous Inflammation Results in the Accumulation of Extracellular Trap-Forming Neutrophils Expressing RORγt and IL-17

(2013) Romy R.M.C Keijsers et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

STAT5 polarization promotes iTregs and suppresses human T-cell alloresponses while preserving CTL capacity

(2013) Brian C. Betts et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Interleukin-17–producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity

(2013) Hye Young Kim et al.   NATURE MEDICINE

A randomized phase II study to evaluate tacrolimus in combination with sirolimus or methotrexate after allogeneic hematopoietic cell transplantation

(2012) J. Pidala et al.   HAEMATOLOGICA

STAT3 Transcription Factor Promotes Instability of nTreg Cells and Limits Generation of iTreg Cells during Acute Murine Graft-versus-Host Disease

(2012) Arian Laurence et al.   IMMUNITY

Upstream Stimulating Factors Regulate the Expression of ROR T in Human Lymphocytes

(2012) M. Ratajewski et al.   JOURNAL OF IMMUNOLOGY

Fyn Promotes Th17 Differentiation by Regulating the Kinetics of ROR t and Foxp3 Expression

(2012) A. Ueda et al.   JOURNAL OF IMMUNOLOGY

Attenuation of Acute Graft-versus-Host Disease in the Absence of the Transcription Factor ROR t

(2012) L. M. Fulton et al.   JOURNAL OF IMMUNOLOGY

AZD1480 Blocks Growth and Tumorigenesis of RET- Activated Thyroid Cancer Cell Lines

(2012) Joana P. Couto et al.   PLoS One

PI3K-Akt-mTORC1-S6K1/2 Axis Controls Th17 Differentiation by Regulating Gfi1 Expression and Nuclear Translocation of RORγ

(2012) Yutaka Kurebayashi et al.   Cell Reports

Prevention of GVHD while sparing GVL effect by targeting Th1 and Th17 transcription factor T-bet and ROR t in mice

(2011) Y. Yu et al.   BLOOD

Anti-IL6-receptor-alpha (tocilizumab) does not inhibit human monocyte-derived dendritic cell maturation or alloreactive T-cell responses

(2011) B. C. Betts et al.   BLOOD

Janus kinase-2 inhibition induces durable tolerance to alloantigen by human dendritic cell-stimulated T cells yet preserves immunity to recall antigen

(2011) B. C. Betts et al.   BLOOD

Ex vivo expansion of human Tregs specific for alloantigens presented directly or indirectly

(2011) A. Veerapathran et al.   BLOOD

Ustekinumab demonstrates activity in glucocorticoid-refractory acute GVHD

(2011) J Pidala et al.   BONE MARROW TRANSPLANTATION

Mast Cells and Neutrophils Release IL-17 through Extracellular Trap Formation in Psoriasis

(2011) A. M. Lin et al.   JOURNAL OF IMMUNOLOGY

Graft-versus-Host Disease Treatment: Predictors of Survival

(2010) John E. Levine et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Blood and Gastric FOXP3+ T Cells Are Not Decreased in Human Gastric Graft-versus-Host Disease

(2010) James D. Lord et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Blockade of interleukin-23 signaling results in targeted protection of the colon and allows for separation of graft-versus-host and graft-versus-leukemia responses

(2010) R. Das et al.   BLOOD

Cutaneous GVHD is associated with the expansion of tissue-localized Th1 and not Th17 cells

(2010) R. Broady et al.   BLOOD

Th17/Treg ratio in human graft-versus-host disease

(2010) P. Ratajczak et al.   BLOOD

Th17 and Regulatory T Cells in Mediating and Restraining Inflammation

(2010) Dan R. Littman et al.   CELL

Cutting Edge: A Critical Functional Role for IL-23 in Psoriasis

(2010) G. Tonel et al.   JOURNAL OF IMMUNOLOGY

Comparison of Ustekinumab and Etanercept for Moderate-to-Severe Psoriasis

(2010) Christopher E.M. Griffiths et al.   NEW ENGLAND JOURNAL OF MEDICINE

T helper17 Cells Are Sufficient But Not Necessary to Induce Acute Graft-Versus-Host Disease

(2009) Cristina Iclozan et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Treatment with rapamycin ameliorates clinical and histological signs of protracted relapsing experimental allergic encephalomyelitis in Dark Agouti rats and induces expansion of peripheral CD4+CD25+Foxp3+ regulatory T cells

(2009) Marco Donia et al.   JOURNAL OF AUTOIMMUNITY

A biomarker panel for acute graft-versus-host disease

(2008) S. Paczesny et al.   BLOOD

IL-17 contributes to CD4-mediated graft-versus-host disease

(2008) L. W. Kappel et al.   BLOOD

The strength of T cell stimulation determines IL-7 responsiveness, secondary expansion, and lineage commitment of primed human CD4+IL-7Rhi T cells

(2007) Laura Lozza et al.   EUROPEAN JOURNAL OF IMMUNOLOGY